ChemicalBook > CAS DataBase List > Sutimlimab
Sutimlimab
- Product Name
- Sutimlimab
- CAS No.
- 2049079-64-1
- Chemical Name
- Sutimlimab
- Synonyms
- Sutimlimab;Sutimlimab (DHC43601);Sutimlimab (anti-C1s);Research Grade Sutimlimab;Research Grade Sutimlimab(DHC43601)
- CBNumber
- CB68081078
- Formula Weight
- 0
- MOL File
- Mol file
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Sutimlimab Property
- storage temp.
- Store at -20°C
- form
- Liquid
- color
- Colorless to light yellow
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Sutimlimab Chemical Properties,Usage,Production
Uses
Sutimlimab, a first-in-class complement protein component 1, s subcomponent (C1s) inhibitor, can be used for the research of cold agglutinin disease. C1s is a serine protease which cleaves C4 and C2 to form the C3 convertase[1].
Biological Activity
Sutimlimab, a first-in-class humanized immunoglobulin G4 (IgG4) monoclonal antibody that selectively inhibits the classical complement pathway at C1s, rapidly halted hemolysis in the single-arm CARDINAL study in recently transfused patients with cold agglutinin disease (CAD).
References
[1] Alexander R?th, et al. Sutimlimab in Cold Agglutinin Disease. N Engl J Med. 2021 Apr 8;384(14):1323-1334. DOI:10.1056/NEJMoa2027760
Sutimlimab Preparation Products And Raw materials
Raw materials
Preparation Products
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Sutimlimab Suppliers
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