ChemicalBook > CAS DataBase List > 2-FLUORO-5-METHOXYBENZOIC ACID

2-FLUORO-5-METHOXYBENZOIC ACID

Product Name
2-FLUORO-5-METHOXYBENZOIC ACID
CAS No.
367-83-9
Chemical Name
2-FLUORO-5-METHOXYBENZOIC ACID
Synonyms
BUTTPARK 45\01-62;RARECHEM AL BO 0748;2-Fluoro-5-methoxybenzoicaci;2-FLUORO-5-METHOXYBENZOIC ACID;6-Fluoro-3-methoxybenzoic acid;Benzoic acid, 2-fluoro-5-methoxy-;2-Fluoro-5-(methyloxy)benzoic acid;2-Fluoro-5-Methoxybenzoic acid, 97+%;3-Carboxy-4-fluoroanisole, 6-Fluoro-m-anisic acid
CBNumber
CB7141401
Molecular Formula
C8H7FO3
Formula Weight
170.14
MOL File
367-83-9.mol
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2-FLUORO-5-METHOXYBENZOIC ACID Property

Melting point:
146-150
Boiling point:
302.7±22.0 °C(Predicted)
Density 
1.307
storage temp. 
Sealed in dry,Room Temperature
pka
3.15±0.10(Predicted)
Appearance
White to off-white Solid
CAS DataBase Reference
367-83-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36
Hazard Note 
Irritant
HS Code 
2918999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
F599343
Product name
2-Fluoro-5-methoxybenzoicAcid
Packaging
5g
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
2621-3-25
Product name
2-Fluoro-5-methoxybenzoic acid
Purity
97%
Packaging
1g
Price
$20
Updated
2021/12/16
SynQuest Laboratories
Product number
2621-3-25
Product name
2-Fluoro-5-methoxybenzoic acid
Purity
97%
Packaging
5G
Price
$40
Updated
2021/12/16
Apolloscientific
Product number
PC8208
Product name
2-Fluoro-5-methoxybenzoicacid
Packaging
250mg
Price
$44
Updated
2021/12/16
SynQuest Laboratories
Product number
2621-3-25
Product name
2-Fluoro-5-methoxybenzoic acid
Purity
97%
Packaging
25g
Price
$75
Updated
2021/12/16
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2-FLUORO-5-METHOXYBENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

Class white powder

Uses

2-Fluoro-5-methoxybenzoic acid is used as an organic chemical synthesis intermediate.

Synthesis

459-60-9

124-38-9

367-83-9

The general procedure for the synthesis of 2-fluoro-5-methoxybenzoic acid from 4-fluoroanisole and carbon dioxide was as follows: 1-fluoro-4-methoxybenzene (5 g, 39.6 mmol, 1.0 eq.) and PMDTA (7.56 g, 43.62 mmol, 1.1 eq.) were dissolved in anhydrous THF (100 mL) under nitrogen protection and cooled to -60 °C. A solution of s-BuLi (1.3 M, 36.6 mL, 47.5 mmol, 1.2 eq.) was added slowly over 1 hr. The reaction mixture continued to be stirred at -60 °C for 2 hours. Subsequently, carbon dioxide gas was passed into the solution for 1 hour. After completion of the reaction, the mixture was slowly warmed to room temperature, acidified with 1 M HCl solution and extracted with EtOAc. The organic phases were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: EtOAc/petroleum ether, gradient from 0:1 to 1:1) to afford 2-fluoro-5-methoxybenzoic acid as a yellow solid (5.4 g, 80% yield).LC-MS: m/z 171.1 [M+H]+, 193.0 [M+Na]+. 1H NMR (400 MHz, DMSO-d6) δ. 13.33 (s, 1H), 7.31 (m, 1H), 7.24 (m, 1H), 7.20-7.16 (m, 1H), 3.78 (s, 3H).

References

[1] Journal of Organic Chemistry, 2007, vol. 72, # 4, p. 1271 - 1275
[2] Patent: WO2013/37705, 2013, A2. Location in patent: Page/Page column 61; 62
[3] Patent: WO2004/14856, 2004, A1. Location in patent: Page 21
[4] Tetrahedron Letters, 1992, vol. 33, # 49, p. 7495 - 7498

2-FLUORO-5-METHOXYBENZOIC ACID Preparation Products And Raw materials

Raw materials

4-Fluoroanisole Carbon dioxide Tetrahydrofuran Diethyl ether Sodium hydroxide n-Butyllithium Citric acid

Preparation Products

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View Lastest Price from 2-FLUORO-5-METHOXYBENZOIC ACID manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
2-FLUORO-5-METHOXYBENZOIC ACID 367-83-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Career Henan Chemical Co
Product
2-FLUORO-5-METHOXYBENZOIC ACID 367-83-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

367-83-9, 2-FLUORO-5-METHOXYBENZOIC ACIDRelated Search:

2-FLUORO-6-METHOXYBENZOIC ACID 2-FLUORO-5-(TRIFLUOROMETHOXY)BENZOIC ACID 3-METHOXY-2,4,6-TRIFLUOROBENZOIC ACID 2,6-DIFLUORO-3-METHOXYBENZOIC ACID 2-CHLORO-6-FLUORO-3-METHOXYBENZOIC ACID 4-FLUORO-3-METHOXYBENZOIC ACID 3-FLUORO-2-METHOXYBENZOIC ACID 3-Fluoro-4-methoxybenzoic acid 98%,3-FLUORO-4-METHOXYBENZOIC ACID 4-FLUORO-2-METHOXYBENZOIC ACID,4-Fluoro-2-Methoxybenzoic Acid 2-Methoxy-4-Fluorobenzoic Acid 5-FLUORO-2-METHOXYBENZOIC ACID 6-CHLORO-2-FLUORO-3-METHOXYBENZOIC ACID 2-Fluoro-4-methoxybenzoylchloride 3-Fluoro-5-methoxybenzoic acid 98%,3-FLUORO-5-METHOXYBENZOIC ACID 98 2-FLUORO-3-METHOXYBENZOIC ACID,2-Fluoro-3-methoxybenzoic acid 98% 3-CHLORO-5-FLUORO-4-METHOXYBENZOIC ACID ethyl 2-chloro-6-fluoro-3-methoxybenzoate 2-FLUORO-3,4,5-TRIMETHOXY-BENZOIC ACID METHYL ESTER 2-FLUORO-5-METHOXYBENZOIC ACID

  • 2-FLUORO-5-METHOXYBENZOIC ACID
  • BUTTPARK 45\01-62
  • RARECHEM AL BO 0748
  • 3-Carboxy-4-fluoroanisole, 6-Fluoro-m-anisic acid
  • 2-Fluoro-5-(methyloxy)benzoic acid
  • 6-Fluoro-3-methoxybenzoic acid
  • 2-Fluoro-5-Methoxybenzoic acid, 97+%
  • Benzoic acid, 2-fluoro-5-methoxy-
  • 2-Fluoro-5-methoxybenzoicaci
  • 367-83-9
  • Fluorine series
  • Benzoic acid
  • Acids & Esters
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Fluorine Compounds