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MECLOFENAMATE SODIUM

Product Name
MECLOFENAMATE SODIUM
CAS No.
6385-02-0
Chemical Name
MECLOFENAMATE SODIUM
Synonyms
ci583;C02996;Movens;meclomen;Meclonax;Meclofenamate;SODIUM MECLOFENAMATE;sodiummeclophenamate;MECLOFENAMATE SODIUM;MECLOFENAMATESODIUM,USP
CBNumber
CB7102365
Molecular Formula
C14H10Cl2NO2.Na
Formula Weight
318.13
MOL File
6385-02-0.mol
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MECLOFENAMATE SODIUM Property

Melting point:
287-291 °C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
White solid.
color 
White to Off-White
biological source
synthetic (organic)
Water Solubility 
Soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol
Merck 
14,5779
Stability:
Hygroscopic
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Safety

WGK Germany 
3
RTECS 
CB2975500
HS Code 
2922498050
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M4531
Product name
Meclofenamic acid sodium salt
Packaging
1g
Price
$56.6
Updated
2024/03/01
Sigma-Aldrich
Product number
1377803
Product name
Meclofenamate Sodium
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$467
Updated
2024/03/01
TCI Chemical
Product number
M1269
Product name
Sodium Meclofenamate
Packaging
1G
Price
$63
Updated
2024/03/01
TCI Chemical
Product number
M1269
Product name
Sodium Meclofenamate Hydrate
Purity
>98.0%(HPLC)(N)
Packaging
10g
Price
$372
Updated
2024/03/01
Alfa Aesar
Product number
J60484
Product name
Meclofenamic acid sodium salt, 99+%
Packaging
1g
Price
$43.65
Updated
2024/03/01
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MECLOFENAMATE SODIUM Chemical Properties,Usage,Production

Description

Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC50 values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 μM, respectively for instantaneous inhibition. However, the IC50 is much lower if pre-incubated with the enzyme.

Originator

Meclomen,Warner Lambert,US,1980

Uses

antiinflammatory, antipyretic

Uses

Meclofenamate Sodium is an NSAID used in the treatment of chronic pain.

Indications

Meclofenamate sodium (Meclomen) is prescribed for rheumatoid arthritis and osteoarthritis. The fenamates show no clear superiority in antiinflammatory activity and may produce more adverse effects than other NSAIDs.

Definition

ChEBI: An organic sodium salt derived from meclofenamic acid. Its monohydrate is used for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.

Manufacturing Process

A mixture consisting of 22.7 g potassium o-bromobenzoate, 16.6 g 2,6- dichloro-3-methylaniline, 12 ml N-ethylmorpholine, 60 ml diethylene glycol dimethyl ether, and 1.0 g anhydrous cupric bromide is heated in a nitrogen atmosphere at 145°C to 155°C for 2 hours. The reaction mixture is diluted with 60 ml diethylene glycol dimethyl ether and acidified with 25 ml concentrated hydrochloric acid. The acidic mixture is diluted with 100 ml of water and the liquid phase decanted from the insoluble oil. The insoluble oil is stirred with methanol and the crystalline N-(2,6-dichloro-3-methylphenyl) anthranilic acid which separates is collected and washed with methanol. The product, after recrystallization from acetone-water mixture, melts at 248°C to 250°C.

brand name

Meclomen (Parke-Davis).

Therapeutic Function

Antiinflammatory

General Description

Meclofenamate sodium (Meclomen) is available for use inthe treatment of acute and chronic RA, OA, and primarydysmenorrhea. It is metabolized in a similar manner tomefenamic acid discussed above, thus a similar restriction isalso applied to meclofenamate. The most significant side effectsare GI, including diarrhea.

Pharmacokinetics

Meclofenamate sodium is rapidly and almost completely absorbed following oral administration, reaching peak plasma levels within 2 hours. It is highly bound to plasma proteins (99%) and has a plasma half-life of 2 to 4 hours. Metabolism involves oxidation of the methyl group, aromatic hydroxylation, monodehalogenation, and conjugation. Urinary excretion accounts for approximately 75% of the administered dose. The major metabolite is the product of 3′-methyl oxidation and has been shown to possess anti-inflammatory activity.

Clinical Use

Meclofenamate sodium is indicated for the relief of mild to moderate pain, the acute and chronic treatment of rheumatoid arthritis and osteoarthritis, the treatment of primary dysmenorrhea, and the treatment of idiopathic, heavy menstrual blood loss.

