ChemicalBook > CAS DataBase List > 3-(Trifluoromethyl)-2-pyridinecarbonitrile
3-(Trifluoromethyl)-2-pyridinecarbonitrile
- Product Name
- 3-(Trifluoromethyl)-2-pyridinecarbonitrile
- CAS No.
- 406933-21-9
- Chemical Name
- 3-(Trifluoromethyl)-2-pyridinecarbonitrile
- Synonyms
- 3-Trifluoromethylpicolinonitrile;2-Cyano-3-trifluoromethylpyridine;3-trifluoromethyl-2-pyridinitrile;3-(trifluoroMethyl)-2-pyridinecarbonitrile;2-Pyridinecarbonitrile, 3-(trifluoromethyl)-;3-(Trifluoromethyl)-2-picolinonitrile, 2-Cyano-3-(trifluoromethyl)pyridine;3-Trifluoromethyl-2-pyridinecarbonitrile 2-Cyano-3-trifluoromethylpyridine
- CBNumber
- CB71471129
- Molecular Formula
- C7H3F3N2
- Formula Weight
- 172.11
- MOL File
- 406933-21-9.mol
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3-(Trifluoromethyl)-2-pyridinecarbonitrile Property
- Boiling point:
- 241℃
- Density
- 1.37
- Flash point:
- 99℃
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -2.75±0.10(Predicted)
- Appearance
- Colorless to off-white Solid-liquid mixture
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Safety
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- C991748
- Product name
- 2-Cyano-3-Trifluoromethylpyridine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
TRC
- Product number
- C991748
- Product name
- 2-Cyano-3-Trifluoromethylpyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC54380
- Product name
- 2-Cyano-3-trifluoromethylpyridine
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H37-3-Z8
- Product name
- 3-(Trifluoromethyl)pyridine-2-carbonitrile
- Purity
- 98%
- Packaging
- 5G
- Price
- $138
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 127074
- Product name
- 3-(Trifluoromethyl)pyridine-2-carbonitrile
- Purity
- >95%
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
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3-(Trifluoromethyl)-2-pyridinecarbonitrile Chemical Properties,Usage,Production
Synthesis
65753-47-1
406933-21-9
The general procedure for the synthesis of 3-trifluoromethyl-2-pyridinecarbonitrile from 2-chloro-3-trifluoromethylpyridine was as follows: 2-chloro-3-trifluoromethylpyridine (5 g, 28.9 mmol) was dissolved in dimethylformamide (40 ml) under the protection of nitrogen, and zinc cyanide (2 g, 17.4 mmol), zinc powder (85 mg, 1.3 mmol) and 1,1'- diphenylphosphine ferrocene palladium(II) dichloride complex with dichloromethane (460 mg, 0.63 mmol). The reaction mixture was heated to reflux and kept for 4 hours. After completion of the reaction, it was cooled to room temperature, diluted with ethyl acetate and washed with saturated saline. The aqueous phase was back-extracted with ethyl acetate, the organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by fast column chromatography (eluent: hexane solution of 20% ethyl acetate) afforded 3-trifluoromethyl-2-pyridinecarbonitrile (4.67 g, 98% yield) as a yellow oil.1H NMR (400 MHz, CDCl3) δ 8.59 (1H, dd, J=4.4,1.2 Hz), 8.05-8.02 (1H, m), 7.40- 7.37 (1H, m) ppm.
References
[1] Patent: WO2004/74290, 2004, A1. Location in patent: Page 45
[2] Patent: US2004/53929, 2004, A1
3-(Trifluoromethyl)-2-pyridinecarbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(Trifluoromethyl)-2-pyridinecarbonitrile manufacturers
Shanghai Rlavie Technology Co ltd
- Product
- 3-Trifluoromethyl-pyridine-2-carbonitrile 406933-21-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2021-11-21
Career Henan Chemical Co
- Product
- 2-Cyano-3-trifluoromethylpyridine 406933-21-9
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-03
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