2-FLUORO-5-METHOXYBENZOIC ACID
- Product Name
- 2-FLUORO-5-METHOXYBENZOIC ACID
- CAS No.
- 367-83-9
- Chemical Name
- 2-FLUORO-5-METHOXYBENZOIC ACID
- Synonyms
- BUTTPARK 45\01-62;RARECHEM AL BO 0748;2-Fluoro-5-methoxybenzoicaci;2-FLUORO-5-METHOXYBENZOIC ACID;6-Fluoro-3-methoxybenzoic acid;Benzoic acid, 2-fluoro-5-methoxy-;2-Fluoro-5-(methyloxy)benzoic acid;2-Fluoro-5-Methoxybenzoic acid, 97+%;3-Carboxy-4-fluoroanisole, 6-Fluoro-m-anisic acid
- CBNumber
- CB7141401
- Molecular Formula
- C8H7FO3
- Formula Weight
- 170.14
- MOL File
- 367-83-9.mol
2-FLUORO-5-METHOXYBENZOIC ACID Property
- Melting point:
- 146-150
- Boiling point:
- 302.7±22.0 °C(Predicted)
- Density
- 1.307
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.15±0.10(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 367-83-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36
- Hazard Note
- Irritant
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F599343
- Product name
- 2-Fluoro-5-methoxybenzoicAcid
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- HCH0019849
- Product name
- 2-FLUORO-5-METHOXYBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1100.02
- Updated
- 2021/12/16
- Product number
- X4492
- Product name
- 2-Fluoro-5-methoxybenzoicacid
- Packaging
- 10g
- Price
- $401
- Updated
- 2021/12/16
- Product number
- PC8208
- Product name
- 2-Fluoro-5-methoxybenzoicacid
- Packaging
- 5g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 2621-3-25
- Product name
- 2-Fluoro-5-methoxybenzoic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
2-FLUORO-5-METHOXYBENZOIC ACID Chemical Properties,Usage,Production
Chemical Properties
Class white powder
Uses
2-Fluoro-5-methoxybenzoic acid is used as an organic chemical synthesis intermediate.
Synthesis
459-60-9
124-38-9
367-83-9
The general procedure for the synthesis of 2-fluoro-5-methoxybenzoic acid from 4-fluoroanisole and carbon dioxide was as follows: 1-fluoro-4-methoxybenzene (5 g, 39.6 mmol, 1.0 eq.) and PMDTA (7.56 g, 43.62 mmol, 1.1 eq.) were dissolved in anhydrous THF (100 mL) under nitrogen protection and cooled to -60 °C. A solution of s-BuLi (1.3 M, 36.6 mL, 47.5 mmol, 1.2 eq.) was added slowly over 1 hr. The reaction mixture continued to be stirred at -60 °C for 2 hours. Subsequently, carbon dioxide gas was passed into the solution for 1 hour. After completion of the reaction, the mixture was slowly warmed to room temperature, acidified with 1 M HCl solution and extracted with EtOAc. The organic phases were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: EtOAc/petroleum ether, gradient from 0:1 to 1:1) to afford 2-fluoro-5-methoxybenzoic acid as a yellow solid (5.4 g, 80% yield).LC-MS: m/z 171.1 [M+H]+, 193.0 [M+Na]+. 1H NMR (400 MHz, DMSO-d6) δ. 13.33 (s, 1H), 7.31 (m, 1H), 7.24 (m, 1H), 7.20-7.16 (m, 1H), 3.78 (s, 3H).
References
[1] Journal of Organic Chemistry, 2007, vol. 72, # 4, p. 1271 - 1275
[2] Patent: WO2013/37705, 2013, A2. Location in patent: Page/Page column 61; 62
[3] Patent: WO2004/14856, 2004, A1. Location in patent: Page 21
[4] Tetrahedron Letters, 1992, vol. 33, # 49, p. 7495 - 7498
2-FLUORO-5-METHOXYBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-FLUORO-5-METHOXYBENZOIC ACID Suppliers
- Tel
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- Fax
- --
- info@abcr.de
- Country
- Germany
- ProdList
- 6831
- Advantage
- 75
- Tel
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- sales@rarechem.de
- Country
- Germany
- ProdList
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- Advantage
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View Lastest Price from 2-FLUORO-5-METHOXYBENZOIC ACID manufacturers
- Product
- 2-FLUORO-5-METHOXYBENZOIC ACID 367-83-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 2-FLUORO-5-METHOXYBENZOIC ACID 367-83-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09