ChemicalBook > CAS DataBase List > 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid

3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid

Product Name
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid
CAS No.
2458-08-4
Chemical Name
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid
Synonyms
Einecs 219-542-6;12-Oxocholic acid;Ursodiol Impurity;Cholic Acid Impurity 16;1,3-dimethyl-38-nitrosourea;12-Ketochenodeoxycholic acid;Ursodeoxycholic Acid Impurity 23;Chenodeoxycholic Acid Impurity 10;3,7-Dihydroxy-12-oxocholanoic acid;3α,7α-Dihydroxy-12-oxocholanic acid
CBNumber
CB6890359
Molecular Formula
C24H38O5
Formula Weight
406.56
MOL File
2458-08-4.mol
More
Less

3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid Property

Boiling point:
583℃[at 101 325 Pa]
Density 
1.18[at 20℃]
vapor pressure 
0Pa at 20℃
storage temp. 
-20°C
solubility 
Chloroform: Slightly Soluble
Methanol: Slightly Soluble
pka
5[at 20 ℃]
form 
Solid
color 
White to off-white
Water Solubility 
4.698mg/L at 25℃
LogP
2.97 at 20℃
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More
Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
SHG0020695
Product name
KETOCHOLANIC ACID
Purity
95.00%
Packaging
5MG
Price
$459.63
Updated
2021/12/16
More
Less

3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid Chemical Properties,Usage,Production

Uses

12-Ketochenodeoxycholic acid 12 is a direct precursor of cholodeoxycholic acid (CDCA). Cholodeoxycholic acid is used to cholesterol gallstones and has chemotherapeutic properties that dissolve gallstones[1].

Definition

ChEBI: 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanic acid is an oxo-5beta-cholanic acid. It is a conjugate acid of a 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate.

Flammability and Explosibility

Non flammable

References

[1] Sawada, H. et al. Microbial production of chenodeoxycholic acid precursor, 12-ketochenodeoxycholic acid, from dehydrocholic acid. European Journal of Applied Microbiology and Biotechnology, 10(1–2), 107–112.
[2] J D SUTHERLAND  T P F  I A Macdonald. The enzymic and chemical synthesis of ursodeoxycholic and chenodeoxycholic acid from cholic acid.[J]. Preparative biochemistry, 1982, 12 4: 307-321. DOI: 10.1080/00327488208065679
[3] A. HOFMANN. The Preparation of Chenodeoxycholic Acid and Its Glycine and Taurine Conjugates.[J]. Acta chemica Scandinavica, 1963, 177 1: 173-186. DOI: 10.3891/acta.chem.scand.17-0173
[4] AIHUA ZHAO. Increased levels of conjugated bile acids are associated with human bile reflux gastritis.[J]. Scientific Reports, 2020: 11601. DOI: 10.1038/s41598-020-68393-5
[5] YIZHONG WANG. Altered gut microbiota and microbial metabolism in children with hepatic glycogen storage disease: a case-control study.[J]. Translational pediatrics, 2023, 12 4: 572-586. DOI: 10.21037/tp-22-293
[6] MOMIR MIKOV. 3Alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate as blood-brain barrier permeator.[J]. Polish journal of pharmacology, 2004, 56 3: 367-371.
[7] MIHALJ POSA. Effect of cholic acid and its keto derivatives on the analgesic action of lidocaine and associated biochemical parameters in rats.[J]. European Journal of Drug Metabolism and Pharmacokinetics, 2007, 32 2: 109-117. DOI: 10.1007/bf03190999

