7-AMINOACTINOMYCIN D

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7-AMINOACTINOMYCIN D

Product Name: 7-AMINOACTINOMYCIN D
CAS No.: 7240-37-1
Chemical Name: 7-AMINOACTINOMYCIN D
Synonyms: 7-AAD;7-ADD;7-AMINO-AMD;7-AAD/CH85402;7-ACTINOMYCIN C;7-AMINOACTINOMYCIN;7-AMINODACTINOMYCIN;7-AMINOACTINOMYCIN D;7-AMINOACTINOMYCIN C1;ACTINOMYCIN D, 7-AMINO
CBNumber: CB7145520
Molecular Formula: C62H87N13O16
Formula Weight: 1270.43
MOL File: 7240-37-1.mol

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7-AMINOACTINOMYCIN D Property

Melting point:: 252～253℃
Boiling point:: 1400.8±65.0 °C(Predicted)
Density: 1.44
Flash point:: 801℃
storage temp.: -20°C
solubility: chloroform: 1 mg/mL, clear, red
form: powder
pka: 8.90±0.70(Predicted)
color: red to dark purple
BRN: 5915844
Stability:: Stable for 1 year from date of purchase as supplied. Solutions should be made fresh daily.

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Safety

Hazard Codes: T+,T
Risk Statements: 26/27/28-36/37/38
Safety Statements: 26-28-36/37-45
RIDADR: UN 3462 6.1/PG 2
WGK Germany: 3
RTECS: AU1579000
F: 8-10-21
HazardClass: 6.1(a)
PackingGroup: II
HS Code: 29419090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A9400
Product name: 7-Aminoactinomycin D
Purity: ~97% (HPLC), powder
Packaging: 1mg
Price: $118.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 129935
Product name: Actinomycin D, 7-Amino-
Packaging: 1mg
Price: $173.9
Updated: 2021/12/16

Cayman Chemical

Product number: 11397
Product name: 7-Aminoactinomycin D
Purity: ≥95%
Packaging: 1mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 11397
Product name: 7-Aminoactinomycin D
Purity: ≥95%
Packaging: 5mg
Price: $433
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1633
Product name: 7-Aminoactinomycin D
Purity: 1 mg/mL
Packaging: 1ml
Price: $340
Updated: 2024/03/01

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7-AMINOACTINOMYCIN D Chemical Properties,Usage,Production

Description

7-Aminoactinomycin D (7-AAD) is a fluorescent DNA dye that is commonly used for the detection or exclusion of non-viable cells in flow cytometric analysis, as it is generally excluded by live cells. It displays excitation spectra of 488, 546, and 578 nm and an emission spectrum of 650 nm. As 7-AAD is detected in the far red range of the spectrum, it exhibits minimal spectral overlap with commonly used probes, therefore it can be used in conjunction with probes such as FITC. 7-AAD has been used to evaluate apoptosis and cell-mediated cytotoxicity and to stain DNA in cells that have been fixed and permeabilized by a variety of methods.

Chemical Properties

Purple powder

Uses

Fluorescent DNA stain. A featured product for Apoptosis research.

Uses

7-Aminoactinomycin D is a fluorescent DNA dye for apoptosis and flow cytomtery studies.

Definition

ChEBI: 7-aminoactinomycin D is a chromopeptide. It has a role as a fluorochrome.

General Description

Free form:
Excitation: 503 nm (0.01 M phosphate buffer, pH 7.0 containing 0.1 mM EDTA); 550 nm
Emission: 675 nm (0.01 M phosphate buffer, pH 7.0 containing 0.1 mM EDTA); 672 nm
DNA Complex:
Excitation: 543 nm; 555 nm
Emission: 655 nm; 665 nm

Biochem/physiol Actions

Primary Targetleukemias and sarcomas

storage

Store at -20°C

References

1) Telieps?et al.?(2013)?Cellular-FLIP, Raji isoform (c-FLIP R) modulates cell death induction upon T-cell activation and infection, Eur. J. Immunol. 43 1499 2) Schmid?et al.?(2007)?Live-cell assay for detection of apoptosis by dual-laser flow cytometry using Hoechst 33342 and 7-amino-actinomycin D, Nat. Protoc.?2?187 3) Toba?et al.?(2000) Cell kinetic study of normal human bone marrow hematopoiesis and acute leukemia using 7AAD/PY, Eur.J.Haematol. 64 10 4) Lecoeur?et al.?(1997)?Strategies for phenotyping apoptotic peripheral human lymphocytes comparing ISNT, annexin-V and 7-AAD cytofluorometric staining methods, J. Immunol. Methods?209?111 5) Su?et al.?(1996)?Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defect, J. Immunol.?156?4198

7-AMINOACTINOMYCIN D Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7-AMINOACTINOMYCIN D manufacturers

Career Henan Chemical Co

Product: 7-AMINOACTINOMYCIN D 7240-37-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2019-12-30

7240-37-1, 7-AMINOACTINOMYCIN DRelated Search:

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7-AAD

7-AMINODACTINOMYCIN

7-AMINOACTINOMYCIN

7-AMINOACTINOMYCIN C1

7-AMINOACTINOMYCIN D

7-AMINO-AMD

7-ADD

7-ACTINOMYCIN C

ACTINOMYCIN D, 7-AMINO

7-AAD/CH85402

7-AAD, 7-AMinoactinoMycin D

7-AAD [7-Aminoactinomycin D] *CAS 7240-37-1*

Actinomycin D, 7-Amino- - CAS 7240-37-1 - Calbiochem

7-AMINOACTINOMYCIN D USP/EP/BP

7-Aminoactinomycin D (7-AAD), Fluorescent DNA dye

7240-37-1

C62H87N13O16

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