2-Hydroxychalcone
- Product Name
- 2-Hydroxychalcone
- CAS No.
- 644-78-0
- Chemical Name
- 2-Hydroxychalcone
- Synonyms
- 2-HYDROXYCHALCONE;o-Hydroxychalcone;2-HYDROXYCHALCONE;HYDROXYCHALCONE, 2-;2-Hydroxychalcone>SALICYLALACETOPHENONE;2-Hydroxychalcone, 98+%;TRANS-2-HYDROXYCHALCONE;2-(2-HYDROXYBENZAL)ACETOPHENONE;2-HYDROXYBENZYLIDENE ACETOPHENONE
- CBNumber
- CB7100356
- Molecular Formula
- C15H12O2
- Formula Weight
- 224.25
- MOL File
- 644-78-0.mol
2-Hydroxychalcone Property
- Melting point:
- 144-150 °C(lit.)
- Boiling point:
- 396.3±34.0 °C(Predicted)
- Density
- 1.191±0.06 g/cm3(Predicted)
- pka
- 9.26±0.35(Predicted)
- form
- powder
- color
- Yellow
- BRN
- 2049134
- CAS DataBase Reference
- 644-78-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- S218170
- Product name
- 3-(2-HYDROXY-PHENYL)-1-PHENYL-PROPENONE
- Purity
- AldrichCPR
- Packaging
- 25MG
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- H0234
- Product name
- 2-Hydroxychalcone
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $54
- Updated
- 2021/12/16
- Product number
- H0234
- Product name
- 2-Hydroxychalcone
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $148
- Updated
- 2021/12/16
- Product number
- A12851
- Product name
- 2-Hydroxychalcone, 98+%
- Packaging
- 5g
- Price
- $34.65
- Updated
- 2024/03/01
- Product number
- A12851
- Product name
- 2-Hydroxychalcone, 98+%
- Packaging
- 25g
- Price
- $126.65
- Updated
- 2024/03/01
2-Hydroxychalcone Chemical Properties,Usage,Production
Description
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. It is also capable of inducing apoptosis by downregulating Bcl-2 levels and inhibiting the activation of NF-kB.
Synthesis
A synthesis of 2-Hydroxychalcone was conducted using acetophenone and o-hydroxybenzaldehyde as starting materials. The reaction was catalyzed by potassium hydroxide and ethanol was used as the solvent.
in vitro
2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells.
2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner.
References
[1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72. DOI:10.1016/j.cbi.2013.03.012
[2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34. DOI:10.1124/MOL.58.3.526
[3]. Sonochemical Synthesis of 2’-Hydroxy-Chalcone Derivatives with Potential Anti-Oomycete Activity doi: 10.3390/antibiotics9090576
2-Hydroxychalcone Preparation Products And Raw materials
Raw materials
Preparation Products
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