ChemicalBook > CAS DataBase List > methyl D-prolinate

methyl D-prolinate

Product Name
methyl D-prolinate
CAS No.
43041-12-9
Chemical Name
methyl D-prolinate
Synonyms
Proline Impurity 1;methyl D-prolinate
CBNumber
CB6926586
Molecular Formula
C6H11NO2
Formula Weight
129.16
MOL File
43041-12-9.mol
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methyl D-prolinate Property

Boiling point:
169.9±33.0 °C(Predicted)
Density 
1.055±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka
8.23±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
AAA0004589
Product name
(R )-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER
Purity
95.00%
Packaging
5MG
Price
$504
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
AAA0004589
Product name
(R )-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER
Purity
95.00%
Packaging
1G
Price
$588
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
52836
Product name
D-ProlineMethylEster
Packaging
10g
Price
$1250
Updated
2021/12/16
Chemenu
Product number
CM193313
Product name
methylD-prolinate
Purity
95%
Packaging
100g
Price
$1767
Updated
2021/12/16
Chemenu
Product number
CM193313
Product name
methylD-prolinate
Purity
95%
Packaging
500g
Price
$4574
Updated
2021/12/16
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methyl D-prolinate Chemical Properties,Usage,Production

Uses

D-Proline Methyl Ester, is a building block used for the synthesis of pharmaceutical compounds, such as Eletriptan (E505000) acting as an Antimigrene.

Synthesis

67-56-1

609-36-9

43041-12-9

Thionyl chloride (0.75 mL, 10.43 mmol) was slowly added to a stirred solution of DL-proline (1 g, 8.69 mmol) in methanol (10 mL). The reaction mixture was heated to reflux temperature and stirred continuously for 16 hours. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was concentrated and the residue was dissolved in dichloromethane (15 mL). Solid sodium bicarbonate was added to quench the excess thionyl chloride, and after filtration, the filtrate was concentrated under reduced pressure to afford methyl (R)-pyrrolidine-2-carboxylate (1.1 g, 98% yield) as a pale yellow solid.

References

[1] Patent: WO2018/20004, 2018, A1. Location in patent: Page/Page column 57
[2] Patent: WO2016/89977, 2016, A1. Location in patent: Paragraph 00143
[3] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 16, p. 5616 - 5624
[4] Chemistry Letters, 1982, p. 745 - 748
[5] Journal of Agricultural and Food Chemistry, 1993, vol. 41, # 9, p. 1458 - 1461

methyl D-prolinate Preparation Products And Raw materials

Raw materials

Preparation Products

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methyl D-prolinate Suppliers

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  • methyl D-prolinate
  • Proline Impurity 1
  • 43041-12-9