ChemicalBook > CAS DataBase List > (4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one

(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one

Product Name: (4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one
CAS No.: 514-07-8
Chemical Name: (4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one
Synonyms: Tarxerone;Taraxeron;Taraxera-14-ene-3-one;D-Friedoolean-14-en-3-one;27-Norolean-14-en-3-one,13-methyl-, (13a)-;27-Norolean-14-en-3-one, 13-methyl-, (13α)-;Taraxerone, 98%, from Adenophora tetraphylla(Thunb.)Fisch;Aldehyde Dehydrogenase (ALDH),Taraxerone,Inhibitor,alcohol,enhancer,ALDH,inhibit,ADH;(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one;(4aR,6aR,8aR,12aR,12bS,14aR,14bR)-4,4,6a,8a,11,11,12b,14b-Octamethyl-1,4,4a,5,6,6a,8,8a,9,10,11,12,12a,12b,13,14,14a,14b-octadecahydropicen-3(2H)-one
CBNumber: CB71254045
Molecular Formula: C30H48O
Formula Weight: 424.7
MOL File: 514-07-8.mol

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(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one Property

Melting point:: 241-243 °C
Boiling point:: 488.3±44.0 °C(Predicted)
Density: 1.01±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
color: White to off-white
LogP: 10.480 (est)

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Safety

HS Code: 29143990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FT65698
Product name: Taraxerone
Packaging: 5mg
Price: $175
Updated: 2021/12/16

AK Scientific

Product number: W2550
Product name: Taraxerone
Packaging: 2mg
Price: $185
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT65698
Product name: Taraxerone
Packaging: 1mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT65698
Product name: Taraxerone
Packaging: 2mg
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: W2550
Product name: Taraxerone
Packaging: 5mg
Price: $286
Updated: 2021/12/16

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(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from light bamboo leaves and dandelion.

Uses

Taraxerone is isolated from Sedum sarmentosum. Taraxerone enhances effects on alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities with EC50 values of 512.42 and 500.16 μM, respectively[1].

Definition

ChEBI: A natural product found in Cupania cinerea.

in vivo

Taraxerone significantly lowers the plasma alcohol and acetaldehyde concentrations in mice. Compare to the control group, the ADH and ALDH expressions in the liver tissues are abruptly increased in the taraxerone-treated groups after ethanol exposure^[1]. Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease induced by ethanol administration^[1].

References

[1] Sung CK, et al. Taraxerone enhances alcohol oxidation via increases of alcohol dehyderogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities and gene expressions.Food Chem Toxicol. 2012 Jul;50(7):2508-14. DOI:10.1016/j.fct.2012.04.031

(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one manufacturers

Career Henan Chemical Co

Product: Taraxerone 514-07-8
Price: US $8.00/KG
Min. Order: 1KG
Purity: ＞98% HPLC
Supply Ability: 20 tons
Release date: 2020-02-17

514-07-8, (4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-oneRelated Search:

Terrestrosin D dipotassium dihydrogen 15alpha-hydroxy-2beta-[[2-O-isovaleryl-3,4-di-O-sulphonato-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioate Madecassic acid taraxasteryl acetate Madecassoside Taraxasterol roburic acid Poricoic acid A(F) Terrestrosin K ALLEOSIDE A Carboxyatractyloside Pachymic acid taraxerol acetate taraxerol

(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one

D-Friedoolean-14-en-3-one

Taraxera-14-ene-3-one

Taraxerone, 98%, from Adenophora tetraphylla(Thunb.)Fisch

Taraxeron

27-Norolean-14-en-3-one,13-methyl-, (13a)-

Tarxerone

27-Norolean-14-en-3-one, 13-methyl-, (13α)-

Aldehyde Dehydrogenase (ALDH),Taraxerone,Inhibitor,alcohol,enhancer,ALDH,inhibit,ADH

(4aR,6aR,8aR,12aR,12bS,14aR,14bR)-4,4,6a,8a,11,11,12b,14b-Octamethyl-1,4,4a,5,6,6a,8,8a,9,10,11,12,12a,12b,13,14,14a,14b-octadecahydropicen-3(2H)-one

514-07-8