ChemicalBook > CAS DataBase List > 5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID

5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID

Product Name
5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID
CAS No.
10406-06-1
Chemical Name
5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID
Synonyms
RARECHEM AL BE 0374;5-BroMo-3-indolecarboxylic Acid;5-BROMOINDOLE-3-CARBOXYLIC ACID;5-Bromoindole-3-carboxylicAcid>5-Bromoindole-3-carboxylicacid,97%;5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID;1H-Indole-3-carboxylic acid, 5-broMo-
CBNumber
CB7142938
Molecular Formula
C9H6BrNO2
Formula Weight
240.05
MOL File
10406-06-1.mol
More
Less

5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID Property

Melting point:
238-240 °C (decomp)
Boiling point:
240°C(lit.)
Density 
1.838±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
3.68±0.30(Predicted)
form 
Solid
color 
White to Light yellow
InChI
InChI=1S/C9H6BrNO2/c10-5-1-2-8-6(3-5)7(4-11-8)9(12)13/h1-4,11H,(H,12,13)
InChIKey
JVZMBSGNSAHFCY-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(Br)C=C2)C(C(O)=O)=C1
CAS DataBase Reference
10406-06-1(CAS DataBase Reference)
More
Less

Safety

HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
B4790
Product name
5-Bromoindole-3-carboxylic Acid
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$126
Updated
2025/07/31
TCI Chemical
Product number
B4790
Product name
5-Bromoindole-3-carboxylic Acid
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$504
Updated
2025/07/31
TRC
Product number
B694523
Product name
5-Bromo-1H-indole-3-carboxylicAcid
Packaging
10mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB33252
Product name
5-Bromo-1H-indole-3-carboxylic acid
Packaging
250mg
Price
$132.5
Updated
2021/12/16
Apolloscientific
Product number
OR480712
Product name
5-Bromo-1H-Indole-3-Carboxylic Acid
Packaging
5g
Price
$189
Updated
2021/12/16
More
Less

5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

5-Bromo-1H-indole-3-carboxylic Acid is a useful intermediate used in the synthesis of indole derivatives that functions as inhibitors for the vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase.

Synthesis

10075-50-0

124-38-9

10406-06-1

Lithium tert-butoxide (LiOtBu, 160 mg, 2.00 mmol) and 5-bromoindole (23.4 mg, 0.4 mmol) were added to a dry two-neck flask. The reaction vessel was evacuated and filled with carbon dioxide gas. Subsequently, N,N-dimethylformamide (DMF, 2 mL) was added and the mixture was stirred and reacted at 100 °C for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature, the reaction was carefully quenched with 2N hydrochloric acid solution and extracted with ethyl acetate (5 x 5 mL). The organic phases were combined, washed sequentially with water (2 x 5 mL) and saturated saline (1 x 5 mL) and dried over anhydrous magnesium sulfate. The dried organic phases were concentrated under reduced pressure and the residue was purified by preparative thin layer chromatography (Spreader: hexane/acetone=1:1, v/v) to afford the target compound 5-bromo-1H-indole-3-carboxylic acid (153.0 mg, 95% yield) as a white solid.

References

[1] Organic Letters, 2012, vol. 14, # 20, p. 5326 - 5329,4
[2] Heterocycles, 2015, vol. 90, # 2, p. 1196 - 1204

