ChemicalBook > CAS DataBase List > [Hydroxy(tosyloxy)iodo]benzene

[Hydroxy(tosyloxy)iodo]benzene

Product Name
[Hydroxy(tosyloxy)iodo]benzene
CAS No.
27126-76-7
Chemical Name
[Hydroxy(tosyloxy)iodo]benzene
Synonyms
HTIB;HYDROXY(TOSYLOXY)IODOBENZENE;Koser Reagent;[hydroxy(phenyl)-λ3-iodanyl] 4-methylbenzenesulfonate;NSC 294176;AKOS 91494;Koser's Regent;[Hydroxy(tosyL;KOSER'S REAGENT;KOSER'S REAGENT
CBNumber
CB6778895
Molecular Formula
C13H13IO4S
Formula Weight
392.21
MOL File
27126-76-7.mol
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[Hydroxy(tosyloxy)iodo]benzene Property

Melting point:
131-137 °C (lit.)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in Methanol
form 
Crystalline Powder
pka
7.59±0.58(Predicted)
color 
Pale yellow
Sensitive 
Light Sensitive
Merck 
14,5321
BRN 
2150074
InChIKey
LRIUKPUCKCECPT-UHFFFAOYSA-N
CAS DataBase Reference
27126-76-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/38
Safety Statements 
26-36
WGK Germany 
3
F 
8
HazardClass 
IRRITANT
HS Code 
29039990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
301035
Product name
[Hydroxy(tosyloxy)iodo]benzene
Purity
96%
Packaging
5g
Price
$33.84
Updated
2024/03/01
Sigma-Aldrich
Product number
301035
Product name
[Hydroxy(tosyloxy)iodo]benzene
Purity
96%
Packaging
25g
Price
$162
Updated
2024/03/01
TCI Chemical
Product number
P1015
Product name
[Hydroxy(tosyloxy)iodo]benzene
Purity
>97.0%(T)
Packaging
5g
Price
$92
Updated
2024/03/01
TCI Chemical
Product number
P1015
Product name
[Hydroxy(tosyloxy)iodo]benzene
Purity
>97.0%(T)
Packaging
25g
Price
$375
Updated
2024/03/01
Alfa Aesar
Product number
L15701
Product name
Hydroxy(tosyloxy)iodobenzene, 97%
Packaging
5g
Price
$37.65
Updated
2024/03/01
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[Hydroxy(tosyloxy)iodo]benzene Chemical Properties,Usage,Production

Chemical Properties

Pale yellow crystalline powder

Uses

Reactant for:

  • Ligand-free palladium-catalyzed Heck-type coupling reactions
  • Preparation of carbodiimides via dehydrosulfurization of thioureas
  • Preparation of nitriles by oxidative conversion of alcohols, aldehydes, and amines
  • Preparation of substituted anilines via aromatic aldoxime reaction
  • Preparation of tetrahydrofurans by oxidative cyclization of homoallylic alcohols
  • Preparation of isoxazoline N-Oxides from ?-hydroxyketoximes via oxidative N-O coupling
  • Ring expansion in synthesis of aminopeptidase inhibitors
  • Oxidation and protonation reactions in acidic conditions

Uses

Versatile synthetic reagent in phenyliodination and/or tosylation of a range of organic substrates; in oxidative transformations including oxidative rearrangements.

Purification Methods

Possible impurities are tosic acid (removed by washing with Me2CO) and acetic acid (removed by washing with Et2O). It is purified by dissolving in the minimum volume of MeOH, adding Et2O to cloud point and setting aside for the prisms to separate [Koser & Wettach J Org Chem 42 1476 1977, NMR: Koser et al. J Org Chem 41 3609 1976]. It has also been crystallised from CH2Cl2 (needles, m 140-142o) [Neiland & Karele J Org Chem, USSR (Engl Transl) 6 889 1970].

[Hydroxy(tosyloxy)iodo]benzene Preparation Products And Raw materials

Raw materials

Preparation Products

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[Hydroxy(tosyloxy)iodo]benzene Suppliers

Americas 1 Belgium 2 China 178 Europe 3 France 1 Germany 6 India 9 Japan 1 Poland 1 Switzerland 2 United Kingdom 9 United States 25 Global 238
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View Lastest Price from [Hydroxy(tosyloxy)iodo]benzene manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
[Hydroxy(tosyloxy)iodo]benzene 27126-76-7
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-16
hebei hongtan Biotechnology Co., Ltd
Product
[Hydroxy(tosyloxy)iodo]benzene 27126-76-7
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-05-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
Hydroxy(tosyloxy)iodobenzene 27126-76-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

