Netilmicin sulfate

Product Name: Netilmicin sulfate
CAS No.: 56391-57-2
Chemical Name: Netilmicin sulfate
Synonyms: netromycin;Netromicine;NETILMYCIN SULFATE;Netililn;Zetamicin;Sulfate NetilMicin;sulfate(2:5)(salt);Netromycin sulfate;1-N-ETHYLSISOMICIN;NETILMICIN SULFATE
CBNumber: CB7121612
Molecular Formula: C42H92N10O34S5
Formula Weight: 1441.55
MOL File: 56391-57-2.mol

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Netilmicin sulfate Property

Melting point:: >194°C (dec.)
Boiling point:: 868℃
storage temp.: Inert atmosphere,2-8°C
solubility: H2O: soluble10mg/mL
form: Solid
color: white to faint yellow
Water Solubility: Soluble in water
Sensitive: Light Sensitive & Hygroscopic
Stability:: Hygroscopic
EPA Substance Registry System: Netilmicin sulfate (56391-57-2)

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Safety

Hazard Codes: T,Xi
Risk Statements: 61-20/21/22-60
Safety Statements: 53-36/37/39-45-37/39-36-26
WGK Germany: 3
RTECS: WK2286000
HS Code: 2941906000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001890
Product name: Netilmicin for peak identification
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: Y0001890
Price: $150
Updated: 2024/03/01

Sigma-Aldrich

Product number: N0755
Product name: Netilmicin sulfate salt
Packaging: 5mg
Price: $301.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1460500
Product name: Netilmicin sulfate
Packaging: 500mg
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: N1108
Product name: Netilmicin Sulfate
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $16
Updated: 2024/03/01

TCI Chemical

Product number: N1108
Product name: Netilmicin Sulfate
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $48
Updated: 2024/03/01

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Netilmicin sulfate Chemical Properties,Usage,Production

Description

Netilmicin Sulfate is the sulfate salt form of netilimicin, a member of the aminoglycoside family of antibiotics. Netilmicin is derived from sisomicin, a naturally occurring aminoglycoside antibiotic produced by the fermentation of Micromonospora inyoensis. It is an active aminoglycoside antibiotic against most Gram-negative and some Gram-positive bacteria, including certain strains resistant to gentamicin.

Chemical Properties

Off-White to Pale Beige Solid

Uses

Netilmicin sulfate is used as a broad spectrum antibiotic active against most Gram-negative and some Gram-positive bacteria. It is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but has less ear and kidney toxicity. It is used to treat gram-negative bacterial infections, gonorrhea, skin infections, and other infectious diseases. Since netilmicin sulfate cannot be absorbed from the gut, it can only be administered by injection.

Definition

ChEBI: Netilmicin sulfate is an aminoglycoside sulfate salt. It is functionally related to a netilmycin.

Application

Netilmicin was synthesized by ScheringPlough Co. in 1976. The ethyl moiety was introduced at the 1-amino group of sisomicin. Its design was based on an understanding of the biochemical mechanisms of bacterial resistance to the gentamicin – sisomicin antibiotic group. The modification at the 1-amino group is known to prevent adenylation at the 2- hydroxyl group and acetylation at the 3-amino group, and to deter acetylation at the 6 -amino residue. Netilmicin shows almost the same activity against a variety of gram-positive and gram-negative bacteria as sisomicin and strong activity against gentamicin – sisomicin-resistant bacteria. It is now under study for evaluation of its clinical efficacy and safety.

Clinical Use

Netilmicin sulfate, 1-N-ethylsisomicin (Netromycin), is asemisynthetic derivative prepared by reductive ethylation138of sisomicin, an aminoglycoside antibiotic obtained fromMicromonospora inyoensis. Structurally, sisomicin andnetilmicin resemble gentamicin Cla, a component of the gentamicincomplex.
Against most strains of Enterobacteriaceae, P. aeruginosa,and S. aureus, sisomicin and netilmicin are comparableto gentamicin in potency. Netilmicin is active, however,against many gentamicin-resistant strains, in particularamong E. coli, Enterobacter, Klebsiella, and Citrobacterspp. A few strains of gentamicin-resistant P. aeruginosa, S.marcescens, and indole-positive Proteus spp. are also sensitiveto netilmicin. Very few gentamicin-resistant bacterialstrains are sensitive to sisomicin, however. The potency ofnetilmicin against certain gentamicin-resistant bacteria is attributedto its resistance to inactivation by bacterial enzymesthat adenylylate or phosphorylate gentamicin and sisomicin.Evidently, the introduction of a 1-ethyl group in sisomicinmarkedly decreases the affinity of these enzymes forthe molecule in a manner similar to that observed in the1-N-ε-amino-α-hydroxybutyryl amide of kanamycin A(amikacin). Netilmicin, however, is inactivated by most of the bacterial enzymes that acetylate aminoglycosides,whereas amikacin is resistant to most of these enzymes.
The pharmacokinetic and toxicological properties ofnetilmicin and gentamicin appear to be similar clinically,though animal studies have indicated greater nephrotoxicityfor gentamicin.

Netilmicin sulfate Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Copper(II) acetate Ethanol Cupric acetate monohydrate

Preparation Products

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Netilmicin sulfate Suppliers

Americas 1 Canada 1 China 200 Europe 2 France 1 Germany 3 India 7 Japan 2 Switzerland 2 United Kingdom 12 United States 30 Global 261

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

Wako Pure Chemical Industries, Ltd.

