(S,S)-Formoterol

Product Name: (S,S)-Formoterol
CAS No.: 67346-48-9
Chemical Name: (S,S)-Formoterol
Synonyms: (S,S)-Formoterol;Formoterol Impurity 15;2-amino-1-(3-amino-4-(benzyloxy)phenyl)ethan-1-ol;2-amino-1-(3-amino-4-(benzyloxy)phenyl)ethan-1-ol dihydrochloride;N-[2-Hydroxy-5-[(1S)-1-hydroxy-2-[[(αS)-α-methyl-4-methoxyphenethyl]amino]ethyl]phenyl]formamide;N-(2-hydroxy-5-((S)-1-hydroxy-2-(((S)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide;N-[2-Hydroxy-5-[(S)-1-hydroxy-2-[[(S)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide;Formamide, N-[2-hydroxy-5-[(1S)-1-hydroxy-2-[[(1S)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-;Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, [S-(R*,R*)]-
CBNumber: CB71270326
Molecular Formula: C19H24N2O4
Formula Weight: 344.4
MOL File: 67346-48-9.mol

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(S,S)-Formoterol Property

Boiling point:: 603.2±55.0 °C(Predicted)
Density: 1.233±0.06 g/cm3(Predicted)
pka: 8.95±0.50(Predicted)

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Hazard and Precautionary Statements (GHS)

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(S,S)-Formoterol Chemical Properties,Usage,Production

Uses

(S,S)-Formoterol ((+)-Formoterol) is a (S,S)-enantiomer of Formoterol. (S,S)-Formoterol can promote asthma by enhancing IL-4 production in mast cells of the asthmatic airway[1].

Definition

ChEBI: (S,S)-formoterol is an N-[2-hydroxy-5-(1-hydroxy-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethyl)phenyl]formamide in which both of the stereocentres have S configuration. It is a conjugate base of a (S,S)-formoterol(1+). It is an enantiomer of an arformoterol.

References

[1] Abraha D, et, al. (S,S)-formoterol increases the production of IL-4 in mast cells and the airways of a murine asthma model. Int Arch Allergy Immunol. 2004 Apr;133(4):380-8. DOI:10.1159/000077358
[2] Jensen O, et, al. Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters. Biochem Pharmacol. 2020 Jan;171:113731. DOI:10.1016/j.bcp.2019.113731

(S,S)-Formoterol Preparation Products And Raw materials

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(S,S)-Formoterol Suppliers

China 25 India 3 United States 2 Global 30

Daicel Chiral Technologies (China)CO.,LTD

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67346-48-9, (S,S)-FormoterolRelated Search:

N,O-Dibenzylated formoterol 4-methoxyamphetamine hydrochloride Formamide, N-[2-(4-methoxyphenyl)-1-methylethyl]- Formoterol EP Impurity F 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone Formoterol EP Impurity E Arformoterol Impurity 24 Formoterol O-β-D-Glucuronide (R,R)-Formoterol Formoterol fumarate FORMOTEROL-D3 Formoterol Fumarate Dihydrate EP Impurity I Formoterol EP Impurity C 1-(4-Methoxyphenyl)-2-benzylaminopropane (R)-2-(4-Methoxyphenyl)-1-methylethanamine Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, [R-(R*,S*)]- Formoterol Impurity 13 Formoterol EP Impurity D

(S,S)-Formoterol

Formamide, N-[2-hydroxy-5-[(1S)-1-hydroxy-2-[[(1S)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-

Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, [S-(R*,R*)]-

N-[2-Hydroxy-5-[(1S)-1-hydroxy-2-[[(αS)-α-methyl-4-methoxyphenethyl]amino]ethyl]phenyl]formamide

N-[2-Hydroxy-5-[(S)-1-hydroxy-2-[[(S)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide

Formoterol Impurity 15

N-(2-hydroxy-5-((S)-1-hydroxy-2-(((S)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide

2-amino-1-(3-amino-4-(benzyloxy)phenyl)ethan-1-ol

2-amino-1-(3-amino-4-(benzyloxy)phenyl)ethan-1-ol dihydrochloride

67346-48-9