ORPHENADRINE HYDROCHLORIDE

ChemicalBook > CAS DataBase List > ORPHENADRINE HYDROCHLORIDE

ORPHENADRINE HYDROCHLORIDE

Product Name: ORPHENADRINE HYDROCHLORIDE
CAS No.: 341-69-5
Chemical Name: ORPHENADRINE HYDROCHLORIDE
Synonyms: BF 5930;BG 5930;BS 5930;Mebedrol;Mephenamin;Brocasipal;Mephenamine;Brocadisipal;mephenaminforte;Mephenamin forte
CBNumber: CB6782740
Molecular Formula: C18H24ClNO
Formula Weight: 305.84
MOL File: 341-69-5.mol

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ORPHENADRINE HYDROCHLORIDE Property

Melting point:: 159.0 to 164.0 °C
Boiling point:: -195 °C
Density: 0.295 g/cm3
storage temp.: 2-8°C
solubility: Freely soluble in water and in ethanol (96 per cent).
color: Crystals
BRN: 3745818
Stability:: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference: 341-69-5(CAS DataBase Reference)
EPA Substance Registry System: Orphenadrine hydrochloride (341-69-5)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
RIDADR: 3249
WGK Germany: 3
RTECS: KR6300000
HazardClass: 6.1(b)
PackingGroup: III
Toxicity: LD50 oral in rat: 255mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000100
Product name: Orphenadrine hydrochloride
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000100
Price: $150
Updated: 2024/03/01

Sigma-Aldrich

Product number: 75517
Product name: Orphenadrine hydrochloride
Purity: 99%
Packaging: 5g
Price: $64.2
Updated: 2024/03/01

Cayman Chemical

Product number: 26391
Product name: Orphenadrine (hydrochloride)
Packaging: 10mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 26391
Product name: Orphenadrine (hydrochloride)
Packaging: 25mg
Price: $115
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0001181
Product name: Orphenadrine for peak identification
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001181
Price: $203
Updated: 2024/03/01

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ORPHENADRINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder.

Uses

Antihistaminic;H1 antogonist

Definition

ChEBI: A hydrochloride comprising equimolar amounts of ophenadrine and hydrogen chloride.

General Description

Odorless white or almost white crystalline powder. pH (aqueous solution) about 5.5. Bitter numbing taste.

Air & Water Reactions

May be sensitive to prolonged exposure to light and air. Water soluble.

Reactivity Profile

ORPHENADRINE HYDROCHLORIDE is incompatible with strong oxidizers.

Fire Hazard

Flash point data for ORPHENADRINE HYDROCHLORIDE are not available; however, ORPHENADRINE HYDROCHLORIDE is probably combustible.

Biochem/physiol Actions

Muscarinic receptor antagonist; H1 histamine receptor antagonist; muscle relaxant. Orphenadrine has also been reported to inhibit the noradrenergic transporter and to block the NMDA receptor ion channel.

Clinical Use

Anti-muscarinic:
Parkinsonism
Drug induced extra-pyramidal symptoms

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects: mydriasis @updlaryd ilation), hallucinations, distorted perceptions, pulse rate increase, intracranial pressure increase. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl

Metabolism

Orphenadrine is almost completely metabolised to at least 8 metabolites in the liver.
It is mainly excreted in the urine as metabolites and small amounts of unchanged drug

ORPHENADRINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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341-69-5, ORPHENADRINE HYDROCHLORIDERelated Search:

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orfenadrinhydrochloride

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2-(PHENYL-O-TOLYLMETHOXY)ETHYLDIMETHYLAMINE HYDROCHLORIDE

ORPHENADRINE HCL

ORPHENADRINE HYDROCHLORIDE

O-METHYLDIPHENHYDRAMINE HYDROCHLORIDE

N,N-DIMETHYL-2-(2-METHYLBENZHYDRYLOXY)-ETHYLAMINE HYDROCHLORIDE

B-DIMETHYLAMINOETHYL 2-METHYLBENZHYDRYL ETHER HYDROCHLORIDE

n,n-dimethyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-ethylaminhydrochloride

N,N-Dimethyl-2-(alpha-(o-tolyl)benzyloxy)ethylamine hydrochloride

N,N-Dimethyl-2-(o-methyl-alpha-phenylbenzyloxy)ethylamine hydrochloride

o-Methyldiphenhydramine hydrochloride, N,N-Dimethyl-2-(2-methylbenzhydryloxy)ethylamine hydrochloride, β-Dimethylaminoethyl 2-methylbenzhydryl ether hydrochloride

Orphenadrine hydrochloride,99%

Orphenadrine hydrochloride CRS

OrphenadrineHydrochloride&gt

ORPHENADRINE HYDROCHLORIDE ISO 9001：2015 REACH

Ionotropic glutamate receptors,Orphenadrine hydrochloride,spasticity,HSP27,parkinson's syndrome,PBR,Inhibitor,inhibit,CGC cells,iGluR,neuroprotective properties,Orphenadrine

Orphenadrine Hydrochloride, ≥ 98.0%

Orphenadrine hydrochloride in methanol

Phenylbutazone Impurity 20

341-69-5

C18H23NOHCl

Building Blocks

Amine Salts

Nitrogen Compounds

Organic Building Blocks

API