ChemicalBook > CAS DataBase List > 1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione

1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione

Product Name
1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione
CAS No.
6812-87-9
Chemical Name
1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione
Synonyms
NSC 122417;12-Hydroxyabieta-8,12-diene-11,14-dione;12-Hydroxy-13-isopropylpodocarpa-8,12-diene-11,14-dione;1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophen threne-3,4-dione;1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione;(4bS)-2-Isopropyl-3-hydroxy-4bα,8,8-trimethyl-4b,5,6,7,8,8aβ,9,10-octahydrophenanthrene-1,4-dione;(4bS,8aS)-4b,5,6,7,8,8a,9,10-Octahydro-3-hydroxy-4b,8,8-trimethyl-2-isopropyl-1,4-phenanthrenedione;(4bS,8aS)-3-hydroxy-2-isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-1,4-dione;1,4-Phenanthrenedione, 4b,5,6,7,8,8a,9,10-octahydro-3-hydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)-
CBNumber
CB71255648
Molecular Formula
C20H28O3
Formula Weight
316.43
MOL File
6812-87-9.mol
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1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione Property

Melting point:
181.5-183.0 °C(Solv: acetic acid (64-19-7))
Boiling point:
426.4±45.0 °C(Predicted)
Density 
1.12±0.1 g/cm3(Predicted)
pka
4.50±1.00(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom
Product number
CFN96006
Product name
Royleanone
Packaging
5mg
Price
$513
Updated
2021/12/16
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1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione Chemical Properties,Usage,Production

Uses

Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells[1].

Definition

ChEBI: Royleanone is a diterpenoid.

References

[1] Wu X, et al. Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway. J BUON. 2018 Jul-Aug;23(4):1055-1060. PMID:30358211

1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione Suppliers

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6812-87-9, 1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dioneRelated Search:

Hydroxyecdysone alpha-Cyperone MOSLOFLAVONE hydroxygenkwanin alpha-Terpineol (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one Artemether 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one beta-Eudesmol beta-Sitosterol

  • 1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione
  • (4bS)-2-Isopropyl-3-hydroxy-4bα,8,8-trimethyl-4b,5,6,7,8,8aβ,9,10-octahydrophenanthrene-1,4-dione
  • (4bS,8aS)-4b,5,6,7,8,8a,9,10-Octahydro-3-hydroxy-4b,8,8-trimethyl-2-isopropyl-1,4-phenanthrenedione
  • 12-Hydroxyabieta-8,12-diene-11,14-dione
  • 12-Hydroxy-13-isopropylpodocarpa-8,12-diene-11,14-dione
  • NSC 122417
  • 1,4-Phenanthrenedione, 4b,5,6,7,8,8a,9,10-octahydro-3-hydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)-
  • (4bS,8aS)-3-hydroxy-2-isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-1,4-dione
  • 1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophen threne-3,4-dione
  • 6812-87-9