ChemicalBook > CAS DataBase List > 6-Chloroquinazoline-2,4(1H,3H)-dione
6-Chloroquinazoline-2,4(1H,3H)-dione
- Product Name
- 6-Chloroquinazoline-2,4(1H,3H)-dione
- CAS No.
- 1640-60-4
- Chemical Name
- 6-Chloroquinazoline-2,4(1H,3H)-dione
- Synonyms
- NSC 194820;6-Chloro-2,4-quinazolinediol;6-chloroquinazoline-2,4-diol;6-Chloroquinazoline-2,4-dione;6-chloro-1H-quinazoline-2,4-dione;6-chloro-1H-quinazoline-2,4-quinone;6-Chloroquinazolin-2,4(1H,3H)-dione;6-Chloroquinazoline-2,4(1H,3H)-dione;2,4(1H,3H)-Quinazolinedione, 6-chloro-;6-Chloro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline
- CBNumber
- CB71263218
- Molecular Formula
- C8H5ClN2O2
- Formula Weight
- 196.59
- MOL File
- 1640-60-4.mol
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6-Chloroquinazoline-2,4(1H,3H)-dione Property
- Melting point:
- 360℃ (acetic acid )
- Density
- 1.475±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 10.02±0.20(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C8H5ClN2O2/c9-4-1-2-6-5(3-4)7(12)11-8(13)10-6/h1-3H,(H2,10,11,12,13)
- InChIKey
- IGWJEWGQUFOVDP-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(Cl)C=C2)C(=O)NC1=O
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Safety
- Hazard Codes
- Xi
- HS Code
- 2933599590
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- C429323
- Product name
- 6-Chloroquinazoline-2,4(1H,3H)-dione
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0013733
- Product name
- 6-CHLOROQUINAZOLINE-2,4(1H,3H)-DIONE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $635.71
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0013733
- Product name
- 6-CHLOROQUINAZOLINE-2,4(1H,3H)-DIONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $752.14
- Updated
- 2021/12/16
AK Scientific
- Product number
- W3575
- Product name
- 6-Chloroquinazoline-2,4(1H,3H)-dione
- Packaging
- 100mg
- Price
- $119
- Updated
- 2021/12/16
AK Scientific
- Product number
- W3575
- Product name
- 6-Chloroquinazoline-2,4(1H,3H)-dione
- Packaging
- 1g
- Price
- $162
- Updated
- 2021/12/16
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6-Chloroquinazoline-2,4(1H,3H)-dione Chemical Properties,Usage,Production
Synthesis
124-38-9
5922-60-1
1640-60-4
Under argon protection, 2-amino-5-chlorobenzonitrile (1 mmol) was dissolved in DMSO-d6 (1 mL), catalyst (0.01 mmol) was added and placed in a stainless steel autoclave. The autoclave was sealed, heated to 110 °C, and then carbon dioxide was introduced to reach a pressure of 2 MPa. The reaction mixture was subjected to cyclization by magnetic stirring at 110 °C for 3 h. After the reaction was completed, the autoclave was placed in the autoclave and the catalyst was added to the reaction mixture. Upon completion of the reaction, the autoclave was cooled in an ice bath and the pressure was slowly released. The chemical yield of 6-chloroquinazoline-2,4-dione was determined by 1H NMR analysis using 3,5-dimethoxybenzyl alcohol as an internal standard. Following the same procedure, a DMSO solution (6 mL) of 2-amino-5-chlorobenzonitrile (6 mmol) was subjected to a carboxycyclization reaction with carbon dioxide. After the reaction, the autoclave was cooled and depressurized and the reaction mixture was poured into water (60 mL). The precipitate was collected by filtration, washed sequentially with water and ether, and finally dried under vacuum at 35 °C for 15 h to give pure 6-chloroquinazoline-2,4-dione.
References
[1] Heteroatom Chemistry, 2012, vol. 23, # 3, p. 276 - 280
[2] RSC Advances, 2015, vol. 5, # 7, p. 5032 - 5037
[3] Tetrahedron, 2018, vol. 74, # 24, p. 2914 - 2920
[4] Green Chemistry, 2014, vol. 16, # 6, p. 3142 - 3148
[5] Tetrahedron, 2002, vol. 58, # 16, p. 3155 - 3158
6-Chloroquinazoline-2,4(1H,3H)-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chloroquinazoline-2,4(1H,3H)-dione manufacturers
Career Henan Chemical Co
- Product
- 6-Chloroquinazoline-2,4(1H,3H)-dione 1640-60-4
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 90%-99.9%
- Supply Ability
- 1000kg
- Release date
- 2019-07-04
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