ChemicalBook > CAS DataBase List > 6-Chloroquinazoline-2,4(1H,3H)-dione

6-Chloroquinazoline-2,4(1H,3H)-dione

Product Name
6-Chloroquinazoline-2,4(1H,3H)-dione
CAS No.
1640-60-4
Chemical Name
6-Chloroquinazoline-2,4(1H,3H)-dione
Synonyms
NSC 194820;6-Chloro-2,4-quinazolinediol;6-chloroquinazoline-2,4-diol;6-Chloroquinazoline-2,4-dione;6-chloro-1H-quinazoline-2,4-dione;6-chloro-1H-quinazoline-2,4-quinone;6-Chloroquinazolin-2,4(1H,3H)-dione;6-Chloroquinazoline-2,4(1H,3H)-dione;2,4(1H,3H)-Quinazolinedione, 6-chloro-;6-Chloro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline
CBNumber
CB71263218
Molecular Formula
C8H5ClN2O2
Formula Weight
196.59
MOL File
1640-60-4.mol
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6-Chloroquinazoline-2,4(1H,3H)-dione Property

Melting point:
360℃ (acetic acid )
Density 
1.475±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
10.02±0.20(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C8H5ClN2O2/c9-4-1-2-6-5(3-4)7(12)11-8(13)10-6/h1-3H,(H2,10,11,12,13)
InChIKey
IGWJEWGQUFOVDP-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(Cl)C=C2)C(=O)NC1=O
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Safety

Hazard Codes 
Xi
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C429323
Product name
6-Chloroquinazoline-2,4(1H,3H)-dione
Packaging
100mg
Price
$60
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0013733
Product name
6-CHLOROQUINAZOLINE-2,4(1H,3H)-DIONE
Purity
95.00%
Packaging
250MG
Price
$635.71
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0013733
Product name
6-CHLOROQUINAZOLINE-2,4(1H,3H)-DIONE
Purity
95.00%
Packaging
1G
Price
$752.14
Updated
2021/12/16
AK Scientific
Product number
W3575
Product name
6-Chloroquinazoline-2,4(1H,3H)-dione
Packaging
100mg
Price
$119
Updated
2021/12/16
AK Scientific
Product number
W3575
Product name
6-Chloroquinazoline-2,4(1H,3H)-dione
Packaging
1g
Price
$162
Updated
2021/12/16
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6-Chloroquinazoline-2,4(1H,3H)-dione Chemical Properties,Usage,Production

Synthesis

124-38-9

5922-60-1

1640-60-4

Under argon protection, 2-amino-5-chlorobenzonitrile (1 mmol) was dissolved in DMSO-d6 (1 mL), catalyst (0.01 mmol) was added and placed in a stainless steel autoclave. The autoclave was sealed, heated to 110 °C, and then carbon dioxide was introduced to reach a pressure of 2 MPa. The reaction mixture was subjected to cyclization by magnetic stirring at 110 °C for 3 h. After the reaction was completed, the autoclave was placed in the autoclave and the catalyst was added to the reaction mixture. Upon completion of the reaction, the autoclave was cooled in an ice bath and the pressure was slowly released. The chemical yield of 6-chloroquinazoline-2,4-dione was determined by 1H NMR analysis using 3,5-dimethoxybenzyl alcohol as an internal standard. Following the same procedure, a DMSO solution (6 mL) of 2-amino-5-chlorobenzonitrile (6 mmol) was subjected to a carboxycyclization reaction with carbon dioxide. After the reaction, the autoclave was cooled and depressurized and the reaction mixture was poured into water (60 mL). The precipitate was collected by filtration, washed sequentially with water and ether, and finally dried under vacuum at 35 °C for 15 h to give pure 6-chloroquinazoline-2,4-dione.

References

[1] Heteroatom Chemistry, 2012, vol. 23, # 3, p. 276 - 280
[2] RSC Advances, 2015, vol. 5, # 7, p. 5032 - 5037
[3] Tetrahedron, 2018, vol. 74, # 24, p. 2914 - 2920
[4] Green Chemistry, 2014, vol. 16, # 6, p. 3142 - 3148
[5] Tetrahedron, 2002, vol. 58, # 16, p. 3155 - 3158

6-Chloroquinazoline-2,4(1H,3H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chloroquinazoline-2,4(1H,3H)-dione Suppliers

China 80 Germany 1 India 1 United Kingdom 1 United States 6 Global 89
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 6-Chloroquinazoline-2,4(1H,3H)-dione manufacturers

Career Henan Chemical Co
Product
6-Chloroquinazoline-2,4(1H,3H)-dione 1640-60-4
Price
US $3.00/KG
Min. Order
1KG
Purity
90%-99.9%
Supply Ability
1000kg
Release date
2019-07-04

1640-60-4, 6-Chloroquinazoline-2,4(1H,3H)-dioneRelated Search:

Benzoyleneurea 6-Chloroquinazoline-2,4(1H,3H)-dione 3-CHLOROBENZYL UREA 2-(Methylaminomethyl)aniline 6,8-DICHLORO-2,5-(1H,3H)QUINAZOLEINEDIONE 2-(AMINOMETHYL)-4-CHLORO-N-METHYLBENZENAMINE 2-Amino-5-chlorobenzamide 3-CHLOROBENZAMIDE 2-(AMINOMETHYL)-4-CHLOROANILINE 2-Amino-5-chlorobenzaldehyde 2-AMINO-N-METHYLBENZAMIDE 3-CHLORO-N-METHYLBENZYLAMINE BENZOYLUREA 3,4-DIHYDROQUINAZOLIN-2(1H)-ONE 2-METHYLAMINOBENZAMIDE

  • 6-Chloroquinazoline-2,4(1H,3H)-dione
  • 6-Chloroquinazoline-2,4-dione
  • 6-chloroquinazoline-2,4-diol
  • 6-chloro-1,2,3,4-tetrahydroquinazoline-2,4-dione
  • 6-Chloro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline
  • 6-Chloro-2,4-quinazolinediol
  • 6-Chloroquinazolin-2,4(1H,3H)-dione
  • NSC 194820
  • 6-chloro-1H-quinazoline-2,4-dione
  • 6-chloro-1H-quinazoline-2,4-quinone
  • 2,4(1H,3H)-Quinazolinedione, 6-chloro-
  • 6-Chloroquinazoline-2,4(1H,3H)-dione ISO 9001：2015 REACH
  • 1640-60-4
  • blocks
  • Quinolines