ChemicalBook > CAS DataBase List > 246TRIHYDROXYCHALCONE

246TRIHYDROXYCHALCONE

Product Name
246TRIHYDROXYCHALCONE
CAS No.
4197-97-1
Chemical Name
246TRIHYDROXYCHALCONE
Synonyms
Joson chalcone;246TRIHYDROXYCHALCONE;3-Phenyl-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one;2-Propen-1-one, 3-phenyl-1-(2,4,6-trihydroxyphenyl)-
CBNumber
CB71419475
Molecular Formula
C15H12O4
Formula Weight
256.25
MOL File
4197-97-1.mol
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246TRIHYDROXYCHALCONE Property

Melting point:
189.9℃
Boiling point:
487.9±45.0 °C(Predicted)
Density 
1.384±0.06 g/cm3(Predicted)
storage temp. 
4°C, away from moisture and light
form 
Solid
pka
6.86±0.40(Predicted)
color 
Light yellow to yellow
InChI
InChI=1S/C15H12O4/c16-11-8-13(18)15(14(19)9-11)12(17)7-6-10-4-2-1-3-5-10/h1-9,16,18-19H
InChIKey
LOYXTWZXLWHMBX-UHFFFAOYSA-N
SMILES
C(C1=C(O)C=C(O)C=C1O)(=O)C=CC1=CC=CC=C1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
PXT0001052
Product name
2',4',6'-TRIHYDROXYCHALCONE
Purity
95.00%
Packaging
5MG
Price
$504.54
Updated
2021/12/16
Crysdot
Product number
CD32001435
Product name
Pinocembrinchalcone
Purity
95+%
Packaging
5mg
Price
$634
Updated
2021/12/16
Arctom
Product number
CFN96919
Product name
Pinocembrinchalcone
Purity
≥98%
Packaging
5mg
Price
$268
Updated
2021/12/16
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246TRIHYDROXYCHALCONE Chemical Properties,Usage,Production

Uses

Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound from Helichrysum Trilineatum. Pinocembrin chalcone facilitates AMP-activated protein kinase (AMPK) activation, improves glucose tolerance, increases muscle FAO and reduces fat accumulation in the liver and skeletal muscles in high-fat diet-induced (HFD) diabetic mice. Pinocembrin chalcone is promising for research of gastric ulcers and diabetes[1][2].

Definition

ChEBI: Pinocembrin chalcone is a member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 2', 4' and 6' respectively. It has a role as a plant metabolite and an antifungal agent. It is functionally related to a trans-chalcone.

in vivo

Pinocembrin chalcone (30 mg/kg, oral gavage, daily for 3 weeks) improves glucose tolerance and fat accumulation through fatty acid oxidation rate increase in skeletal muscle, which is mainly mediated by AMPK activation in HFD-induced diabetic mice[2].

Animal Model:HFD-induced diabetic mice[2]
Dosage:30 mg/kg
Administration:oral gavage, daily for 3 weeks
Result:Reduced the circulating FFA levels and fat accumulation in the liver and muscles by increasing FAO, which improved glucose tolerance in HFD-induced diabetic mice.

References

[1] P D Bremner, et al. Pinocembrin Chalcone: An Antibacterial Compound From Helichrysum Trilineatum. Planta Med. 1998 Dec;64(8):777. DOI:10.1055/s-2006-957585
[2] Shin J, et al. Antidiabetic effects of trihydroxychalcone derivatives via activation of AMP-activated protein kinase[J]. Journal of Industrial and Engineering Chemistry, 2018, 60: 177-184.

246TRIHYDROXYCHALCONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 246TRIHYDROXYCHALCONE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Pinocembrin chalcone 4197-97-1
Price
US $1.00-45.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-08-06

4197-97-1, 246TRIHYDROXYCHALCONERelated Search:

Tris(hydroxymethyl)aminomethane 1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one 4,4'-DIHYDROXY-2-METHOXYCHALCONE Naringin dihydrochalcone 4'-Hydroxy-2,4-dimethoxychalcone Dihydropashanone NARINGENIN CHALCONE Bavachalcone 2'-O-Methylisoliquiritigenin ISOBAVACHALCONE Hydroxysafflor yellow A 2,3,4-Trihydroxybenzophenone 5,7,8-TRIHYDROXYFLAVONE

  • 246TRIHYDROXYCHALCONE
  • 2-Propen-1-one, 3-phenyl-1-(2,4,6-trihydroxyphenyl)-
  • Joson chalcone
  • 3-Phenyl-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one
  • 4197-97-1