MECLOFENAMATE SODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

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MECLOFENAMATE SODIUM Suppliers

Americas 1 Belgium 1 China 69 Europe 1 Germany 4 India 7 Japan 1 Poland 1 Slovakia 1 Switzerland 1 United Kingdom 5 United States 32 Global 124
LGM Pharma
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View Lastest Price from MECLOFENAMATE SODIUM manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
Meclofenamic acid sodium salt 6385-02-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10000kg
Release date
2024-11-09
Dideu Industries Group Limited
Product
MECLOFENAMATE SODIUM 6385-02-0
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-15

6385-02-0, MECLOFENAMATE SODIUMRelated Search:

MCPA SODIUM CLOFENAMIC ACID SODIUM ANTHRANILATE Meclofenamic acid MECLOFENAMATE SODIUM N-Phenylanthranilic acid 2,6-DICHLORODIPHENYLAMINE 2-Chloro-5-methylaniline 2,6-Dichloro-3-methylaniline 2-Chloro-m-toluidine. N-(2-CHLOROPHENYL)ANTHRANILIC ACID N-(3-METHYLPHENYL)ANTHRANILIC ACID 2-[(2-Chlorophenyl)amino]-benzaldehyde 2-[(2,6-dichlorophenyl)amino]benzoicacid (2-CHLORO-PHENYL)-PHENYL-AMINE (2-(2,6-DICHLOROANILINO)PHENYL) METHANOL 2-(2,6-Dichloroanilino) benzaldehyde MECLOFENAMATE SODIUM USP(CRM STANDARD)

  • MECLOFENAMIC ACID SODIUM SALT MONOHYDRATE
  • Sodium Meclofenamate Monohydrate
  • C02996
  • sodium 2-(2,6-dichloro-3-methylanilino)benzoate hydrate
  • SODIUM MECLOFENAMATE
  • meclofenamic acid sodium
  • MECLOFENAMIC ACID SODIUM SALT 99%
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  • sodium meclofenamate (anhydrous)
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  • sodiummeclophenamate
  • MECLOFENAMATE SODIUM
  • MECLOFENAMATE SODIUM HYDRATE
  • MECLOFENAMATE SODIUM SALT
  • MECLOFENAMIC ACID SODIUM SALT
  • 2-[(2,6-DICHLORO-3-METHYLPHENYL)AMINO]-BENZOIC ACID, MONOSODIUM SALT
  • 2-[(2,6-DICHLORO-3-METHYLPHENYL)AMINO]BENZOIC ACID SODIUM SALT
  • sodium,2-(2,6-dichloro-3-methylanilino)benzoate
  • 2-((2,6-dichloro-3-methylphenyl)amino)-benzoicacimonosodiumsalt
  • ci583
  • meclomen
  • n-(2,6-dichloro-m-tolyl)-anthranilicacimonosodiumsalt
  • Benzoic acid, 2-[(2,6-dichloro-3-Methylphenyl)aMino]-, sodiuM salt
  • Meclofenamate Sodium (500 mg)
  • 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic Acid Sodium Salt Meclofenamic Acid Sodium Salt
  • SodiuM MeclofenaMate&nbsp
  • Benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-, sodium salt (1:1)
  • 2-[(2,6-dichloro-3-methylphenyl)amino]-benzoic acid, sodium salt (1:1)
  • Sodium Meclofenamate Hydrate
  • SodiumMeclofenamateMonohydrate&gt
  • Meclonax
  • Movens
  • 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt monohydrate
  • MECLOFENAMATE SODIUM USP/EP/BP
  • Meclofenamate Sodium (Meclofenamic acid sodium)
  • Meclofenamate Sodium (1377803)
  • Endogenous Metabolite,Meclofenamate,Inhibitor,Meclofenamic acid sodium,inhibit,Meclofenamic acid,Gap Junction Protein
  • Sodium Meclofenamate Monohydrate, ≥ 98.0%
  • Meclofenamic acid sodium, 10 mM in DMSO
  • 6385-02-0
  • 6358-02-0
  • C14H10Cl2NO2NaH2O
  • C14H10Cl2NNaO2xH2O
  • C14H11Cl2NNaO2
  • C14H10Cl2NNaO2H2O
  • Lipoxygenase (5-) and cyclooxygenase
  • L to O
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • BioChemical
  • Biochemicals and Reagents
  • MECLOMEN