(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride
- Product Name
- (Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride
- CAS No.
- 117857-45-1
- Chemical Name
- (Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride
- Synonyms
- R-72063;Loreclezole;LoreclezoleHCl;Loreclezole, 10 mM in DMSO;1-[(Z)-2-chloro-2-(2,4-dichlorophenyl)ethenyl]-1,2,4-triazole;(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)vinyl)-1H-1,2,4-triazole;1-[(Z)-2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole;1H-1,2,4-Triazole, 1-[(1Z)-2-chloro-2-(2,4-dichlorophenyl)ethenyl]-;(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)vinyl)-1H-1,2,4-triazole hydrochloride;γ-Aminobutyric acid Receptor,R 72063,Inhibitor,GABA Receptor,Loreclezole,Gamma-aminobutyric acid Receptor,R72063,R-72063,inhibit
- CBNumber
- CB71075257
- Molecular Formula
- C10H6Cl3N3
- Formula Weight
- 274.53
- MOL File
- 117857-45-1.mol
(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride Property
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- <1.37mg/ml in DMSO; <1.37mg/ml in ethanol
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- JN0002
- Product name
- Loreclezole
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $95
- Updated
- 2025/07/31
- Product number
- JN0002
- Product name
- Loreclezole
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $406
- Updated
- 2025/07/31
- Product number
- CS-0025565
- Product name
- Loreclezole
- Purity
- 99.81%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-0025565
- Product name
- Loreclezole
- Purity
- 99.81%
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- B6676
- Product name
- Loreclezolehydrochloride
- Packaging
- 5mg
- Price
- $189
- Updated
- 2021/12/16
(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride Chemical Properties,Usage,Production
Uses
Anti-epileptic.
Definition
ChEBI: 1-[2-chloro-2-(2,4-dichlorophenyl)ethenyl]-1,2,4-triazole is a dichlorobenzene.
Biological Activity
Subtype-selective GABA A receptor modulator. Acts as a positive allosteric modulator of β 2 or β 3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABA A receptor sensitization. Inhibits homomeric ρ 1 GABA C receptors.
in vivo
Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the "pull-up" test[3].
| Animal Model: | Adult male Lister Hooded rats[3]. |
| Dosage: | 10, 25, 50 or 75 mg/kg. |
| Administration: | IP, 60 min before measurement of seizure threshold. |
| Result: | Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. |
(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride Suppliers
- Tel
- --
- Fax
- --
- labchem-tec@wako-chem.co.jp
- Country
- Japan
- ProdList
- 6819
- Advantage
- 80