ChemicalBook > CAS DataBase List > 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI)

1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI)

Product Name
1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI)
CAS No.
330681-18-0
Chemical Name
1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI)
Synonyms
(3R,4R)-3-Amino-1-Boc-4-hydroxypyrrolidine;(3R,4R)-4-aMino-1-N-Boc-3-hydroxypyrrolidine;Trans-(3R,4R)-1-Boc-3-aMino-4-hydroxypyrrolidine;rel-tert-Butyl (3R,4R)-3-amino-4-hydroxypyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI);1-Pyrrolidinecarboxylic acid, 3-amino-4-hydroxy-, 1,1-dimethylethyl ester, (3R,4R)-;1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) USP/EP/BP
CBNumber
CB71273918
Molecular Formula
C9H18N2O3
Formula Weight
202.25
MOL File
330681-18-0.mol
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1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) Property

Boiling point:
308.8±42.0 °C(Predicted)
Density 
1.179
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
14.36±0.40(Predicted)
Appearance
White to off-white Solid
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Safety

RIDADR 
3259
HazardClass 
8
PackingGroup 
Ⅲ
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-WAA0305
Product name
(3R,4R)-tert-Butyl3-amino-4-hydroxypyrrolidine-1-carboxylate
Purity
≥97.0%
Packaging
250mg
Price
$66
Updated
2021/12/16
ChemScene
Product number
CS-WAA0305
Product name
(3R,4R)-tert-Butyl3-amino-4-hydroxypyrrolidine-1-carboxylate
Purity
≥97.0%
Packaging
1g
Price
$163
Updated
2021/12/16
AK Scientific
Product number
3769AB
Product name
(3R,4R)-tert-Butyl3-amino-4-hydroxypyrrolidine-1-carboxylate
Packaging
250mg
Price
$163
Updated
2021/12/16
AK Scientific
Product number
3769AB
Product name
(3R,4R)-tert-Butyl3-amino-4-hydroxypyrrolidine-1-carboxylate
Packaging
1g
Price
$333.5
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-0NR
Product name
tert-Butyl (3R,4R)-3-amino-4-hydroxypyrrolidine-1-carboxylate
Purity
97%
Packaging
1g
Price
$408
Updated
2021/12/16
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1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) Chemical Properties,Usage,Production

Synthesis

1202067-36-4

330681-18-0

General procedure for the synthesis of tert-butyl (3R,4R)-3-amino-4-hydroxypyrrolidine-1-carboxylate from the compound (CAS:1202067-36-4): trifluoroacetic acid (3 drops) was added to a solution of intermediate 19 (2.5 g, 8.4 mmol) in methanol (50 mL), and the reaction mixture was stirred for 2 hours. Subsequently, platinum oxide (100 mg, 0.44 mmol) was added to the reaction system and stirring was continued for 18 hours under hydrogen atmosphere. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the solvent was removed by evaporation under vacuum. The resulting crude product was purified by recrystallization from dichloromethane to afford the target product (3R,4R)-tert-butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate as a white solid (1.5 g, 89% yield). NMR hydrogen spectrum (CDCl3) data: δ 3.99 (1H, m), 3.70 (2H, m), 3.34 (2H, m), 3.12 (1H, m), 1.48 (9H, s).

References

[1] Patent: WO2009/153554, 2009, A1. Location in patent: Page/Page column 43

1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) Suppliers

China 59 Europe 1 India 1 United Kingdom 1 United States 6 Global 68
CHEMSTEP
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Email
info@chemstep.com
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Europe
ProdList
6143
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View Lastest Price from 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) manufacturers

Career Henan Chemical Co
Product
1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) 330681-18-0
Price
US $2.00/KG
Min. Order
1g
Purity
98%MIN
Supply Ability
ASK
Release date
2020-01-09

330681-18-0, 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI)Related Search:

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  • (3R,4R)-3-Amino-1-Boc-4-hydroxypyrrolidine
  • 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) USP/EP/BP
  • 330681-18-0
  • AMINOACID