3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid Suppliers

China 49 India 1 United States 2 Global 52
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16075
Advantage
64
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Beijing OKA biological technology co., LTD
Tel
010-62971590 18548936886
Fax
010-62340519
Email
3462612863@qq.com
Country
China
ProdList
10063
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Shenzhen Botel Biotechnology Co. Ltd.
Tel
13316949107 13316968096
Email
1979313431@qq.com
Country
China
ProdList
9564
Advantage
58
TOSUN PHARM
Tel
020-61855200 13326451905
Email
260366801@qq.com
Country
China
ProdList
7924
Advantage
58
Guangzhou Dreampharm Biotechnology Co., Ltd.
Tel
020-36607679 19925672674
Fax
QQ 3008233717
Email
3008233746@qq.com
Country
China
ProdList
9883
Advantage
12
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
Shanghai Keke Biotechnology Co., Ltd.
Tel
021-34975789 18721102763
Email
click@click-biotech.com
Country
China
ProdList
300
Advantage
58
Shandong WorldSun Biological Technology Co., Ltd.
Tel
0531-88723173 18596073690
Email
1047208234@qq.com
Country
China
ProdList
6779
Advantage
58
Hubei Xinyang Medical Technology Co., Ltd
Tel
15347293736
Fax
QQ：2853117752
Email
2853117764@yongstandards.com
Country
China
ProdList
9997
Advantage
58
Guangzhou Juntang Technology Co., Ltd
Tel
020-36607679 13502246435
Email
sales@dmstandards.com
Country
China
ProdList
10945
Advantage
58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
029-029-029-81148696 18161915376
Email
1040@dideu.com
Country
China
ProdList
10001
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81960175-877 18933936954
Email
tianwen.zhan@cato-chem.com
Country
China
ProdList
7259
Advantage
58
Shanghai Saikerui Biotechnology Co. , Ltd.
Tel
021-58000709 15900491054
Email
info@scrbio.com
Country
China
ProdList
9881
Advantage
58
LangFangshi Zekang Pharma Tech CO.,Itd.
Tel
0316-2883536 19333636468
Email
93618484@qq.com
Country
China
ProdList
2334
Advantage
58
Shanghai Beiwanta Biotechnology Co., Ltd.
Tel
021-67187366 19901745723
Email
info@bwtlab.com
Country
China
ProdList
9651
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-025-66113011 18626450290
Email
cb5@aikonchem.com
Country
China
ProdList
10358
Advantage
58
Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd
Tel
18162595016; 18162595016
Email
3287908757@qq.com
Country
China
ProdList
9119
Advantage
58
Shochem (Shanghai) Co.,Ltd
Tel
13611745246 13816874662
Email
sales@shochem.com
Country
China
ProdList
534
Advantage
58
Hubei Moco Chemical Co., Ltd.
Tel
18627753421; 18627756402
Fax
QQ：3001051413
Email
3001051413@qq.com
Country
China
ProdList
20319
Advantage
58
SHANGHAI ZZBIO CO., LTD.
Tel
15102117276 19921389125
Email
tech@zzbioco.com
Country
China
ProdList
12064
Advantage
58
TLC Pharmaceutical Standards Ltd.
Tel
18012923235; 18012923235
Email
chinasales04@tlcstandards.com.cn
Country
China
ProdList
7975
Advantage
58
BePure (Beijing) Biotechnology Co.
Tel
58896805
Email
7993601name@qq.com
Country
CHINA
ProdList
6620
Advantage
58
Hubei Ruinuo Pharmaceutical Technology Co., Ltd
Tel
0714-5316360; 13165688766
Fax
0714-5316360
Email
3008058303@qq.com
Country
China
ProdList
3000
Advantage
58
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
028-81700200 13308200041
Email
2851167782@qq.com
Country
China
ProdList
11146
Advantage
58
Hunan Hui Bai Yi New Materials Co., Ltd
Tel
0745-2866551 19976851779
Email
3002713163@qq.com
Country
China
ProdList
7333
Advantage
58
Shanghai Weiyite Biotechnology Co., Ltd
Tel
15317051735
Email
zhaojing@wytsci.com
Country
China
ProdList
9980
Advantage
58
Chengdu DeSiTe Biological Technology Co., Ltd
Tel
17308096051
Email
3001048290@qq.com
Country
China
ProdList
6219
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Enzo Biochem Inc
Tel
Enzo Biochem Inc. 13797054060
Email
Enzoname@qq.com
Country
China
ProdList
6174
Advantage
58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
Advantage
58
Sichuan jiayinglai technology CO.,LTD
Tel
028-64159575
Email
1678230860@qq.com
Country
China
ProdList
6511
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
ShangHai ZskBio CO., LTD
Tel
021-58056897 15399714481
Email
info@zsklab.com
Country
China
ProdList
7190
Advantage
58
LangFangshi Hengfuyuan Pharma Tech CO.,Itd.
Tel
0316-2883536 19333636468
Email
1877241811@qq.com
Country
China
ProdList
2181
Advantage
58
Henan Tianfu Chemical Co.,Ltd.
Tel
+86-0371-55170693 +86-19937530512
Fax
0371-55170693
Email
info@tianfuchem.com
Country
China
ProdList
21612
Advantage
55
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.
Tel
+8618950047208
Email
ellena@amitychem.com
Country
China
ProdList
43416
Advantage
58
Moxin Chemicals
Tel
+86-17320513646 +8617320513646
Email
anna@molcoo.com
Country
China
ProdList
10000
Advantage
58
China National Standard Pharmaceutical Corporation Limited
Tel
+8615391658522
Email
overseasales@yongstandards.com
Country
China
ProdList
11922
Advantage
58
Guangzhou Keyuan Instrument Equipment Co., Ltd.
Tel
13725272260
Country
CHINA
ProdList
113
Advantage
58
Neobioscience Co., Ltd.
Tel
--
Fax
--
Email
info@neobioscience.com
Country
CHINA
ProdList
6207
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58

