Pseudouridine
- Product Name
- Pseudouridine
- CAS No.
- 1445-07-4
- Chemical Name
- Pseudouridine
- Synonyms
- PSEUDOURIDINE;Pseudo-UTP;5-Ribosyluracil;β-Pseudouridine;5-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione;y-Uridine;NSC 162405;Pseudoruidine;Pseudourindine;Pseudouricdine
- CBNumber
- CB7125832
- Molecular Formula
- C9H12N2O6
- Formula Weight
- 244.2
- MOL File
- 1445-07-4.mol
Pseudouridine Property
- Melting point:
- 222 °C
- Density
- 1.641±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Methanol (Very Slightly, Heated), Water (Slightly, Sonicated, Heated)
- pka
- 8.52±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- λmax
- 264nm(MeOH)(lit.)
- InChI
- InChI=1/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/s3
- InChIKey
- PTJWIQPHWPFNBW-IZFRNLNUNA-N
- SMILES
- O[C@@H]1[C@@H]([C@@H](CO)O[C@H]1C1=CNC(=O)NC1=O)O |&1:1,2,3,7,r|
Safety
- HS Code
- 2934.99.9001
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P2396
- Product name
- Pseudouridine
- Purity
- >98.0%(HPLC)
- Packaging
- 50mg
- Price
- $393
- Updated
- 2024/03/01
- Product number
- 23383
- Product name
- β-Pseudouridine
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 23383
- Product name
- β-Pseudouridine
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $175
- Updated
- 2024/03/01
- Product number
- 23383
- Product name
- β-Pseudouridine
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $385
- Updated
- 2024/03/01
- Product number
- P839605
- Product name
- β-Pseudouridine
- Packaging
- 2.5mg
- Price
- $55
- Updated
- 2021/12/16
Pseudouridine Chemical Properties,Usage,Production
Description
β-Pseudouridine is the C-5 glycoside isomer of the nucleoside uridine. It is formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme. Pseudouridine is found in tRNAs from bacteria, archaea, and eukaryotes. In vitro, it reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner.
Uses
An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.
Definition
ChEBI: Pseudouridine is a C-glycosyl pyrimidine that consists of uracil having a beta-D-ribofuranosyl residue attached at position 5. The C-glycosyl isomer of the nucleoside uridine. It has a role as a fundamental metabolite.
Origin
Pseudouridine (Ψ) was the first modified ribonucleotide discovered 7 decades ago, and it has been found in tRNA, rRNA, snRNA, mRNA, and other types of RNA[2].
Biochem/physiol Actions
Pseudouridine is essential for rRNA folding and for regulating translational accuracy and it is required for stabilizing the tRNA structure. Pseudouridine in rRNA and tRNA has been shown to fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation. Pseudouridine in snRNA has been shown to enhance spliceosomal RNA-pre-mRNA interaction to facilitate splicing regulation[1].
target
Human Endogenous Metabolite
Structure and conformation
Pseudouridine, being one of them, is the C5-glycoside isomer of uridine that contains a C-C bond between C1 of the ribose sugar and C5 of uracil, rather than usual C1-N1 bond found in uridine. The C-C bond gives it more rotational freedom and conformational flexibility.In addition, pseudouridine has an extra hydrogen bond donor at the N1 position.
References
[1] Mingjia Chen, Claus-Peter Witte. “A Kinase and a Glycosylase Catabolize Pseudouridine in the Peroxisome to Prevent Toxic Pseudouridine Monophosphate Accumulation.” Plant Cell 32 3 (2020): 722–739.
[2] Pedro Morais, Yi-Tao Yu, Hironori Adachi. “The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines.” Frontiers in Cell and Developmental Biology (2021): 789427.