27126-76-7, [Hydroxy(tosyloxy)iodo]benzeneRelated Search:

Butylated Hydroxytoluene Benzene Ethylbenzene Tosyl chloride Tosyl cyanide Allylbenzene p-Toluenesulfonamide Fipronil CHLOROPHOSPHONAZO III TOLBUTAMIDE Iodosobenzene 2-(4-Aminopentyl(ethyl)amino)ethanol HYDROXY ITRACONAZOLE Hydroxyacetic Acid Hydrazide Iodobenzene [Hydroxy(tosyloxy)iodo]benzene [HYDROXY(METHANESULFONYLOXY)IODO]BENZENE 1-[[(4-METHYLPHENYL)SULPHONYL]OXY]-1,2-BENZIODOXOL-3(1H)-ONE

  • Iodine,hydroxy(4-Methylbenzenesulfonato-kO)phenyl-
  • [Hydroxy(tosyloxy)iodo]benzene 96%
  • [Hydroxy(4-toluenesulfonato)iodo]benzene
  • Hydroxy(phenyl)iodo tosylate
  • [Hydroxy(tosyloxy)iodo]benzene≥ 98%(Titration)
  • Hydroxy{[(4-methylphenyl)sulfonyl]oxy} phenyliodine
  • Koser's Regent ,HTIB
  • Hydroxyl(toluenesulfonyloxygengeneration)iodobenzene
  • NSC 294176
  • Phenyliodosyl hydroxide tosylate
  • [hydroxy(phenyl)-λ3-iodanyl] 4-methylbenzenesulfonate
  • HYDROXY(4-METHYLBENZENESULFONATO-O)PHENYLIODINE
  • IODOSOBENZENE-I-MONO-P-TOLUENESULFONATE
  • IODOSOBENZENE-L-MONO-4-TOLUENESULFONATE
  • KOSER'S REAGENT
  • LABOTEST-BB LT00453060
  • AKOS 91494
  • HTIB~Iodosobenzene-I-mono-p-toluenesulphonate~Kosers
  • Iodosobenzene-I-mono-p-toluenesulfonate, Koser's Reagent
  • Hydroxy(tosyloxy)iodobenzene,97%
  • Koser's Regent
  • Hydroxy{[(4-methylphenyl)sulfonyl]oxy}phenyliodine (HTIB)
  • Hydroxy(4-methylbenzenesulfonato-O)phenyliodine, Iodosobenzene-I-mono-p-toluenesulfonate, Kosers reagent
  • 4-Methylbenzenesulfonic acid hydroxyphenyliodine(III) salt
  • [Hydroxy(tosyL
  • oxy)iodo]benzene
  • 4-Methylbenzenesulfonic acid hydroxyphenyliodo(III) ester
  • Hydroxytosyloxyphenyliodine(III)
  • Phenylhydroxy(p-tolylsulfonyloxy) iodine(III)
  • HTIB
  • Hydroxy(tosyloxy)iodo]benzene,Koser's　Reagent
  • HTIB [Hydroxy(tosyloxy)iodo]benzene
  • [Hydroxy(tosyloxy)iodo]benzene, 97+% 5GR
  • Phenyliodosohydroxy Tosylate Koser Reagent
  • Hydroxy[(p-tolylsulfonyl)oxy]iodo benzene
  • 2-hydroxy-6-iodophenyl 4-Methylbenzenesulfonate
  • PHENYLIODOSOHYDROXY TOSYLATE
  • HYDROXY(TOSYLOXY)IODOBENZENE
  • Iodine, hydroxy(4-methylbenzenesulfonato-O)phenyl-
  • Koser Reagent
  • [hydroxy(phenyl)-λ<sup>3</sup>-iodanyl] 4-methylbenzenesulfonate
  • [Hydroxy(tosyloxy)iodo]benzene(HTIB)
  • 4-methylbenzenesulfonic acid (2-hydroxy-6-iodophenyl) ester
  • [Hydroxy(tosyloxy)iodo]benzene&gt
  • hydroxy(phenyl)-l3-iodaneyl 4-methylbenzenesulfonate
  • KOSER'S REAGENT
  • 27126-76-7
  • 2126-76-7
  • C13H13IO4S
  • CH3C6H4SO3IOHC6H5
  • Hypervalent Iodine
  • Synthetic Reagents
  • Hypervalent Iodine Compounds
  • Oxidation
  • Hypervalent Iodine Compounds
  • Oxidation
  • Synthetic Organic Chemistry
  • Phenyls & Phenyl-Het