5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID Suppliers

Americas 1 China 140 Europe 1 Germany 1 India 3 Japan 1 Ukraine 2 United Kingdom 3 United States 17 Global 169
Shanghai Union Medical Technology Co. Ltd.
Tel
13120563767
Fax
15669989863
Email
chemchen925@outlook.com
Country
China
ProdList
987
Advantage
58
Shandong utilizing biological technology co., LTD
Tel
15966937598
Fax
3407640895 3071519937
Email
3407650895@qq.com
Country
China
ProdList
2274
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Chembon Pharmaceutical Co., Ltd.
Tel
028-84252981
Fax
+86-28-84252965
Email
sales@chembon.com.cn
Country
China
ProdList
850
Advantage
64
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Wuhan Arike Technology Co., Ltd.
Tel
027- 51832457 94518350
Fax
E-Mail Inquiry
Country
China
ProdList
746
Advantage
62
Tongchuang Pharma(Suzhou). Co., Ltd.
Tel
0512-63263366 18912765016
Fax
0512-6326 3366
Email
tongtf110@sina.com
Country
China
ProdList
993
Advantage
62
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4000
Advantage
55
Wuhan ariel chemical Co., LTD.
Tel
18986259541
Fax
027-87840182
Email
sales@3stc.com
Country
China
ProdList
3764
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
Shanghai potentpharm CO.,Ltd
Tel
13524892556
Fax
(86) 21 51969655， QQ： 263541193
Email
sales-cn@potentpharm.com
Country
China
ProdList
1011
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
JIANGYIN CANAL PHARMTECH CO.,LIMITED.
Tel
+86-18921203887
Fax
+86-0510-86319635 ; QQ:1622023101
Email
sales@canalpharm.net
Country
China
ProdList
288
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9979
Advantage
55
Taizhou Tongxin Bio-Tech Co., Ltd
Tel
0523-86818997 18652728585
Email
sales@allyrise.com
Country
China
ProdList
2966
Advantage
60
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Changzhou Qinuo Chemical Co., Ltd.Co., Ltd.
Tel
0519-0519-83812535
Email
sales@qinuochem.com
Country
China
ProdList
287
Advantage
60
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5674
Advantage
50
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Bellen Chemistry Co., Ltd.
Tel
010-60400365-8001 15910885229
Fax
010-60400361
Email
service@bellenchem.com
Country
China
ProdList
4514
Advantage
60
Quzhou Rundong Chemical (Technology) Co.
Tel
0570-8789886 18892685668
Fax
0570-8789985
Email
info@rundongchemical.com
Country
China
ProdList
4053
Advantage
60
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
JW & Y Pharmlab Co., Ltd.
Tel
021-64340559 13651849907;
Fax
021- 64345308
Email
xinyu_shi@jwypharmlab.com.cn
Country
China
ProdList
12000
Advantage
58
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.
Tel
027-65388397 18164111589
Fax
027-65388397
Email
3321478047@qq.com
Country
China
ProdList
2007
Advantage
55
Tianjin Being Technology Co., Ltd.
Tel
18622939839
Fax
QQ:343281693
Email
tjby921@163.com
Country
China
ProdList
884
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12475
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
10110
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Nanjing KaiMubo Pharmaceutical Co., Ltd.
Tel
025-66162170
Fax
025-66162170
Country
China
ProdList
7181
Advantage
55
Shanghai CR Corporation Limited
Tel
13062833949; 4006653949 4006653949
Fax
QQ: 2136646215
Email
fred.wen@crcorporation.cn
Country
China
ProdList
9756
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Nanijing m&m biotechnology Co. ,Ltd.
Tel
025-87782433 18021532344
Fax
025-87782433
Email
1345332203@qq.com
Country
China
ProdList
4134
Advantage
58
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
Country
China
ProdList
9998
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Zhengzhou Ruke Biological Co., Ltd.
Tel
15981811963
Fax
QQ：1410472904
Email
1410472904@qq.com
Country
China
ProdList
5825
Advantage
58
Henan Alfachem Co.,Ltd.
Tel
0371-55051623 18137891487
Fax
QQ：2853979817
Email
2853979817@qq.com
Country
China
ProdList
9988
Advantage
58
Chengdu AiQun Pharmaceutical Technology Co., Ltd.
Tel
028-82393420 18108156287
Fax
028-82393420
Email
2982653826@qq.com
Country
China
ProdList
560
Advantage
58
More
Less

View Lastest Price from 5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co
Product
5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID 10406-06-1
Price
US $8.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10tons
Release date
2018-12-25

10406-06-1, 5-BROMO-1H-INDOLE-3-CARBOXYLIC ACIDRelated Search:

5-Bromoindole-3-carboxaldehyde 7024 6-BROMO-1H-INDOLE-3-CARBOXYLIC ACID,6-BROMO-1H-INDOLE-3-CARBOXYLIC ACID 4-BROMOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-BROMO-1H-INDOLE-2-CARBOXYLIC ACID 4-bromo-1h-indole-3-carboxylic acid 5-BROMO-1H-INDOLE-2-CARBOXYLIC ACID RARECHEM AL BI 0374 5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER 6-BROMO-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER 7-BROMO-1H-INDOLE-3-CARBOXYLIC ACID 6-BROMO-1H-INDOLE-2-CARBOXYLIC ACID 3-BROMOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Ethyl 6-bromoindole-2-carboxylate 7-BROMO-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER 7-BROMO-1H-INDOLE-2-CARBOXYLIC ACID Ethyl 5-Bromoindole-2-carboxylate 3-BROMO-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER 5-Bromoindole

  • RARECHEM AL BE 0374
  • 5-BroMo-3-indolecarboxylic Acid
  • 1H-Indole-3-carboxylic acid, 5-broMo-
  • 5-BROMOINDOLE-3-CARBOXYLIC ACID
  • 5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID
  • 5-Bromoindole-3-carboxylicAcid&gt
  • 5-Bromoindole-3-carboxylicacid,97%
  • 10406-06-1
  • pharmacetical
  • Indole