3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID
- Product Name
- 3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID
- CAS No.
- 179528-45-1
- Chemical Name
- 3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID
- Synonyms
- CS-2366;PD 150606;PD150606 (PD 150606;PD150606;PD-150606;PD 150606;(Z)-3-(4-iodophenyl)-2-mercaptoacrylic acid;(Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid;3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID;(Z)-3-(4-IODOPHENYL)-2-SULFANYLPROP-2-ENOIC ACID;(2Z)-3-(4-iodophenyl)-2-mercapto-2-Propenoic acid;(2Z)-3-(4-iodophenyl)-2-sulfanylprop-2-enoic acid
- CBNumber
- CB6767143
- Molecular Formula
- C9H7IO2S
- Formula Weight
- 306.12
- MOL File
- Mol file
3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID Property
- Boiling point:
- 410.4±45.0 °C(Predicted)
- Density
- 1.901±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: >20mg/mL
- form
- powder
- pka
- 2.98±0.10(Predicted)
- color
- yellowish
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety
- Hazard Codes
- T
- Risk Statements
- 25-37/38-41-43
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 2811 6.1 / PGIII
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D5946
- Product name
- PD 150606
- Purity
- ≥97% (HPLC)
- Packaging
- 5mg
- Price
- $127
- Updated
- 2024/03/01
- Product number
- D5946
- Product name
- PD 150606
- Purity
- ≥97% (HPLC)
- Packaging
- 25mg
- Price
- $505
- Updated
- 2024/03/01
- Product number
- 13859
- Product name
- PD 150606
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 13859
- Product name
- PD 150606
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $332
- Updated
- 2024/03/01
- Product number
- 1269
- Product name
- PD 150606
- Purity
- ≥95%(HPLC)
- Packaging
- 10
- Price
- $173
- Updated
- 2021/12/16
3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID Chemical Properties,Usage,Production
Description
PD-150606 (179528-45-1) is a selective, cell-permeable non-peptide calpain inhibitor (Ki for μ- and m-calpains = 0.21 and 0.37 μM respectively). Acts at the calcium binding site of calpain rather than the substrate-binding site. Inhibits calpain activity in two intact cell systems. Attenuates hypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices.1 PD-150606 displays cytoprotective effects in oxidant- and calcium ionophore-induced cell death.2 Some protective effects may be due to inhibition of MMP activity.3
Uses
PD 150606 is a novel mercaptoacrylate based compound and a potent inhibitor of Ca2+-dependent activation of calpain-1, a Ca2+-activated cytosolic cysteine protease. PD 150606 may potentially be developed as an anti-inflammatory agent. Neuroprotective product.
Definition
ChEBI: An organoiodine compound that is acrylic acid in which the vinylic hydrogens at positions 2 and 3 are replaced by mercapto and 4-iodophenyl groups respectively (the Z geoisomer).
Biochem/physiol Actions
PD 150606 is a selective; cell-permeable; non-peptide; uncompetitive calpain inhibitor.
storage
Store at -20°C
References
1) Wang?et al. (1996),?An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective; Proc. Natl. Acad. Sci. USA,?93?6687 2) Waters?et al. (1997),?Calpains mediate calcium and chloride influx during the late phase of cell injury; J. Pharmacol. Exp. Therap.,?283?1177 3) Ali?et al. (2012), Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity; Biochem. Biophys. Res. Commun.,?423?1
3-(4-IODOPHENYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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