Anatibant

Product Name: Anatibant
CAS No.: 209733-45-9
Chemical Name: Anatibant
Synonyms: anatibant;Unii-clo4jrd21f;Anatibant [inn];(2s)-n-(3-(4-carbamimidoylbenzamido)propyl)-1-(2,4-dichloro-3-((2,4-dimethyl-8-quinolyloxy)methyl)phenylsulfonyl)pyrrolidine-2-carboxamide;(S)-N-(3-(4-Carbamimidoylbenzamido)propyl)-1-((2,4-dichloro-3-(((2,4-dimethylquinolin-8-yl)oxy)methyl)phenyl)sulfonyl)pyrrolidine-2-carboxamide;2-PYRROLIDINECARBOXAMIDE, N-[3-[[4-(AMINOIMINOMETHYL)BENZOYL]AMINO]PROPYL]-1-[[2,4-DICHLORO-3-[[(2,4-DIMETHYL-8-QUINOLINYL)OXY]METHYL]PHENYL]SULFONYL]-, (2S)-
CBNumber: CB6855327
Molecular Formula: C34H36Cl2N6O5S
Formula Weight: 711.66
MOL File: 209733-45-9.mol

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Anatibant Property

Density: 1.44±0.1 g/cm3(Predicted)
pka: 14.09±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0024289
Product name: ANATIBANT
Purity: 95.00%
Packaging: 5MG
Price: $497.13
Updated: 2021/12/16

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Anatibant Chemical Properties,Usage,Production

Uses

Anatibant (LF 16-0687; XY-2405) is a selective non-peptide bradykinin B2 receptor antagonist. Anatibant binds to the human, rat and guinea-pig recombinant B2 receptor with Ki values of 0.67 nM, 1.74 nM and 1.37 nM, respectively. Anatibant crosses the blood-brain barrier (BBB). Anatibant can be used in research on brain damage diseases[1][2].

Definition

ChEBI: Anatibant is a proline derivative.

in vivo

Anatibant (3 mg/kg; subcutaneous bolus; injection 15 min and 8 h after trauma, respectively) significantly reduces intracranial pressure (ICP) and of contusion volume 24 h after trauma in treated mice^[1].

Animal Model:	Male C57/Bl6 mice (25-28 g) were subjected to Controlled Cortical Impact trauma (CCI)^[1]
Dosage:	3 mg/kg
Administration:	Subcutaneous bolus; injection 15 min and 8 h after trauma, respectively
Result:	Demonstrated a significant reduction of ICP and of contusion volume 24 h after trauma in treated mice.

IC 50

Bradykinin B2 Receptor (B2R): 0.67 nM (Ki, human recombinant B2 receptor); Bradykinin B2 Receptor (B2R): 1.74 nM (Ki, Rat recombinant B2 receptor); Bradykinin B2 Receptor (B2R): 1.37 nM (Ki, Guinea-pig recombinant B2 receptor)

References

[1] Klaus Zweckberger, et al. Anatibant, a selective non-peptide bradykinin B2 receptor antagonist, reduces intracranial hypertension and histopathological damage after experimental traumatic brain injury. Neurosci Lett. 2009 Apr 24;454(2):115-7. DOI:10.1016/j.neulet.2009.02.014
[2] D Pruneau, et al. Pharmacological profile of LF 16-0687, a new potent non-peptide bradykinin B2 receptor antagonist. Immunopharmacology. 1999 Sep;43(2-3):187-94. DOI:10.1016/s0162-3109(99)00128-9

Anatibant Preparation Products And Raw materials

Raw materials

Preparation Products

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Anatibant Suppliers

China 6 United States 8 Global 14

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
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SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD

Tel: 13816107857
Fax: qq: 276312098
Email: sales@fortunechem-sh.com
Country: China
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Chengdu Saint - Kay Biotechnology Co., Ltd.

Tel: 028-85157043 15882256948
Email: 676046971@qq.com
Country: China
ProdList: 4181
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
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Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3934
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CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
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TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29423
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Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
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TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 19962
Advantage: 58

209733-45-9, AnatibantRelated Search:

N,N-Dimethylformamide Dimethyl sulfoxide N,N-Dimethylallylamine Dimethyl fumarate Propyl gallate Dacthal Dimethyl carbonate Propyl butyrate Chlorantraniliprole Benzamide ETHANE Dimethyl ether Dimethyl sulfate Anatibant 4-AMINOMETHYL BENZAMIDINE DIHYDROCHLORIDE 4-FORMYL BENZAMIDINE HCL 4-AMIDINOBENZAMIDE HYDROCHLORIDE

anatibant

(2s)-n-(3-(4-carbamimidoylbenzamido)propyl)-1-(2,4-dichloro-3-((2,4-dimethyl-8-quinolyloxy)methyl)phenylsulfonyl)pyrrolidine-2-carboxamide

2-PYRROLIDINECARBOXAMIDE, N-[3-[[4-(AMINOIMINOMETHYL)BENZOYL]AMINO]PROPYL]-1-[[2,4-DICHLORO-3-[[(2,4-DIMETHYL-8-QUINOLINYL)OXY]METHYL]PHENYL]SULFONYL]-, (2S)-

Anatibant [inn]

Unii-clo4jrd21f

(S)-N-(3-(4-Carbamimidoylbenzamido)propyl)-1-((2,4-dichloro-3-(((2,4-dimethylquinolin-8-yl)oxy)methyl)phenyl)sulfonyl)pyrrolidine-2-carboxamide

209733-45-9

C34H36Cl2N6O5S