ailanthone

ChemicalBook > CAS DataBase List > ailanthone

Product Name: ailanthone
CAS No.: 981-15-7
Chemical Name: ailanthone
Synonyms: ailanthone;Δ13-Dehydrochaparrinone;13,21-Didehydrochaparrinone;2H-1,11c-(Epoxymethano)phenanthro[10,1-bc]pyran-5,10(3H,6aH);(1beta,11alpha,12alpha)-1,11,12-trihydroxy-11,20-epoxypicras...;11β,20-Epoxy-1β,11,12α-trihydroxypicrasa-3,13(21)-diene-2,16-dione;(1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione;Picrasa-3,13(21)-diene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-, (1b,11b,12a)-;Picrasa-3,13(21)-diene-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-, (1β,11β,12α)-;(1R,2R,3aS,3a1S,6aR,7aS,11S,11aS,11bR)-1,2,11-Trihydroxy-8,11a-dimethyl-3-methylene-2,3,3a,4,7,7a,11,11a-octahydro-1H-1,3a1-(epoxymethano)dibenzo[de,g]chromene-5,10(6aH,11bH)-dione
CBNumber: CB71327541
Molecular Formula: C20H24O7
Formula Weight: 376.4
MOL File: 981-15-7.mol

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ailanthone Property

Melting point:: 235-237 °C
Boiling point:: 641.0±55.0 °C(Predicted)
Density: 1.47
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);265.67(Max Conc. mM)
form: A crystalline solid
pka: 11.85±0.70(Predicted)
color: White to off-white
LogP: -0.760 (est)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H300Fatal if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2143
Product name: Ailanthone
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $143
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML2143
Product name: Ailanthone
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $567
Updated: 2023/06/20

Cayman Chemical

Product number: 29194
Product name: Ailanthone
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 29194
Product name: Ailanthone
Packaging: 25mg
Price: $485
Updated: 2024/03/01

Cayman Chemical

Product number: 29194
Product name: Ailanthone
Packaging: 1mg
Price: $37
Updated: 2024/03/01

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ailanthone Chemical Properties,Usage,Production

Description

Ailanthone is a quassinoid that has been found in Ailanthus and has diverse biological activities. It is active against the P. falciparum strains HB-3 and Dd-2 in vitro (IC₅₀s = 0.003 and 0.037 μg/ml, respectively). Ailanthone is phytotoxic, inhibiting radish seed germination by 88% when used at a concentration of 1 mM. It inhibits dihydrotestosterone-induced androgen receptor transcriptional activity (IC₅₀ = 69 nM in a reporter assay), as well as the growth and colony formation of LNCaP and 22RV1 androgen receptor-expressing cells, but not androgen receptor-negative PC3 and DU145 cells, when used at a concentration of 0.1 μM. Ailanthone (2 mg/kg) reduces tumor volume in 22Rv1, LNCaP, and VCaP castration-resistant prostate cancer (CRPC) mouse xenograft models.

Uses

Ailanthone has potent antineoplastic activity against anti-hepatocellular carcinoma (HCC) and has been shown to inhibit Huh7 cancer cell growth through cell cycle arrest and apoptosis in vitro and in vivo.

Definition

ChEBI: Ailanthone is a triterpenoid.

ailanthone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ailanthone manufacturers

Career Henan Chemical Co

Product: ailanthone 981-15-7
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-10

981-15-7, ailanthoneRelated Search:

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ailanthone

Picrasa-3,13(21)-diene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-, (1b,11b,12a)-

(1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione

Δ13-Dehydrochaparrinone

Picrasa-3,13(21)-diene-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-, (1β,11β,12α)-

(1beta,11alpha,12alpha)-1,11,12-trihydroxy-11,20-epoxypicras...

2H-1,11c-(Epoxymethano)phenanthro[10,1-bc]pyran-5,10(3H,6aH)

(1R,2R,3aS,3a1S,6aR,7aS,11S,11aS,11bR)-1,2,11-Trihydroxy-8,11a-dimethyl-3-methylene-2,3,3a,4,7,7a,11,11a-octahydro-1H-1,3a1-(epoxymethano)dibenzo[de,g]chromene-5,10(6aH,11bH)-dione

981-15-7

Diterpenoids