Pseudouridine Preparation Products And Raw materials
Raw materials
Preparation Products
Pseudouridine Suppliers
- Tel
- 0571-89903882 13626641628
- jiangnan@huidabiotech.com
- Country
- China
- ProdList
- 3661
- Advantage
- 58
- Tel
- 0553-8233716 18055326116
- kendoll@cqpharm.com
- Country
- China
- ProdList
- 647
- Advantage
- 58
- Tel
- 0755-0755-27208059 13342904611
- Fax
- 0755-27208059
- Alex@hygieia.com.cn
- Country
- China
- ProdList
- 49
- Advantage
- 58
- Tel
- 13774177198
- qjuyd@126.com
- Country
- China
- ProdList
- 21
- Advantage
- 58
- Tel
- 13510071690 13510071690
- liya@zhouzyme.com
- Country
- China
- ProdList
- 11
- Advantage
- 58
- Tel
- 18221553137
- ddwuyu@126.com
- Country
- China
- ProdList
- 440
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-64757213
- Fax
- 86-21-64700613
- info@hongene.com
- Country
- China
- ProdList
- 672
- Advantage
- 61
- Tel
- 021-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6011
- Advantage
- 61
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24539
- Advantage
- 81
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- zhangsn@titansci.com
- Country
- China
- ProdList
- 14113
- Advantage
- 59
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11660
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Country
- China
- ProdList
- 4550
- Advantage
- 62
- Tel
- +86 (25) 82263158
- Fax
- +86 (25) 82263168
- Country
- China
- ProdList
- 262
- Advantage
- 60
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9900
- Advantage
- 58
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10269
- Advantage
- 58
- Tel
- 0371-85513397
- info@granlen.com
- Country
- China
- ProdList
- 497
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7854
- Advantage
- 58
- Tel
- +86-18921203887
- Fax
- +86-0510-86319635 ; QQ:1622023101
- sales@canalpharm.net
- Country
- China
- ProdList
- 289
- Advantage
- 58
- Tel
- 025-52164950
- Fax
- 025-86800069
- Googlexu_0114@sina.com
- Country
- China
- ProdList
- 644
- Advantage
- 58
- Tel
- 400-1647117 15221909166
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41438
- Advantage
- 60
- Tel
- +86-13439059536 +86-15201677815
- Country
- China
- ProdList
- 291
- Advantage
- 58
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 17994
- Advantage
- 56
- Tel
- 18040571231/1402788087
- Fax
- sales@chemduro.com
- Country
- China
- ProdList
- 1973
- Advantage
- 58
- Tel
- 010-61241352 18901327973
- sales@qlmed.com
- Country
- China
- ProdList
- 516
- Advantage
- 58
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9636
- Advantage
- 58
- Tel
- 86-574-27787657
- Fax
- 86-574-27912196
- info@dearchem.com
- Country
- China
- ProdList
- 4619
- Advantage
- 58
- Tel
- 15221275939 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 15878
- Advantage
- 55
- Tel
- 021-021-20956531 18116226605
- Fax
- 021-20956532
- sui@neosunpharm.com
- Country
- China
- ProdList
- 350
- Advantage
- 55
- Tel
- +86-571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 10015
- Advantage
- 53
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9767
- Advantage
- 58
- Tel
- 0576-84613060 13093829633
- Fax
- 0576-84613060
- sales@kedechemical.com
- Country
- China
- ProdList
- 298
- Advantage
- 60
- Tel
- 027-027-59207879 18140587686
- Fax
- QQ：1972026995
- kf@3600chem.com
- Country
- China
- ProdList
- 4697
- Advantage
- 55
- Tel
- 022-022-25327698 18920479040
- sales@cosychem.com
- Country
- China
- ProdList
- 588
- Advantage
- 55
- Tel
- 021-61984905-1 18016477331
- synchempharma@aliyun.com
- Country
- China
- ProdList
- 6455
- Advantage
- 55
- Tel
- 0553-8233716 18055326116
- sales@nuowei-chem.com
- Country
- China
- ProdList
- 950
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9709
- Advantage
- 58
- Tel
- 0510-88770633 13961738808
- jingyaobiotech@126.com
- Country
- China
- ProdList
- 311
- Advantage
- 55
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- 021-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 9038
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131981
- Advantage
- 58
- Tel
- 17721395025
- Fax
- 021-68882955
- 2423903095@qq.com
- Country
- China
- ProdList
- 3153
- Advantage
- 58
- Tel
- 0551-65171243 13810511747
- kuer@kuerhuaxue.com
- Country
- China
- ProdList
- 2997
- Advantage
- 55
- Tel
- 027-027-83778875 15807197853
- Fax
- 027-83991220
- 15807197853@163.com
- Country
- China
- ProdList
- 3979
- Advantage
- 58
- Tel
- 021-58180488
- Fax
- 021-58180499
- sales@MedChemLeader.com
- Country
- China
- ProdList
- 999
- Advantage
- 58
- Tel
- 021-021-52271985 17721149837
- Fax
- +86 (21) 52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 19806
- Advantage
- 60
- Tel
- 571-85586718 +8613336195806
- Fax
- +86-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 29797
- Advantage
- 60
- Tel
- 025-66113011 18112977050
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16028
- Advantage
- 58
- Tel
- 021-61469567 18521078705
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 19942
- Advantage
- 58
View Lastest Price from Pseudouridine manufacturers
- Product
- Pseudouridine 1445-07-4
- Price
- US $0.00-0.00/g
- Min. Order
- 10g
- Purity
- 99.5%
- Supply Ability
- 100kg monthly
- Release date
- 2022-02-24
- Product
- Pseudouridine 1445-07-4
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 1000g
- Release date
- 2021-08-30
- Product
- Pseudouridine 1445-07-4
- Price
- US $0.00/g
- Min. Order
- 10g
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2023-05-09