bryonolic acid

Product Name: bryonolic acid
CAS No.: 24480-45-3
Chemical Name: bryonolic acid
Synonyms: Bryolic acid;bryonolic acid;UNII-J7YR6A878I;UNII-J7YR6A878I|||20-epi-Bryonolic acid;3beta-Hydroxy-D-C-friedoolean-8-en-29-oic acid;(20R)-3β-Hydroxy-D:C-friedoolean-8-en-29-oic acid;D:C-Friedoolean-8-en-29-oic acid, 3-hydroxy-, (3beta,20beta)-;26-Norolean-8-en-29-oicacid, 3-hydroxy-13-methyl-, (3b,13a,14b,20b)-;26-Norolean-8-en-29-oic acid, 3-hydroxy-13-methyl-, (3β,13α,14β,20β)-
CBNumber: CB71334730
Molecular Formula: C30H48O3
Formula Weight: 456.71
MOL File: 24480-45-3.mol

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bryonolic acid Property

Melting point:: 303.5 °C
Boiling point:: 553.3±50.0 °C(Predicted)
Density: 1.10±0.1 g/cm3(Predicted)
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 4.79±0.70(Predicted)
color: White to off-white
LogP: 8.404 (est)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom

Product number: CFN98260
Product name: Bryonolicacid
Purity: ≥98%
Packaging: 5mg
Price: $463
Updated: 2021/12/16

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bryonolic acid Chemical Properties,Usage,Production

Uses

Bryonolic acid is an active triterpenoid compound with immunomodulatory, anti-inflammatory, antioxidant and anticancer activities[1][2][3].

Definition

ChEBI: 20-epi-bryonolic acid is a pentacyclic triterpenoid of D:C-friedooleanane-type triterpenoids isolated from the stems of Lagenaria siceraria and roots of Coriaria intermedia and has been found to exhibit antineoplastic activity. It has a role as a metabolite and an antineoplastic agent. It is a pentacyclic triterpenoid and a hydroxy monocarboxylic acid.

in vivo

Bryonolic acid (500 mg/kg; i.p.; once) potently induces HO-1 in a manner dependent on the Nrf2-Keap1 pathway^[3].

Animal Model:	Wild-type and Nrf2-/- mice^[3]
Dosage:	500 mg/kg
Administration:	i.p.; once
Result:	Induced HO-1 in a manner dependent on the Nrf2-Keap1 pathway.

target

NO | NOS | HO-1 | Nrf2 | cAMP | Calcium Channel | Bcl-2/Bax

References

[1] Pornpatsorn Lertphadungkit, et al. Enhanced Production of Bryonolic Acid in Trichosanthes cucumerina L. (Thai Cultivar) Cell Cultures by Elicitors and Their Biological Activities. Plants (Basel). 2020 Jun 2;9(6):709. DOI:10.3390/plants9060709
[2] Farid Khallouki, et al. Bryonolic Acid Blocks Cancer Cell Clonogenicity and Invasiveness through the Inhibition of Fatty Acid: Cholesteryl Ester Formation. Biomedicines. 2018 Feb 12;6(1):21. DOI:10.3390/biomedicines6010021
[3] Tonibelle N Gatbonton-Schwager , et al. Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo. J Nat Prod. 2012 Apr 27;75(4):591-8. DOI:10.1021/np200823p

bryonolic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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bryonolic acid Suppliers

China 58 United States 5 Global 63

Chembest Research Laboratories Limited

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D:C-Friedoolean-8-en-29-oic acid, 3-hydroxy-, (3beta,20beta)-

Bryolic acid

bryonolic acid

26-Norolean-8-en-29-oicacid, 3-hydroxy-13-methyl-, (3b,13a,14b,20b)-

26-Norolean-8-en-29-oic acid, 3-hydroxy-13-methyl-, (3β,13α,14β,20β)-

UNII-J7YR6A878I

UNII-J7YR6A878I|||20-epi-Bryonolic acid

24480-45-3