ChemicalBook > CAS DataBase List > 2-Methyl-3-trifluoromethylaniline

2-Methyl-3-trifluoromethylaniline

Product Name: 2-Methyl-3-trifluoromethylaniline
CAS No.: 54396-44-0
Chemical Name: 2-Methyl-3-trifluoromethylaniline
Synonyms: 2-METHYL-3-(TRIFLUOROMETHYL)ANILINE;3-AMINO-2-METHYLBENZOTRIFLUORIDE;MABTF;2-Methyl-3-trifluoro;Flunixin EP Impurity B;Flunixin impurity B CRS;Flunixin Related CoMpound B;Methyl-3-(trifluoroMethyl)an;3-TRIFLUOROMETHYL-O-TOLUIDINE;Methyl-3-trifluoromethylanili
CBNumber: CB6774574
Molecular Formula: C8H8F3N
Formula Weight: 175.15
MOL File: 54396-44-0.mol

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2-Methyl-3-trifluoromethylaniline Property

Melting point:: 38-42 °C(lit.)
Boiling point:: 62-64°C 4mm
Density: 1.237±0.06 g/cm3(Predicted)
Flash point:: >210 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Crystalline Powder
pka: 3.23±0.10(Predicted)
color: White
BRN: 2832865
InChI: InChI=1S/C8H8F3N/c1-5-6(8(9,10)11)3-2-4-7(5)12/h2-4H,12H2,1H3
InChIKey: TWLDBACVSHADLI-UHFFFAOYSA-N
SMILES: C1(N)=CC=CC(C(F)(F)F)=C1C
CAS DataBase Reference: 54396-44-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T,T+
Risk Statements: 36/37/38-26/27/28
Safety Statements: 26-36-24/25
RIDADR: 2811
WGK Germany: 3
Hazard Note: Toxic
HazardClass: IRRITANT
HazardClass: 6.1
HS Code: 29214990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000444
Product name: Flunixin impurity B
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 10 mg
Price: $225
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR2823
Product name: Flunixin Related Compound B
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 50MG
Price: $497
Updated: 2025/07/31

Sigma-Aldrich

Product number: 375705
Product name: 2-Methyl-3-(trifluoromethyl)aniline
Purity: 95%
Packaging: 1g
Price: $20.42
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1274630
Product name: Flunixin Related Compound B
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1200
Updated: 2025/07/31

TCI Chemical

Product number: M1328
Product name: 2-Methyl-3-trifluoromethylaniline
Purity: >99.0%(GC)
Packaging: 1g
Price: $31
Updated: 2025/07/31

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2-Methyl-3-trifluoromethylaniline Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

2-Methyl-3-trifluoromethylaniline is a reactant in the synthesis of methylguanidine derivatives as prospective PET radioligands for the open channel of the NMDA receptor, linked to Alzheimer’s, epilepsy and other neurodegenerative disorders.

General Description

2-Methyl-3-(trifluoromethyl)aniline belongs to the trifluoromethylbenzene series.

Synthesis

A method for synthesizing 2-methyl-3-trifluoromethyl aniline, which takes 2-chloro-3-trifluoromethyl aniline as a raw material, introduces methylthio on the 2-chloro-3-trifluoromethyl aniline, reacts with sulfonyl chloride to convert the methylthio into chloromethyl, and then neutralizes and hydrogenates to obtain pure 2-Methyl-3-trifluoromethylaniline.

References

[1] Patent: US5248781, 1993, A
[2] Heterocycles, 1994, vol. 38, # 10, p. 2243 - 2246

2-Methyl-3-trifluoromethylaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Methyl-3-trifluoromethylaniline manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: 2-Methyl-3-trifluoromethylaniline 54396-44-0
Price: US $30.00-10.00/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 100000kg
Release date: 2024-08-20

Hangzhou ICH Biofarm Co., Ltd

Product: 2-Methyl-3-trifluoromethylaniline (MTA) 54396-44-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.0% min
Supply Ability: 10tons/month
Release date: 2023-06-12

TAIZHOU DKD CHEMICAL CO., LTD.

Product: 2-Methyl-3-trifluoromethylaniline 54396-44-0
Price: US $0.00/kg
Min. Order: 25kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2022-11-09

54396-44-0, 2-Methyl-3-trifluoromethylaniline Related Search:

(Trifluoromethyl)trimethylsilane o-Toluidine 4-(Trifluoromethoxy)aniline N,N-Dimethyl-1,4-phenylenediamine N,N-Dimethylaniline Kresoxim-methyl Methyl acrylate Methyl acetate Glycine 6-Aminocaproic acid 3-Aminophenol Bensulfuron methyl Methylparaben 3-Aminobenzotrifluoride ALTRENOGEST 3,3',5,5'-Tetramethylbenzidine dihydrochloride Thiophanate-methyl Tris(hydroxymethyl)aminomethane

MABTF

2-METHYL-3-(TRIFLUOROMETHYL)ANILINE

2-METHYL-3-TRIFLUOROMETHYL-PHENYLAMINE

3-TRIFLUOROMETHYL-O-TOLUIDINE

3-PERFLUOROMETHYL-2-METHYLANILINE

3-AMINO-2-METHYLBENZOTRIFLUORIDE

2-Methyl-3-Amino Benzotrifluoride

2-methyl-3-thifluoromethylaniline

2-methyl-3-trifluoromethylaniline(MTA)

2-Amino-6-trifluoromethyl toluene

2-Methyl-3-(trifluoromethyl)benzenamine

2-Methyl-3-Trifluoromethylaniline/2-Methyl-3-(Trifluoromethyl)Benzenamine

2-Methyl-3-Trifluoromethylanil

2-methyl-3-trifluoromethylaniline (intermediate of flunixin)

3-Amino-2-methylbenzotrifluoride 98%

Flunixin Meglumine EP Impurity B

3-Amino-2-methylbenzotrifluoride98%

2-METHYL-3-TRIFLUOROMETHYLANILINE (3-AMINO-2-METHYLBENZOTRIFLUORIDE)

3-Trifluoromethyl-2-methylaniline

2-Methyl-3-trifluoromethylaniline (3-Amino-2-methylbenzotrifluor

3-Amino-2-methylbenzotrifluoride 3-Trifluoromethyl-o-toluidine

2-Methyl-3-trifluoro

Flunixin Related CoMpound B

Methyl-3-(trifluoroMethyl)an

2-Methyl-3- threetrifluoroMethylaniline

BenzenaMine,2-Methyl-3-(trifluoroMethyl)-

Methyl-3-trifluoromethylaniline

Flunixin Meglumine Impurity 2（Flunixin Meglumine EP Impurity B）

Flunixin impurity B CRS

2-Methyl-3-trifluoromethylaniline&gt

Flunixin EP Impurity B

Amino-2-methylbenzotrifluoride

2-METHYL-3-TRIFLUOROMETHYLANILINE 54396-44-0

2-methyl-3(trifluoromethyl) aniline (ATFT)

Flunixin impurity BQ: What is Flunixin impurity B Q: What is the CAS Number of Flunixin impurity B Q: What is the storage condition of Flunixin impurity B Q: What are the applications of Flunixin impurity B

Flunixin Related Compound B (2-Methyl-3-(trifluoromethyl)aniline) (1274630)

Methyl-3-trifluoromethylanili

Flunixin USP Related Compound B

Flunixin Meglumine Impurity B

Flunixin Meglumine Impurity 5

54396-44-0

54369-44-0

CH3C6H3CF3NH2

Organic Building Blocks

Nitrogen Compounds

Building Blocks

Amines

Nitrogen Compounds

API intermediates

Trifluoromethylbenzene serise