ChemicalBook > CAS DataBase List > Tak-715

Tak-715

Product Name: Tak-715
CAS No.: 303162-79-0
Chemical Name: Tak-715
Synonyms: Tak-715;CS-1566;TAK-715; TAK715;TAK-715, 10 mM in DMSO;TAK 715, p38 MAPK inhibitor;Tak-715 ISO 9001：2015 REACH;N-(4-(2-Ethyl-4-(m-tolyl)thiazol-5-yl)pyridin-2-yl)benzamide;N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide;N-(4-(2-Ethyl-4-(3-methylphenyl)-thiazol-5-yl)pyridin-2-yl)benzamide;N-(4-(2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide
CBNumber: CB71017172
Molecular Formula: C24H21N3OS
Formula Weight: 399.51
MOL File: 303162-79-0.mol

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Tak-715 Property

storage temp.: Sealed in dry,2-8°C
solubility: DMSO: >15mg/mL
form: powder
color: faint yellow to dark yellow
InChI: InChI=1S/C24H21N3OS/c1-3-21-27-22(18-11-7-8-16(2)14-18)23(29-21)19-12-13-25-20(15-19)26-24(28)17-9-5-4-6-10-17/h4-15H,3H2,1-2H3,(H,25,26,28)
InChIKey: HEKAIDKUDLCBRU-UHFFFAOYSA-N
SMILES: C(NC1=NC=CC(C2SC(CC)=NC=2C2=CC=CC(C)=C2)=C1)(=O)C1=CC=CC=C1

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 3
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0360
Product name: TAK-715
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $197
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0360
Product name: TAK-715
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $674
Updated: 2022/05/15

Cayman Chemical

Product number: 26170
Product name: TAK-715
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 26170
Product name: TAK-715
Packaging: 50mg
Price: $632
Updated: 2024/03/01

Cayman Chemical

Product number: 26170
Product name: TAK-715
Packaging: 10mg
Price: $152
Updated: 2024/03/01

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Tak-715 Chemical Properties,Usage,Production

Uses

TAK 715 is a p38 MAPK inhibitor for p38α and p38β but not for p38γ and p38δ.

Definition

ChEBI: N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide is a member of benzamides.

Biological Activity

tak-715 is a selective inhibitor of p38 mapk with ic50 value of 7.1 nm [1].p38 mitogen-activated protein (map) kinases (p38 mapks) are a class of mitogen-activated protein kinases and play an important role in controlling cellular responses to cytokines and stress. four p38 mapks contain members, p38-α (mapk14), p38-β (mapk11), p38-γ (mapk12/erk6), and p38-δ (mapk13/sapk4), have been identified. abnormal expression of p38 mapks are correlated with a variety of chronic inflammatory diseases and their inhibitors are regarded as promising targets in clinical [1] [2].tak-715 is a potent p38 mapk inhibitor and has a different selectivity with the reported p38 mapk inhibitor vx-745. when tested with human monocytic thp-1 cells, administration of tak-715 exhibited inhibition on p38mapkα with ic50 value of 7.1 nm [1]. in hek293t, u2os, and f9 cells, tak-715 was used to inhibit p38 mapk activity and concluded that p38 mapk had no function in wnt/β-catenin signaling pathway [2].in adjuvant-induced rheumatoid arthritis rat model, administration of tak-715 at dose of 10 mg/kg significantly decreased lps-induced stimulated release of tnf-α (87.6%) by inhibiting p38 mapk activity [1].

in vivo

TAK-715 (compound 8h; 3-30 mg/kg; PO) significantly reduces the secondary paw volume^[1].
TAK-715 (10 mg/kg; PO) has a C_max of 0.19 μg/mL and an AUC of 1.16 μg h/mL.

Animal Model:	7-week-old male Lewis rats with arthritis^[1]
Dosage:	3, 10, 30 mg/kg
Administration:	PO; single dose
Result:	Significantly reduced the secondary paw volume (25% inhibition)

Animal Model:	Rat^[1]
Dosage:	10 mg/kg (Pharmacokinetic Analysis)
Administration:	PO
Result:	Had a C_max of 0.19 μg/mL and an AUC of 1.16 μg?h/mL.

IC 50

p38α: 7.1 nM (IC₅₀); p38β: 200 nM (IC₅₀); p38δ: >10 μM (IC₅₀); p38γ: >10 μM (IC₅₀); CK1δ; CK1ε

storage

+4°C

References

[1]. miwatashi, s., et al., novel inhibitor of p38 map kinase as an anti-tnf-alpha drug: discovery of n-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (tak-715) as a potent and orally active anti-rheumatoid arthritis agent. j med chem, 2005. 48(19): p. 5966-79.
[2]. verkaar, f., et al., inhibition of wnt/beta-catenin signaling by p38 map kinase inhibitors is explained by cross-reactivity with casein kinase idelta/varepsilon. chem biol, 2011. 18(4): p. 485-94.

Tak-715 Preparation Products And Raw materials

Raw materials

Preparation Products

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Tak-715 Suppliers

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View Lastest Price from Tak-715 manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Tak-715 303162-79-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-04-30

Career Henan Chemical Co

Product: Tak-715 303162-79-0
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-12

303162-79-0, Tak-715Related Search:

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Tak-715

N-(4-(2-Ethyl-4-(3-methylphenyl)-thiazol-5-yl)pyridin-2-yl)benzamide

BenzaMide, N-[4-[2-ethyl-4-(3-Methylphenyl)-5-thiazolyl]-2-pyridinyl]-

N-(4-(2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide

N-(4-(2-Ethyl-4-(m-tolyl)thiazol-5-yl)pyridin-2-yl)benzamide

N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide

TAK-715; TAK715

CS-1566

N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-yl]benzamide

Tak-715 ISO 9001：2015 REACH

TAK 715, p38 MAPK inhibitor

TAK-715, 10 mM in DMSO

303162-79-0

Inhibitors

MAPK