Tak-715
- Product Name
- Tak-715
- CAS No.
- 303162-79-0
- Chemical Name
- Tak-715
- Synonyms
- Tak-715;CS-1566;TAK-715; TAK715;Tak-715 ISO 9001：2015 REACH;N-(4-(2-Ethyl-4-(m-tolyl)thiazol-5-yl)pyridin-2-yl)benzamide;N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide;N-(4-(2-Ethyl-4-(3-methylphenyl)-thiazol-5-yl)pyridin-2-yl)benzamide;N-(4-(2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide;BenzaMide, N-[4-[2-ethyl-4-(3-Methylphenyl)-5-thiazolyl]-2-pyridinyl]-;N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-yl]benzamide
- CBNumber
- CB71017172
- Molecular Formula
- C24H21N3OS
- Formula Weight
- 399.51
- MOL File
- 303162-79-0.mol
Tak-715 Property
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: >15mg/mL
- form
- powder
- color
- faint yellow to dark yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML0360
- Product name
- TAK-715
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $192
- Updated
- 2024/03/01
- Product number
- SML0360
- Product name
- TAK-715
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $674
- Updated
- 2022/05/15
- Product number
- 26170
- Product name
- TAK-715
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 26170
- Product name
- TAK-715
- Packaging
- 50mg
- Price
- $632
- Updated
- 2024/03/01
- Product number
- 26170
- Product name
- TAK-715
- Packaging
- 10mg
- Price
- $152
- Updated
- 2024/03/01
Tak-715 Chemical Properties,Usage,Production
Uses
TAK 715 is a p38 MAPK inhibitor for p38α and p38β but not for p38γ and p38δ.
Definition
ChEBI: N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide is a member of benzamides.
Biological Activity
tak-715 is a selective inhibitor of p38 mapk with ic50 value of 7.1 nm [1].p38 mitogen-activated protein (map) kinases (p38 mapks) are a class of mitogen-activated protein kinases and play an important role in controlling cellular responses to cytokines and stress. four p38 mapks contain members, p38-α (mapk14), p38-β (mapk11), p38-γ (mapk12/erk6), and p38-δ (mapk13/sapk4), have been identified. abnormal expression of p38 mapks are correlated with a variety of chronic inflammatory diseases and their inhibitors are regarded as promising targets in clinical [1] [2].tak-715 is a potent p38 mapk inhibitor and has a different selectivity with the reported p38 mapk inhibitor vx-745. when tested with human monocytic thp-1 cells, administration of tak-715 exhibited inhibition on p38mapkα with ic50 value of 7.1 nm [1]. in hek293t, u2os, and f9 cells, tak-715 was used to inhibit p38 mapk activity and concluded that p38 mapk had no function in wnt/β-catenin signaling pathway [2].in adjuvant-induced rheumatoid arthritis rat model, administration of tak-715 at dose of 10 mg/kg significantly decreased lps-induced stimulated release of tnf-α (87.6%) by inhibiting p38 mapk activity [1].
storage
+4°C
References
[1]. miwatashi, s., et al., novel inhibitor of p38 map kinase as an anti-tnf-alpha drug: discovery of n-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (tak-715) as a potent and orally active anti-rheumatoid arthritis agent. j med chem, 2005. 48(19): p. 5966-79.
[2]. verkaar, f., et al., inhibition of wnt/beta-catenin signaling by p38 map kinase inhibitors is explained by cross-reactivity with casein kinase idelta/varepsilon. chem biol, 2011. 18(4): p. 485-94.
Tak-715 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Tak-715 manufacturers
- Product
- Tak-715 303162-79-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-04-30
- Product
- Tak-715 303162-79-0
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12