Tel: --
Fax: --
Email: labchem-tec@wako-chem.co.jp
Country: Japan
ProdList: 6819
Advantage: 80

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View Lastest Price from Netilmicin sulfate manufacturers

Qiuxian Baitai New Material Co., LTD

Product: Netilmicin sulfate 56391-57-2
Price: US $80.00/KG
Min. Order: 10g
Purity: 99%
Supply Ability: 500ton/Month
Release date: 2021-11-05

Zhuozhou Wenxi import and Export Co., Ltd

Product: Netilmicin sulfate 56391-57-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Netilmicin sulfate 56391-57-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

56391-57-2, Netilmicin sulfate Related Search:

Copper(II) sulfate Sisomicin Aluminum sulfate 3-Aminophenol Glycine Barium sulfate Sodium thiosulfate Zinc sulfate heptahydrate ALTRENOGEST Ammonium sulfate Tris(hydroxymethyl)aminomethane Ferrous sulfate heptahydrate Vanadyl sulfate NETILMICIN 6-Aminocaproic acid Magnesium sulfate heptahydrate Sodium sulfate sulfate

D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-N1-ethyl-, sulfate (2:5)

Netilmicin sulfhate

Netilmicin sulfate(2:5)

Netilmicin sulphate, 1-N-Ethylsisomicin

6-diamino-2,3,4,6-tetradeoxy-alpha-d-glycero-hex-4-enopyranosyl-(1-4)-6)-o-(

netromycin

sulfate(2:5)(salt)

Sulfate NetilMicin

(2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4-amino-3-[[(2s,3r)-3-amino-6-(aminomethyl)-3,4-dihydro-2h-pyran-2-yl]oxy]-6-ethylamino-2-hydroxycyclohexyl]oxy-5-methyl-4-methylaminooxane-3,5-diol sulfate (2:5)

Netilmicin Sulfate (500 mg)

O-3-Deoxy-4-C-Methyl-3-(MethylaMino)-β-l-arabinopyranosyl-(1-6)-O-[2,6-diaMino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy-N'-ethyl-D-streptaMine

NETILMYCIN SULFATE USP27

O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy-N1-ethyl-D-streptamine sestersulfate

Netilmicin Impurity

Netilmicin Sulfate Usp

Netililn

Netromicine

O-3-Deoxy-4-C-methyl-3-(methylamino)-b-l-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy-Nethyl-D-streptamine

D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(16)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(14)]-2-deoxy-N1-ethyl-, sulfate (2:5) (salt) (9CI)

Zetamicin

Netilmicin sulfate (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4-Amino-3-[[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-6-ethylamino-2-hydroxycyclohexyl]oxy-5-methyl-4-methylaminooxane-3,5-diol sulfate (2:5)

O-3-Deoxy-4-C-methyl-3-methylamino-ss-L-arabinopyranosyl-(1->6)-O-[2, 6-diamino-4,5-dehydro-2,3,4,6-tetradeoxy-a-D-glycero-hexopyranosyl-(1->4)]-2-deoxy-1-N-ethyl-D-streptamine hemiheptasulfate

O-3-Deoxy-4-C-methyl-3-(methylamino)--l-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy-N’-ethyl-D-streptamine

4-O-[[3α-Amino-6-(aminomethyl)-3,4-dihydro-2H-pyran]-2α-yl]-6-O-[4-C-methyl-3-(methylamino)-3-deoxy-β-L-arabinopyranosyl]-N1-ethyl-2-deoxy-D-streptamine·2.5sulfuric acid

Netromycin sulfate

Netilmicin sulfate salt,1-N-Ethylsisomicin

1-N-ETHYLSISOMICIN

1-N-ETHYLSISOMICIN SULFATE

O-3-DEOXY-4-C-METHYL-3-METHYLAMINO-BETA-L-ARABINOPYRANOSYL-(1->6)-O-[2, 6-DIAMINO-4,5-DEHYDRO-2,3,4,6-TETRADEOXY-A-D-GLYCERO-HEXOPYRANOSYL-(1->4)]-2-DEOXY-1-N-ETHYL-D-STREPTAMINE HEMIHEPTASULFATE

NETILMICIN SULFATE

NETILMICIN SULFATE SALT

NETILMYCIN SULFATE

NETILMYCIN SULPHATE

NETILMICIN SULFATE USP EP

Netilmicin for peak identification

Netilmicin sulfate CRS

SCH-20569 (sulfate)

(2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-4-Amino-3-(((2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl)oxy)-6-(ethylamino)-2-hydroxycyclohexyl)oxy)-5-methyl-4-(methylamino)tetrahydro-2H-pyran-3,5-diol sulfate(2:5)

Netilmicin sulfate USP/EP/BP

Netilmicin Sulfate (SCH-20569)

Netilmicin Sulphate (NTC Sulphate), 595ug/mg

Netilmicin Sulfate (1460500)

Netilimicin (sulfate)

Netilmicin for peak identification CRS/C1A

Netilmicin sulfate for LC assay CRS/C1A

56391-57-2

C42H92N10O34S5

2C21H41N5O75H2SO4

C21H41N5O752H2SO4

C21H41N5O725H2SO4

C42H92N10O34S5C21H41N5O7freebase

C21H41N5O7H2SO4

2C21H41N5O75H2O4S

C21H41N5O725H2O4S

C21H41N5O7212H2SO4

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