Methyl 1,3-benzodioxole-4-carboxylate
- Product Name
- Methyl 1,3-benzodioxole-4-carboxylate
- CAS No.
- 33842-16-9
- Chemical Name
- Methyl 1,3-benzodioxole-4-carboxylate
- Synonyms
- Methyl 1,3-Benzodioxole-4-carboxylate;methyl benzo[d][1,3]dioxole-4-carboxylate;Methyl 2H-benzo[d]1,3-dioxolene-4-carboxylate;Methyl 1,3-Benzodioxole-4-Carboxylate(WX618073);1,3-Benzodioxole-4-carboxylic acid, methyl ester;Benzo[1,3]dioxole-4-carboxylic acid methyl ester
- CBNumber
- CB71459659
- Molecular Formula
- C9H8O4
- Formula Weight
- 180.16
- MOL File
- 33842-16-9.mol
Methyl 1,3-benzodioxole-4-carboxylate Property
- Melting point:
- 55-56 °C
- Boiling point:
- 280.1±19.0 °C(Predicted)
- Density
- 1.300±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to brown Solid
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M335240
- Product name
- Methyl1,3-benzodioxole-4-carboxylate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M335240
- Product name
- Methyl1,3-benzodioxole-4-carboxylate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR951639
- Product name
- Methyl1,3-benzodioxole-4-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- Z4614
- Product name
- Methylbenzo[d][1,3]dioxole-4-carboxylate
- Packaging
- 1g
- Price
- $131
- Updated
- 2021/12/16
- Product number
- 2H23-1-0V
- Product name
- Methyl1,3-benzodioxole-4-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $184
- Updated
- 2021/12/16
Methyl 1,3-benzodioxole-4-carboxylate Chemical Properties,Usage,Production
Synthesis
2411-83-8
74-95-3
33842-16-9
General procedure for the synthesis of methyl benzo[d][1,3]meso-dioxole-4-carboxylate from methyl 2,3-dihydroxybenzoate and dibromomethane: 6.0 g (0.036 mol) of methyl 2,3-dihydroxybenzoate and cesium carbonate (0.54 mol) were dissolved in 50 mL of N,N-dimethylformamide (DMF). 11.5 mL of dibromomethane (0.54 mol) was added slowly and dropwise at room temperature. After the dropwise addition, the temperature of the reaction system was raised to 110 °C and the reaction was maintained at this temperature for 3 hours. After completion of the reaction, the reaction was cooled to room temperature, stopped and filtered. Equal volumes of water and ethyl acetate were added to the filtrate for liquid-liquid separation. The aqueous phase was extracted twice with ethyl acetate, and all organic phases were combined and washed with water and saturated saline in that order. The organic phase was dried with anhydrous sodium sulfate for 8 minutes. The desiccant was removed by filtration, the solvent was removed by evaporation under reduced pressure and the residue was purified by silica gel column chromatography. Petroleum ether: ethyl acetate (6:1, v/v) was used as eluent to collect the target component, and 5.2 g of white solid product was obtained after evaporation under reduced pressure in 81.2% yield.
References
[1] Patent: CN103804341, 2018, B. Location in patent: Paragraph 0064; 0068; 0069
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 4, p. 871 - 887
[3] Patent: US2004/34046, 2004, A1
[4] Patent: WO2004/4732, 2004, A1. Location in patent: Page/Page column 65-66
[5] Patent: WO2005/34939, 2005, A1. Location in patent: Page/Page column 76
Methyl 1,3-benzodioxole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 1,3-benzodioxole-4-carboxylate manufacturers
- Product
- Methyl 1,3-benzodioxole-4-carboxylate 33842-16-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-15