ChemicalBook > CAS DataBase List > 2-(4-Bromophenyl)-2-methylpropanenitrile

2-(4-Bromophenyl)-2-methylpropanenitrile

Product Name: 2-(4-Bromophenyl)-2-methylpropanenitrile
CAS No.: 101184-73-0
Chemical Name: 2-(4-Bromophenyl)-2-methylpropanenitrile
Synonyms: CHEMBOOK;α,α-Dimethyl 4-bromophenylacetonitrile;2-(4-BROMOPHENYL)-2-METHYLPROPIONITRILE;P-Bromo a,a-Dimethyl Phenyl Acetonitrile;2-(4-BROMOPHENYL)-2-METHYLPROPANENITRILE;Benzeneacetonitrile,4-bromo-a,a-dimethyl-;Benzeneacetonitrile, 4-bromo-α,α-dimethyl-;2-(4-Bromophenyl)-2-methylpropanenitrile-2;2-(4-Bromophenyl)-2-methylpropanenitrile 98%;ALPHA,ALPHA-DIMETHYL-4-BROMOPHENYLACETONITRILE
CBNumber: CB7125423
Molecular Formula: C10H10BrN
Formula Weight: 224.1
MOL File: 101184-73-0.mol

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2-(4-Bromophenyl)-2-methylpropanenitrile Property

Melting point:: 110-113
Boiling point:: 299.8±15.0 °C(Predicted)
Density: 1.352±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
color: Colorless to Light yellow
CAS DataBase Reference: 101184-73-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-51
Hazard Note: Irritant/Keep Cold
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H411Toxic to aquatic life with long lasting effects

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5950
Product name: 2-(4-Bromophenyl)-2-methylpropanenitrile
Packaging: 200MG
Price: $53
Updated: 2025/07/31

TCI Chemical

Product number: B5950
Product name: 2-(4-Bromophenyl)-2-methylpropanenitrile
Packaging: 1G
Price: $158
Updated: 2025/07/31

TRC

Product number: B698393
Product name: 2-(4-Bromophenyl)-2-methylpropanenitrile
Packaging: 1g
Price: $75
Updated: 2021/12/16

TRC

Product number: B698393
Product name: 2-(4-Bromophenyl)-2-methylpropanenitrile
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB149508
Product name: 2-(4-Bromophenyl)-2-methylpropanenitrile
Packaging: 500mg
Price: $60
Updated: 2021/12/16

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2-(4-Bromophenyl)-2-methylpropanenitrile Chemical Properties,Usage,Production

Synthesis

16532-79-9

74-88-4

101184-73-0

A solution was prepared by dissolving 4-bromophenylacetonitrile (10.0 g, 51.0 mmol) in tetrahydrofuran (200 mL) at room temperature. Subsequently, the solution was slowly added dropwise to a suspension of sodium hydride (60% mineral oil dispersion, 6.0 g, 153 mmol) in tetrahydrofuran (400 mL) for 30 min. Upon completion of the dropwise addition, iodomethane (7.6 mL, 122 mmol) was slowly added over a period of 30 min, during which time a water bath was occasionally used to cool the reaction to maintain the reaction temperature below 40 °C. The reaction mixture was stirred at room temperature. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the mixture was poured into water (500 mL) and extracted with ethyl acetate (2 x 300 mL). The organic layers were combined, washed sequentially with brine (2 x 300 mL), dried over anhydrous magnesium sulfate, filtered and the solvent was concentrated. The crude product was purified by silica gel column chromatography using hexane solution containing 2% ethyl acetate as eluent to afford 2-(4-bromophenyl)-2-methylpropionitrile (11 g, 96% yield) as a yellow oil.1H NMR (300 MHz, CDCl3) δ ppm: 1.7 (s, 6H), 7.35 (dd, 2H), 7.53 (dd, 2H).

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 24, p. 7953 - 7967
[2] Patent: US2009/12123, 2009, A1. Location in patent: Page/Page column 5
[3] Patent: US2010/197591, 2010, A1. Location in patent: Page/Page column 29
[4] Patent: EP1870099, 2007, A1. Location in patent: Page/Page column 7-8
[5] Patent: US2012/108574, 2012, A1. Location in patent: Page/Page column 111

2-(4-Bromophenyl)-2-methylpropanenitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(4-Bromophenyl)-2-methylpropanenitrile manufacturers

Career Henan Chemical Co

Product: 2-(4-Bromophenyl)-2-methylpropanenitrile 101184-73-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-07-03

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