ChemicalBook > CAS DataBase List > N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine

N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine

Product Name
N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine
CAS No.
231278-20-9
Chemical Name
N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine
Synonyms
in-4-amine;)-6-iodoquinazoL;Lapatinib Impurity 25;Lapatinib Intermediate 2;N-(3-Chloro-4-((3-fluorobenzyl);N-[3-Chloro-4-(3-fluorobenzyloxy);N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-;N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquin;[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl](6-iodoquinazol;6-Iodo-4-[3-chloro-4-(3-fluorobenzyloxy)anilino]quinazoline
CBNumber
CB71456991
Molecular Formula
C21H14ClFIN3O
Formula Weight
505.71
MOL File
231278-20-9.mol
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N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine Property

Melting point:
222-224°C
Boiling point:
581.3±50.0 °C(Predicted)
Density 
1.691±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
pka
5.04±0.50(Predicted)
form 
Solid
color 
Yellow to Dark Yellow
Water Solubility 
Slightly soluble in water.
Sensitive 
Light Sensitive
InChI
InChI=1S/C21H14ClFIN3O/c22-18-10-16(5-7-20(18)28-11-13-2-1-3-14(23)8-13)27-21-17-9-15(24)4-6-19(17)25-12-26-21/h1-10,12H,11H2,(H,25,26,27)
InChIKey
UHFPFDMMKYQMLC-UHFFFAOYSA-N
SMILES
N1=C2C(C=C(I)C=C2)=C(NC2=CC=C(OCC3=CC=CC(F)=C3)C(Cl)=C2)N=C1
CAS DataBase Reference
231278-20-9(CAS DataBase Reference)
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Safety

HS Code 
2933.59.8000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2965
Product name
4-[3-Chloro-4-(3-fluorobenzyloxy)phenylamino]-6-iodoquinazoline
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$50
Updated
2025/07/31
TCI Chemical
Product number
C2965
Product name
4-[3-Chloro-4-(3-fluorobenzyloxy)phenylamino]-6-iodoquinazoline
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$146
Updated
2025/07/31
TRC
Product number
B807825
Product name
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodo-4-quinazolinamine
Packaging
500mg
Price
$55
Updated
2021/12/16
AK Scientific
Product number
J98640
Product name
N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine
Packaging
5g
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
090573
Product name
N-(3-Chloro-4-((3-fluorobenzyl)oxy)-phenyl)-6-iodoquinazolin-4-amine
Purity
97%
Packaging
5g
Price
$75
Updated
2021/12/16
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N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine Chemical Properties,Usage,Production

Description

N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodo-quinazolin-4-amine is a quinazoline derivative that has also been used in the design, synthesis and biological evaluation of quinazoline-phosphoramidate mustard conjugates as anticancer drugs.

Chemical Properties

Yellow Solid

Uses

Lapatinib intermediate

Uses

4-[3-Chloro-4-(3-fluorobenzyloxy)phenylamino]-6-iodoquinazoline is used as an organic chemical synthesis intermediate.

N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine Suppliers

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View Lastest Price from N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine manufacturers

Jinan Ruitong Biotech Co., Ltd.
Product
N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine 231278-20-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2025-08-27
WUHAN FORTUNA CHEMICAL CO., LTD
Product
N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine 231278-20-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
200kg
Release date
2021-08-25
Nanjing Fred Technology Co., Ltd
Product
N-{3-chloro-4-[(3-fluorobenzyl)-oxy]phenyl}-6-iodoquinazolin-4-amine 231278-20-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-29

231278-20-9, N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amineRelated Search:

Diphenyldiethoxysilane 4-Methoxybenzylchloride Sulfaquinoxaline Bis(2-ethylhexyl)amine Quinazoline Diphenyldimethoxysilane Triallylamine Triethanolamine Quinoxaline Diphenyl ether Triethylamine PHENYL VALERATE 4-Methoxyphenylacetone 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone PHENYL RESIN 3-Chloro-4-(3-fluorobenzyloxy)aniline Lapatinib Phenylacetic acid

  • N-[3-Chloro-4-(3-fluorobenzyloxy)-phenyl]-6-iodoquinazolin-4-amine
  • N-{3-Chloro-4-[(3-fluorophenyl)-methoxy]-phenyl}-6-iodo-4-quinazolinamine
  • 6-Iodo-4-[3-chloro-4-(3-fluorobenzyloxy)anilino]quinazoline
  • N-[3-Chloro-4-(3-fluorobenzyloxy) phenyl]-6-iodoquinazolin-5-amine
  • 4-[3-Chloro-4-(3-fluorobenzyloxy)phenylamino]-6-iodoquinazolin
  • N-(3-Chloro-4-((3-fluorobenzyl)
  • Lapatinib Impurity 25
  • N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodo-4-quinazolinamine
  • Lapatinib Intermediate 2
  • [3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl](6-iodoquinazol
  • N-{3-chloro-4-[(3-fluorophenyl)Methoxy]phenyl}-6-iodoquinazolin-4-aMine
  • 4-[3-Chloro-4-(3-fluorobenzyloxy)phenylaMino]-6-iodoquinazoline, 97%
  • N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-iodoquinazolin-4-aMine
  • [3-Chloro-4-(3-fluoro-benzyloxy)-phenyl]-(6-iodo-quinazolin-4-yl)-aMine
  • N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-
  • N-(4-(3-Fluorobenzoyloxy)-3-chlorophenyl)-6-iodo quinazolin-4-aMine
  • N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazoline-4-aMine
  • N-[3-Chloro-4-(3-fluorobenzyloxy)-phenyl]-6-iodoquinazolin-4-aMi
  • N-[3-chloro -4-(3- fluorinebenzyl)phenyl]-6-iodinequinazolin -4-aMine
  • 4-[3-Chloro-4-(3-fluorobenzyloxy)phenylamino]-6-iodoquinazoline &gt
  • )-6-iodoquinazoL
  • in-4-amine
  • 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodo-
  • 4-[3-Chloro-4-(3-fluorobenzyloxy)phenylamino]-6-iodoquinazoline,97%
  • N-[3-Chloro-4-(3-fluorobenzyloxy)
  • 4-[3-Chloro-4-(3-fluorobenzyloxy)anilino]-6-iodoquinazoline
  • N-[3-Chloro-4-(3-Fluorobenzyloxy)-Phenyl]-6-Iodoquinazolin-4-Amine(For export only)
  • N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquin
  • N-[3-Chloro-4-[(3-fluorophenyl)oxy]-phenyl]iodo-4-quinazolinamine
  • N-[3-Chloro-4-(3-fluorobenzyloxy)-phenyl]-6-iodoquinazolin-4...
  • N - [3-chloro-4 - (3-fluorobenzyloxy) phenyl] - 6-iodoquinozoline-5-amine
  • 3-Chloro-4-(3-fluorobenzyloxy)-phenyl]-6-iodoquinazolin -4-amine
  • 4-[3-Chloro-4-(3-fluorobenzyloxy)phenylamino]-6-iodoquinazoline
  • 231278-20-9
  • 31278-20-9
  • 291278-20-9
  • C21H14ClFIN3O
  • Lapatinib
  • Intermediates
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Pharmaceutical intermediate
  • Various Intermediates
  • Intermediate of lapatinib ditosylate