2458-08-4, 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acidRelated Search:

1β,3α,7β-Trihydroxy-5β-cholanic Acid Ursodeoxycholic acid EP Impurity M Chenodeoxycholic acid 4-[(5S,7S,8S,10S,13R,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid (4R)-4-[(3R,5R,8R,9S,10S,12R,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid URSODEOXYCHOLIC-2,2,4,4-D4 ACID Deoxyursocholic acid methyl ester (5a,7b)-7-hydroxy-3-oxo-Cholan-24-oic acid 7-Oxyisotithocholic Acid 3alpha-Hydroxy-7-oxo-5beta-cholanic Acid LITHOCHOLIC ACID 3,7-DIKETO-5BETA-CHOLAN-24-OIC ACID (3a,5b,7a,12b)-3,7,12-trihydroxy-Cholan-24-oic acid Ursodeoxycholic acid (3α,5β,7β)- 3,7,22-Trihydroxycholan-24-oic Acid α-Muricholic Acid (3b,5b,7a,12a)-3,7,12-trihydroxy-Cholan-24-oic acid (4R)-4-[(3S,5S,7S,8S,9S,10R,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid

  • 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid
  • 3,7-Dihydroxy-12-oxocholanoic acid
  • 12-Ketochenodeoxycholic acid
  • 12-Oxocholic acid
  • 3α,7α-Dihydroxy-12-oxocholanic acid
  • Cholan-24-oic acid, 3,7-dihydroxy-12-oxo-, (3 alpha,5 beta,7 alpha)-
  • Einecs 219-542-6
  • Chenodeoxycholic Acid Impurity 10
  • Cholic Acid Impurity 8 (12-Oxochenodeoxycholic Acid)
  • 5β-CHOLANIC acid-3α, 7α-DIOL-12-ONE
  • Ursodeoxycholic Acid Impurity 23
  • Cholan-24-oic acid,3,7-dihydroxy-12-oxo-, (3a,5b,7a)-
  • 3α,7α-dihydroxy-12-oxo-5β-cholanic acid
  • Cholic Acid Impurity 16
  • Chenodeoxycholic Acid EP Impurity H
  • (R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-12-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
  • 3-a,7-a-dihydroxy-12-0x0-53-cholan-24-oic acid
  • 1,3-dimethyl-38-nitrosourea
  • Chenodeoxycholic Acid EP Impurity H (12-Oxochenodeoxycholic Acid)
  • Ursodiol Impurity
  • 3α,7α-dihydroxy-12-oxo-5β-cholan-24-oic acid
  • 3α,7α-Dihydroxy-12-Ketocholanic Acid
  • (3ALPHA,5BETA,7ALPHA)-3,7-DIHYDROXY-12-OXOCHOLAN-24-OIC ACID
  • 2458-08-4