2-Hydroxychalcone

ChemicalBook > CAS DataBase List > 2-Hydroxychalcone

2-Hydroxychalcone

Product Name: 2-Hydroxychalcone
CAS No.: 644-78-0
Chemical Name: 2-Hydroxychalcone
Synonyms: o-Hydroxychalcone;2-HYDROXYCHALCONE;HYDROXYCHALCONE, 2-;2-Hydroxychalcone>SALICYLALACETOPHENONE;HYDROXYCHALCONE,2-(AS);TRANS-2-HYDROXYCHALCONE;2-Hydroxychalcone, 98+%;2-(2-HYDROXYBENZAL)ACETOPHENONE;2-Hydroxychalcone, 10 mM in DMSO
CBNumber: CB7100356
Molecular Formula: C15H12O2
Formula Weight: 224.25
MOL File: 644-78-0.mol

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2-Hydroxychalcone Property

Melting point:: 144-150 °C(lit.)
Boiling point:: 396.3±34.0 °C(Predicted)
Density: 1.191±0.06 g/cm3(Predicted)
pka: 9.26±0.35(Predicted)
form: powder
color: Yellow
BRN: 2049134
CAS DataBase Reference: 644-78-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S218170
Product name: 3-(2-HYDROXY-PHENYL)-1-PHENYL-PROPENONE
Purity: AldrichCPR
Packaging: 25MG
Price: $29.8
Updated: 2024/03/01

TCI Chemical

Product number: H0234
Product name: 2-Hydroxychalcone
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $54
Updated: 2021/12/16

TCI Chemical

Product number: H0234
Product name: 2-Hydroxychalcone
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $148
Updated: 2021/12/16

Alfa Aesar

Product number: A12851
Product name: 2-Hydroxychalcone, 98+%
Packaging: 5g
Price: $34.65
Updated: 2024/03/01

Alfa Aesar

Product number: A12851
Product name: 2-Hydroxychalcone, 98+%
Packaging: 25g
Price: $126.65
Updated: 2024/03/01

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2-Hydroxychalcone Chemical Properties,Usage,Production

Description

2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. It is also capable of inducing apoptosis by downregulating Bcl-2 levels and inhibiting the activation of NF-kB.

Synthesis

A synthesis of 2-Hydroxychalcone was conducted using acetophenone and o-hydroxybenzaldehyde as starting materials. The reaction was catalyzed by potassium hydroxide and ethanol was used as the solvent.

in vitro

2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells.
2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner.

References

[1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72. DOI:10.1016/j.cbi.2013.03.012
[2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34. DOI:10.1124/MOL.58.3.526
[3]. Sonochemical Synthesis of 2’-Hydroxy-Chalcone Derivatives with Potential Anti-Oomycete Activity doi: 10.3390/antibiotics9090576

2-Hydroxychalcone Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Hydroxychalcone Suppliers

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644-78-0, 2-HydroxychalconeRelated Search:

HYDROXYCHALCONE, 4-,4-HYDROXYCHALCONE HYDROXYCHALCONE, 2-,TRANS-2-HYDROXYCHALCONE 2'-Hydroxychalcone DIMETHOXY-2'-HYDROXYCHALCONE, 2,3-,2,3-DIMETHOXY-2'-HYDROXYCHALCONE 4'-HYDROXYCHALCONE,HYDROXYCHALCONE, 4'- trans-Chalcone 4',6'-DIMETHOXY-2'-HYDROXYCHALCONE,DIMETHOXY-2'-HYDROXYCHALCONE, 4',6'- 5'-CHLORO-3,4-DIMETHOXY-2'-HYDROXYCHALCONE (E)-2'-hydroxychalcone 4',6'-DIMETHOXY-4-FLUORO-2'-HYDROXYCHALCONE 5'-BROMO-4-CHLORO-2'-HYDROXYCHALCONE 5'-BROMO-3,4-DIMETHOXY-2'-HYDROXYCHALCONE 4-BUTYL-4'-HYDROXYCHALCONE 4'-FLUORO-2-HYDROXYCHALCONE 4-CHLORO-5'-FLUORO-2'-HYDROXYCHALCONE 4-CHLORO-2'-HYDROXYCHALCONE 4-CHLORO-4',6'-DIMETHOXY-2'-HYDROXYCHALCONE 4',6'-DIMETHOXY-4-DIMETHYLAMINO-2'-HYDROXYCHALCONE

BENZYLIDENE-2-HYDROXYACETOPHENONE

(E)-3-(2-HYDROXYPHENYL)-1-PHENYLPROP-2-EN-1-ONE

HYDROXYCHALCONE, 2-

2-HYDROXYBENZYLIDENE ACETOPHENONE

2-(2-HYDROXYBENZAL)ACETOPHENONE

2-(2-HYDROXYBENZYLIDENE)ACETOPHENONE

(2-Hydroxybenzylidene)acetophenone~3-(2-Hydroxyphenyl)-1-phenyl-2-propen-1-one

2-Hydroxychalcone, 98+%

SALICYLALACETOPHENONE

TRANS-2-HYDROXYBENZYLIDENEACETOPHENONE

TRANS-2-HYDROXYCHALCONE

3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one

o-Hydroxychalcone

α-(o-Hydroxybenzylidene)acetophenone

2-(2-Hydroxybenzal)acetophenone 2-(2-Hydroxybenzylidene)acetophenone Salicylalacetophenone

3-(2-hydroxyphenyl)-1-phenyl-2-propen-1-one

2-HYDROXYCHALCONE(UNSPECIFIEDISOMER)

2-Hydroxychalcone&gt

2-Propen-1-one, 3-(2-hydroxyphenyl)-1-phenyl-

2-HYDROXYCHALCONE

inhibit,Inhibitor,Apoptosis,Nuclear factor-κB,Nuclear factor-kappaB,NF-κB,TNBC,2 Hydroxychalcone,2-Hydroxychalcone,Bcl-2 Family,2Hydroxychalcone

HYDROXYCHALCONE,2-(AS)

2-Hydroxychalcone, 10 mM in DMSO

3-(2-HYDROXY-PHENYL)-1-PHENYL-PROPENONE

644-78-0

Ketones

Organic Building Blocks

Carbonyl Compounds

C15 to C38

Building Blocks

Chalcones, etc. (Building Blocks for Liquid Crystals)

Flavonoids

Building Blocks for Liquid Crystals

Biochemistry

Building Blocks for Liquid Crystals

Chalcones, etc. (Building Blocks for Liquid Crystals)

Flavonoids

Functional Materials

Chalcones