Rutaecarpine
- Product Name
- Rutaecarpine
- CAS No.
- 20575-76-2
- Chemical Name
- Rutaecarpine
- Synonyms
- Ai3-51108;Nsc 255317;Brn 2116874;Rutaecarpine;3,3'-HEXAMETHYLENEBIS(1,1-DIMETHYLUREA);1,1'-Hexamethylenebis[3,3-dimethylurea];Urea, 1,1'-hexamethylenebis(3,3-dimethyl-;1,1-(Hexane-1,6-diyl)bis(3,3-dimethylurea);N,N''-1,6-Hexanediylbis[N',N'-dimethylurea];1,1'-(Hexane-1,6-diyl)bis(3,3-dimethylurea)
- CBNumber
- CB6975933
- Molecular Formula
- C12H26N4O2
- Formula Weight
- 258.36
- MOL File
- 20575-76-2.mol
Rutaecarpine Property
- Boiling point:
- 512.3±33.0 °C(Predicted)
- Density
- 1.021±0.06 g/cm3(Predicted)
- pka
- 13.98±0.46(Predicted)
N-Bromosuccinimide Price
- Product number
- S590355
- Product name
- 3,3'-HEXAMETHYLENEBIS(1,1-DIMETHYLUREA)
- Purity
- Aldrich
- Packaging
- 250mg
- Price
- $29.8
- Updated
- 2024/03/01
Rutaecarpine Chemical Properties,Usage,Production
Biological Functions
Rutaecarpine also inhibits accumulation of macrophages and cholesterol in atherosclerotic lesions and increases cholesterol excretion in other animal models. Additionally, rutaecarpine inhibits hypoxia-induced production of ROS and lactate dehydrogenase and suppresses apoptosis in myocardiocytes. In other cellular models, rutaecarpine decreases corticosterone production, potentially through inhibition of cAMP, 3β-hydroxysteroid dehydrogenase, and 11β-hydroxylase activity.
Biological Activity
Rutaecarpine is an indoloquinazoline alkaloid originally found in Evodia; it exhibits anti-inflammatory, anti-atherosclerotic, cardioprotective, anorexigenic, and anti-obesity activities. Rutaecarpine inhibits COX-2 and also decreases food intake, weight gain, and serum glucose, leptin, and insulin levels in vivo by inhibiting expression of neuropeptide Y and AgRP.
Mechanism of action
Rutaecarpine also inhibits production of ROS, NO, and iNOS, potentially through inhibition of NADPH oxidase. In macrophages, rutaecarpine inhibits arachidonic acid release and decreases production of prostaglandin E2 (PGE2); in other in vitro models, it inhibits collagen-stimulated formation of thromboxane B2 and inosine monophosphate.
Rutaecarpine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Rutaecarpine manufacturers
- Product
- Rutaecarpine 20575-76-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons
- Release date
- 2020-02-03