ChemicalBook > CAS DataBase List > 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI)
1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI)
- Product Name
- 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI)
- CAS No.
- 330681-18-0
- Chemical Name
- 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI)
- Synonyms
- (3R,4R)-3-Amino-1-Boc-4-hydroxypyrrolidine;(3R,4R)-4-aMino-1-N-Boc-3-hydroxypyrrolidine;Trans-(3R,4R)-1-Boc-3-aMino-4-hydroxypyrrolidine;rel-tert-Butyl (3R,4R)-3-amino-4-hydroxypyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI);1-Pyrrolidinecarboxylic acid, 3-amino-4-hydroxy-, 1,1-dimethylethyl ester, (3R,4R)-;1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) USP/EP/BP
- CBNumber
- CB71273918
- Molecular Formula
- C9H18N2O3
- Formula Weight
- 202.25
- MOL File
- 330681-18-0.mol
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1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) Property
- Boiling point:
- 308.8±42.0 °C(Predicted)
- Density
- 1.179
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 14.36±0.40(Predicted)
- Appearance
- White to off-white Solid
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Safety
- RIDADR
- 3259
- HazardClass
- 8
- PackingGroup
- Ⅲ
- HS Code
- 2933998090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-WAA0305
- Product name
- (3R,4R)-tert-Butyl3-amino-4-hydroxypyrrolidine-1-carboxylate
- Purity
- ≥97.0%
- Packaging
- 250mg
- Price
- $66
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-WAA0305
- Product name
- (3R,4R)-tert-Butyl3-amino-4-hydroxypyrrolidine-1-carboxylate
- Purity
- ≥97.0%
- Packaging
- 1g
- Price
- $163
- Updated
- 2021/12/16
AK Scientific
- Product number
- 3769AB
- Product name
- (3R,4R)-tert-Butyl3-amino-4-hydroxypyrrolidine-1-carboxylate
- Packaging
- 250mg
- Price
- $163
- Updated
- 2021/12/16
AK Scientific
- Product number
- 3769AB
- Product name
- (3R,4R)-tert-Butyl3-amino-4-hydroxypyrrolidine-1-carboxylate
- Packaging
- 1g
- Price
- $333.5
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H56-1-0NR
- Product name
- tert-Butyl (3R,4R)-3-amino-4-hydroxypyrrolidine-1-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $408
- Updated
- 2021/12/16
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1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) Chemical Properties,Usage,Production
Synthesis
1202067-36-4
330681-18-0
General procedure for the synthesis of tert-butyl (3R,4R)-3-amino-4-hydroxypyrrolidine-1-carboxylate from the compound (CAS:1202067-36-4): trifluoroacetic acid (3 drops) was added to a solution of intermediate 19 (2.5 g, 8.4 mmol) in methanol (50 mL), and the reaction mixture was stirred for 2 hours. Subsequently, platinum oxide (100 mg, 0.44 mmol) was added to the reaction system and stirring was continued for 18 hours under hydrogen atmosphere. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the solvent was removed by evaporation under vacuum. The resulting crude product was purified by recrystallization from dichloromethane to afford the target product (3R,4R)-tert-butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate as a white solid (1.5 g, 89% yield). NMR hydrogen spectrum (CDCl3) data: δ 3.99 (1H, m), 3.70 (2H, m), 3.34 (2H, m), 3.12 (1H, m), 1.48 (9H, s).
References
[1] Patent: WO2009/153554, 2009, A1. Location in patent: Page/Page column 43
1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) manufacturers
Career Henan Chemical Co
- Product
- 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) 330681-18-0
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2020-01-09
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