ChemicalBook > CAS DataBase List > 4-Bromo-2,6-diaminopyridine

4-Bromo-2,6-diaminopyridine

Product Name
4-Bromo-2,6-diaminopyridine
CAS No.
329974-09-6
Chemical Name
4-Bromo-2,6-diaminopyridine
Synonyms
4-Bromo-2,6-diaminopyridine;4-Bromopyridine-2,6-diamine;2,6-Diamino-4-bromopyridine;4-bromo-2,6-Pyridinediamine;2,6-Pyridinediamine, 4-bromo-;4-Bromo-2,6-diaminopyridine ,98%;TIANFU CHEM-- 4-Bromo-2,6-diaminopyridine;methyl 2-amino-5-bromo-3,4-difluorobenzoate;4-Bromo-2,6-diaminopyridine ISO 9001：2015 REACH
CBNumber
CB6947079
Molecular Formula
C5H6BrN3
Formula Weight
188.03
MOL File
329974-09-6.mol
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4-Bromo-2,6-diaminopyridine Property

Melting point:
126 °C
Boiling point:
352.7±37.0 °C(Predicted)
Density 
1.818±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
powder
pka
5.13±0.35(Predicted)
color 
White
InChI
InChI=1S/C5H6BrN3/c6-3-1-4(7)9-5(8)2-3/h1-2H,(H4,7,8,9)
InChIKey
KXHPZYVKCDTIHE-UHFFFAOYSA-N
SMILES
C1(N)=NC(N)=CC(Br)=C1
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B683120
Product name
4-​Bromo-​2,​6-​diaminopyridine
Packaging
100mg
Price
$85
Updated
2021/12/16
TRC
Product number
B683120
Product name
4-​Bromo-​2,​6-​diaminopyridine
Packaging
5g
Price
$800
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0023236
Product name
4-BROMO-2,6-DIAMINOPYRIDINE
Purity
95.00%
Packaging
5G
Price
$1322.48
Updated
2021/12/16
Matrix Scientific
Product number
057391
Product name
4-Bromo-2,6-diaminopyridine
Purity
95%
Packaging
5g
Price
$620
Updated
2021/12/16
Apolloscientific
Product number
OR13619
Product name
4-Bromo-2,6-diaminopyridine
Packaging
5g
Price
$679
Updated
2021/12/16
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4-Bromo-2,6-diaminopyridine Chemical Properties,Usage,Production

Chemical Properties

Off-white solid

Uses

4-?Bromo-?2,?6-?diaminopyridine is a versatile reactant used in the preparation of a uracil DNA glycosylase which is a DNA repair enzyme with selective recognition of uracil and its derivatives.

Synthesis

1310-73-2

76-05-1

329974-10-9

329974-09-6

c) Synthesis of 4-bromo-2,6-diaminopyridine 1 g (3.65 mmol) of 4-bromo-pyridine-2,6-dicarboxylic acid dihydrazide was suspended in 32 mL of water and 1.6 mL of 37% HCl was added at room temperature.The reaction mixture was cooled down to 0 °C and 554 mg of NaNO2 dissolved in 2.4 mL of water was slowly added keeping the reaction temperature below 2 °C. The reaction temperature was adjusted to 8 °C by filtration. After completion of the reaction, the pH was adjusted to 8 with saturated NaHCO3 solution, the white precipitate was collected by filtration and washed with cold water. The solid residue was dissolved in CHCl3 and dried with MgSO4. The filtrate was concentrated at 20 °C to give 920 mg (85%) white solid. 450 mg (1.5 mmol) of the above white solid was suspended in a solvent mixture of toluene/tert-butanol (5:1) and refluxed for 12 hours. After removing the solvent under reduced pressure, 5 mL of toluene and 0.3 mL of trifluoroacetic acid were added and reflux was continued for 2 hours. The solvent was again removed under reduced pressure and the residue was purified by rapid chromatography on silica gel using dichloromethane/methanol (9:1) as eluent. After elution the solvent was removed under reduced pressure and the residue was suspended in diethyl ether and a 1N NaOH solution was added to release 4-bromo-2,6-diaminopyridine. The organic phase was dried over Na2SO4 and the solvent was removed under reduced pressure to give 192 mg (67%) of the target product. Mass spectrometry analysis showed m/e: 188 (M+, 100%).

References

[1] Patent: US6355653, 2002, B1. Location in patent: Page column 27-28

4-Bromo-2,6-diaminopyridine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide PHOSPHORUS PENTABROMIDE Ethanol N,N-Dimethylformamide Potassium hydroxide Acetone Diethyl oxalate Chloroform Sodium ethoxide Sodium nitrite Hydrochloric acid Bromine Potassium permanganate Methanol 2,6-DIMETHYL-PYRIDIN-4-YLAMINE Activated carbon Sulfuric acid

Preparation Products

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4-Bromo-2,6-diaminopyridine Suppliers

Canada 1 China 105 Europe 1 Germany 1 India 3 Switzerland 1 United Kingdom 5 United States 16 Global 133
Pure Chemistry Scientific Inc.
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View Lastest Price from 4-Bromo-2,6-diaminopyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-Bromo-2,6-diaminopyridine 329974-09-6
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-12
Career Henan Chemical Co
Product
4-Bromo-2,6-diaminopyridine 329974-09-6
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-22

329974-09-6, 4-Bromo-2,6-diaminopyridineRelated Search:

1-Hexadecylpyridinium bromide 2,6-Dibromopyridine HYDRAZINE 2-Aminopyridine 4-Bromo-2,5-dichloropyridine 4-BroMo-2,5-difluoropyridine 3-Aminopyridine 4-Bromopyridine 2,6-Lutidine 2,6-Diaminopyridine 4-Bromo-2,6-dimethylpyridine 4-Dimethylaminopyridine 1,3-Diaminoguanidine monohydrochloride 2-Amino-4-bromopyridine Bromine 3,4-diamino-5-bromopyridine 2,3-Diamino-5-bromopyridine 4-Bromo-2,6-diaminopyridine

  • 4-Bromo-2,6-diaminopyridine ,98%
  • 2,6-Diamino-4-bromopyridine
  • 4-Bromopyridine-2,6-diamine
  • 4-Bromo-2,6-diaminopyridine
  • methyl 2-amino-5-bromo-3,4-difluorobenzoate
  • 2,6-Pyridinediamine, 4-bromo-
  • 4-bromo-2,6-Pyridinediamine
  • 4-Bromo-2,6-diaminopyridine ISO 9001：2015 REACH
  • TIANFU CHEM-- 4-Bromo-2,6-diaminopyridine
  • 329974-09-6