fulvine

Product Name: fulvine
CAS No.: 6029-87-4
Chemical Name: fulvine
Synonyms: fulvine;Nsc 89932;Brn 1088365;Fulvine (8ci);13-Epicrispatine;20-Norcrotalanan-11,15-dione, 14,19-dihydro-13-hydroxy-, (12-xi,13-xi)-;2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4-hydroxy-3,4,5-trimethyl-, (3R,4S,5S,13aR,13bR)- (9CI)
CBNumber: CB71365589
Molecular Formula: C16H23NO5
Formula Weight: 309.36
MOL File: 6029-87-4.mol

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fulvine Property

Melting point:: 212.5°C
Boiling point:: 449.63°C (rough estimate)
Density: 1.1188 (rough estimate)
refractive index: 1.5500 (estimate)
pka: 13.53±0.60(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PXT0002382
Product name: FULVINE
Purity: 95.00%
Packaging: 5MG
Price: $498.91
Updated: 2021/12/16

Arctom

Product number: CFN00370
Product name: Fulvine
Packaging: 5mg
Price: $488
Updated: 2021/12/16

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fulvine Chemical Properties,Usage,Production

Uses

Fulvine is a pyrrolizidine alkaloid isolated from the seeds of Crotalaria fulva. Fulvine is hepatotoxic and can be used to induce hypertensive pulmonary vascular disease in vivo[1].

Definition

ChEBI: Fulvine is a member of pyrrolizines.

Safety Profile

Poison by intraperitoneal route. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

in vivo

Fulvine can be used in animal modeling to create respiratory disease models^[1]^[2].

Induction of respiratory and liver disease^[1]^[2].

Background

Fulvine on reaching the liver is metabolically converted into a cellular toxin. Some of this toxin is retained in the hepatic cells, and produces necrosis and other cellular changes. Some of the toxin escapes to damage the vascular endothelium in the hepatic veins. This may take the form of endothelial proliferation with the later changes characteristic of veno-occlusion. Carried further, the escaping toxic metabolites reach the pulmonary tissues to produce vascular changes with increased capillary permeability and progressive oedema and cellular changes in the lungs, including the development of the big cells and the accumulation of mast cells^[2].

Specific Modeling Methods

Rat: White SPF and conventional? Male and Female? weighing 50-65 g and 45-60 g^[1]
Administration: 30-45 mg/kg? neutralised aqueous solution by stomach tube? a single dose^[1]
Rat: Male and Female? weighing 40-80 g^[2]
Administration: 50 mg/kg? given by stomach tube? a single dose^[2]

Note

(1)SPF rats and conventional rats were kept separately. All were weighed at least weekly. Rats that died or were killed with coal-gas when ill were examined post mortem. Lungs, liver and other tissues from representative animals were fixed in Hefly’s fluid; paraffin sections were stained with haematoxylin and eosin^[1]
.
Crystalline Fulvine was dissolved in dilute hydrochloric acid, neutralised and diluted to give a 1% solution^[2]
.

Modeling Indicators

Pathology change: The lungs were congested or oedematous and did not collapse when the chest was opened, showing petechiae or small dark red patches. Large often bloodstained, effusions were present in many rats. The liver appeared enlarged, dark red with a brownish tint, slightly granular and rubbery. The heart seemed enlarged; some rats had gastro-intestinal haemorrhage and prominent red lymph-glands. Varying degrees of ascites were present, and the ventral skin was often oedematous^[1]
.
Behavioral observation: Fulvine induced some developed difficulty in breathing and slowing or cessation of growth in rats^[1]
.
Histological analysis: Fulvine induced moderate ascites, well marked fibrous thickening of the central vein walls, endothelial proliferation and some perivascular centrilobular fibrosis with possibly partial venous occlusion^[2]
.

Correlated Product(s): Monocrotaline (HY-N0750); Crispatine

Opposite Product(s): /

References

[1] Schoental R. Rat lung lesions due to Fulvine. J Pathol Bacteriol. 1966 Apr;91(2):629-31. DOI:10.1002/path.1700910246
[2] BARNES JM, et al. LESIONS IN THE LUNGS AND LIVERS OF RATS POISONED WITH THE PYRROLIZIDINE ALKALOID Fulvine AND ITS N-OXIDE. J Pathol Bacteriol. 1964 Oct;88:521-31. DOI:10.1002/path.1700880215
[3] J M Kay, et al.Fulvine and the pulmonary circulation. Thorax DOI:10.1136/thx.26.3.249

fulvine Preparation Products And Raw materials

Raw materials

Preparation Products

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fulvine Suppliers

China 7 United States 2 Global 9

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
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EMMX Biotechnology LLC

Tel: 888-539-0666
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Email: info@emmx.com
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Hubei Baidu Chemical Co., Ltd

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Hubei Guangao Biotechnology Co., Ltd

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Chengdu Peter-like Biotechnology Co., Ltd.

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Biosynth Biological Technology (Suzhou) Co Ltd

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6029-87-4, fulvineRelated Search:

beta-Eudesmol MOSLOFLAVONE alpha-Cyperone (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one Artemether beta-Sitosterol alpha-Terpineol Hydroxyecdysone 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one hydroxygenkwanin MONOCROTALINE fulvine trichodesmine retronecine 3-BUTOXYPYRROLIDINE (4AR,7R,8R,9R,12BR)-8,9-DIHYDROXY-7-ISOPROPYL-8,9-DIMETHYL-2,3,4,4A,8,9,12,12B-OCTAHYDRO-7H-5,11-DIOXA-2A-AZA-CYCLOUNDECA[CD]PENTALENE-6,10-DIONE 2,3,5,7A-TETRAHYDRO-1H-PYRROLIZINE

fulvine

13-Epicrispatine

20-Norcrotalanan-11,15-dione, 14,19-dihydro-13-hydroxy-, (12-xi,13-xi)-

Brn 1088365

Fulvine (8ci)

Nsc 89932

2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4-hydroxy-3,4,5-trimethyl-, (3R,4S,5S,13aR,13bR)- (9CI)

6029-87-4