PRUNINDIHYDROCHALCONE

Product Name: PRUNINDIHYDROCHALCONE
CAS No.: 4192-90-9
Chemical Name: PRUNINDIHYDROCHALCONE
Synonyms: trilobin;Trilobatin;p-Phlorizin;p-Phloridzin;Trilobatin-RM;TRILOBATIN(SH);TRILOBATIN(AS) 10mg;PRUNINDIHYDROCHALCONE;Phloretin 4'-glucoside;Trilobatin, 10 mM in DMSO
CBNumber: CB71426381
Molecular Formula: C21H24O10
Formula Weight: 436.41
MOL File: 4192-90-9.mol

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PRUNINDIHYDROCHALCONE Property

Melting point:: 170-173 °C
Boiling point:: 787.9±60.0 °C(Predicted)
Density: 1.555±0.06 g/cm3(Predicted)
FEMA: 4674 | TRILOBATIN
storage temp.: 4°C, protect from light
solubility: DMF: 20 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 0.1 mg/ml
form: A crystalline solid
pka: 6.85±0.40(Predicted)
color: White to off-white
JECFA Number: 2171
InChIKey: GSTCPEBQYSOEHV-LKLLPNDVNA-N
SMILES: C(C1C(=CC(O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=CC=1O)O)(=O)CCC1C=CC(O)=CC=1 |&1:6,7,8,10,12,r|
LogP: 1.36

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Safety

HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T4092
Product name: Trilobatin
Packaging: 100MG
Price: $178
Updated: 2025/07/31

Cayman Chemical

Product number: 25837
Product name: Trilobatin
Packaging: 1mg
Price: $66
Updated: 2024/03/01

Cayman Chemical

Product number: 25837
Product name: Trilobatin
Packaging: 10mg
Price: $323
Updated: 2024/03/01

Cayman Chemical

Product number: 25837
Product name: Trilobatin
Packaging: 5mg
Price: $242
Updated: 2024/03/01

Usbiological

Product number: 301076
Product name: Trilobatin
Packaging: 20mg
Price: $390
Updated: 2021/12/16

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PRUNINDIHYDROCHALCONE Chemical Properties,Usage,Production

Chemical Properties

Soluble in organic solvents such as methanol, ethanol, and DMSO.

Uses

Trilobatin, a natural sweetener derived from?Lithocarpus polystachyus?Rehd[1], Trilobatin?is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope[2]. Neuroprotective effects[1]. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells[3].

Definition

ChEBI: Trilobatin is an aryl beta-D-glucoside that is phloretin attached to a beta-D-glucopyranosyl residue at position 4' via a glycosidic linkage. It is isolated from the leaves of the Chinese sweet tea Lithocarpus polystachyus and exhibits significant anti-hyperglycemic, anti-oxidative and anti-inflammatory properties. It has a role as an anti-inflammatory agent, a sweetening agent, an antioxidant and a plant metabolite. It is an aryl beta-D-glucoside, a member of dihydrochalcones and a monosaccharide derivative. It is functionally related to a phloretin.

IC 50

HIV-1; SGLT1; SGLT2

References

[1] Gao J, et al. Trilobatin?Protects Against Oxidative Injury in Neuronal PC12 Cells Through Regulating Mitochondrial ROS Homeostasis Mediated by AMPK/Nrf2/Sirt3 Signaling Pathway. Front Mol Neurosci.?2018 Jul 30;11:267. DOI:10.3389/fnmol.2018.00267
[2] Yin S,?et al. Trilobatin?as an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. FEBS Lett.?2018 Jul;592(13):2361-2377. DOI:10.1002/1873-3468.13113

PRUNINDIHYDROCHALCONE Preparation Products And Raw materials

Raw materials

Preparation Products

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PRUNINDIHYDROCHALCONE Suppliers

China 162 United Kingdom 1 United States 13 Global 176

Nanjing Duolong Bio-tech Co.,Ltd.

Tel: 18905173768
Fax: 025-83263139
Email: 52513593@qq.com
Country: China
ProdList: 2331
Advantage: 50

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 18108052721
Email: 2850505130@qq.com
Country: China
ProdList: 5167
Advantage: 58

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Chengdu Herbpurify Co.Ltd.

Tel: 2355253622; 18981954830
Fax: 086-28-85377358
Email: 2355253622@qq.com;
Country: China
ProdList: 1103
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9979
Advantage: 58

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View Lastest Price from PRUNINDIHYDROCHALCONE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: PRUNINDIHYDROCHALCONE 4192-90-9
Price: US $1.00-50.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-07-31

Shanghai Standard Technology Co., Ltd.

Product: Trilobatin 4192-90-9
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-05-08

Career Henan Chemical Co

Product: PRUNINDIHYDROCHALCONE 4192-90-9
Price: US $5.50/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 10g,100g,1kg
Release date: 2020-01-09

4192-90-9, PRUNINDIHYDROCHALCONERelated Search:

ISOBAVACHALCONE Dihydropashanone Bavachalcone Naringin dihydrochalcone 2'-O-Methylisoliquiritigenin 4,4'-DIHYDROXY-2-METHOXYCHALCONE 4'-Hydroxy-2,4-dimethoxychalcone Hydroxysafflor yellow A NARINGENIN CHALCONE 1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one Phlorizin Phloretin

PRUNINDIHYDROCHALCONE

1-[4-(β-D-Glucopyranosyloxy)-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone

Phloretin 4'-glucoside

p-Phloridzin

p-Phlorizin

Trilobatin

TRILOBATIN(SH)

Trilobatin, 98%, from leaf of strigose hydrangea

1-[2,6-dihydroxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one

1-Propanone, 1-[4-(β-D-glucopyranosyloxy)-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-

1-(2,6-Dihydroxy-4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3-(4-hydroxyphenyl)propan-1-one

trilobin

TRILOBATIN(AS) 10mg

Trilobatin-RM

Trilobatin, 10 mM in DMSO

3,5-dihydroxy-4-[3-(4-hydroxyphenyl)propanoyl]phenyl beta-D-glucopyranoside

4192-90-9