5-Acetonyl-2-methoxybenzene sulfonamide

Product Name: 5-Acetonyl-2-methoxybenzene sulfonamide
CAS No.: 116091-63-5
Chemical Name: 5-Acetonyl-2-methoxybenzene sulfonamide
Synonyms: Tamsulosin Impurity 4;Tamsulosin Impurity 10;5-Acetonyl-2-methoxybenzene;5-(2-Oxypropyl)-2-methoxybenze;3-SulfoMoyl-4-Methoxy phenyl acetone;5-ACETONYL-2-METHOXYBENZENE SULFOMIDE;5-ACETONYL-2-METHOXYBENZENE SULFONAMIDE;5-ACETONYL-2-METHOXYBENZENE SULPHONAMIDE;5-(2-OXPROPYL)-2-METHOXYBENZENESULPHONAMID;5-(2-Oxypropyl)-2-methoxybenzenesulfonamide
CBNumber: CB7126662
Molecular Formula: C10H13NO4S
Formula Weight: 243.28
MOL File: 116091-63-5.mol

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5-Acetonyl-2-methoxybenzene sulfonamide Property

Melting point:: 194-197°C
Boiling point:: 444.6±55.0 °C(Predicted)
Density: 1.288±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 9.91±0.60(Predicted)
color: Light Beige
InChI: InChI=1S/C10H13NO4S/c1-7(12)5-8-3-4-9(15-2)10(6-8)16(11,13)14/h3-4,6H,5H2,1-2H3,(H2,11,13,14)
InChIKey: MQQJFLHZXQRKKJ-UHFFFAOYSA-N
SMILES: C1(S(N)(=O)=O)=CC(CC(=O)C)=CC=C1OC
CAS DataBase Reference: 116091-63-5(CAS DataBase Reference)

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Safety

HS Code: 2935.90.9500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS003211
Product name: 2-methoxy-5-(2-oxo-propyl)benzenesulfonamide
Purity: AldrichCPR
Packaging: 1G
Price: $68.1
Updated: 2023/06/20

TCI Chemical

Product number: A2948
Product name: 5-Acetonyl-2-methoxybenzenesulfonamide
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $133
Updated: 2025/07/31

TCI Chemical

Product number: A2948
Product name: 5-Acetonyl-2-methoxybenzenesulfonamide
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $397
Updated: 2025/07/31

TRC

Product number: A163950
Product name: 5-Acetonyl-2-methoxybenzenesulfonamide
Packaging: 25g
Price: $875
Updated: 2021/12/16

Matrix Scientific

Product number: 126367
Product name: 5-Acetonyl-2-methoxybenzenesulfonamide
Purity: >95%
Packaging: 10g
Price: $216
Updated: 2021/12/16

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5-Acetonyl-2-methoxybenzene sulfonamide Chemical Properties,Usage,Production

Uses

5-Acetonyl-2-methoxybenzene sulfonamide can be used as Tamsulosine intermediate.

Uses

5-Acetonyl-2-methoxybenzene is used in the synthesis of tamsulosin, a drug used in benign prostatic hyperplasia therapy.

Synthesis

80223-79-6

116091-63-5

General procedure for the synthesis of 2-methoxy-5-(2-oxopropyl)benzenesulfonamide from 2-methoxy-5-(2-oxopropyl)benzenesulfonyl chloride: embodiment 6-comparison; method for the preparation of tamsulosin (II) according to the prior art as compared to the method comprising steps according to the present invention.1. Method according to the prior art: 1.1 According to US 4,731,478 (1988) , chlorosulfonation is carried out in two steps; 1.2 The yield of VII is 40% and the total yield of III is 30%.

References

[1] Patent: WO2005/75415, 2005, A1. Location in patent: Page/Page column 9
[2] Chemical and Pharmaceutical Bulletin, 1992, vol. 40, # 6, p. 1443 - 1451
[3] Patent: WO2003/72557, 2003, A1. Location in patent: Page/Page column 44-45
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 16, p. 3714 - 3718
[5] Patent: CN106631918, 2017, A. Location in patent: Paragraph 0152-0156

5-Acetonyl-2-methoxybenzene sulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Acetonyl-2-methoxybenzene sulfonamide Suppliers

Americas 1 Canada 1 China 198 Europe 1 Germany 4 India 39 Japan 2 South Korea 1 United Kingdom 5 United States 26 Global 278

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View Lastest Price from 5-Acetonyl-2-methoxybenzene sulfonamide manufacturers

Career Henan Chemical Co

Product: 5-Acetonyl-2-methoxybenzene sulfonamide 116091-63-5
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-07-31

116091-63-5, 5-Acetonyl-2-methoxybenzene sulfonamideRelated Search:

Acetamide,N-[(1R)-2-[3-(aminosulfonyl)-4-methoxyphenyl]-1-methylethyl]- (S)-2-(4-Methoxyphenyl)-1-MethylethanaMine Hydrochloride (R)-2-(4-Methoxyphenyl)-1-methylethanamine 4-Methoxybenzoic acid 3-(METHOXYMETHOXY)BENZALDEHYDE Sulfanilamide (Trifluoromethoxy)benzene p-Anisaldehyde 4-Methoxyphenylacetone 4'-Methoxyacetophenone Anisole Methoxyacetone 3-Methoxyacetophenone ALPHA-ACETYLPHENYLACETONITRILE Propiophenone 1-Bromo-1-phenyl-2-propanone 5-Acetonyl-2-methoxybenzene sulfonamide 5-acetonyl-2-methoxybenzene sulfonamide (intermediate of tamsulosin)

5-ACETONYL-2-METHOXYBENZENE SULFONAMIDE

5-ACETONYL-2-METHOXYBENZENE SULPHONAMIDE

5-(2-Oxypropyl)-2-methoxybenzenesulfonamide

5-(2-OXYPROPYL)-2-METHOXYBENZENE SULPHONAMIDE 98+%

5-(2-OXOPROPYL)-2-METHOXY BENZENE SULPHONAMIDE

2-METHOXY-5-(2-OXO-PROPYL)BENZENESULFONAMIDE

2-METHOXY-5-(2-OXOPROPYL)BENZENE SULPHONAMIDE

5-(2-Oxypropyl)-2-methoxybenze

5-(2-OXPROPYL)-2-METHOXYBENZENESULPHONAMID

5-(2-Oxypropyl)-2-methoxybenzene sulphonamide

5-Acetonyl-2-methoxybenzene

3-SulfoMoyl-4-Methoxy phenyl acetone

Tamsulosin Impurity 10

Tamsulosin Impurity 4

5-ACETONYL-2-METHOXYBENZENE SULFOMIDE

Benzenesulfonamide, 2-methoxy-5-(2-oxopropyl)-

TIANFU CHEM---5-Acetonyl-2-methoxybenzene sulfonamide

5-ACETONYL-2-METHOXYBENZENE SULFONAMIDE(50 GMS)

5-Acetonyl-2-methoxybenzenesulfonic acid ammonium

116091-63-5

16091-63-5

C10H13NO4S

Tamsulosin

Valsartan

API intermediates

(intermediate of tamsulosin)