ChemicalBook > CAS DataBase List > (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE

Product Name
(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE
CAS No.
189028-95-3
Chemical Name
(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE
Synonyms
(4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one;ZT-5;idin-2-one;Ezetimibe-003;Ezetimibe INT A;(S)-3-((S)-5-(4-FL;-5-(4-Fluorophenyl);-5-hydroxypentanoyl);)-5-hydroxypentanoyL;Ezetimibe Impurity 45
CBNumber
CB71473325
Molecular Formula
C20H20FNO4
Formula Weight
357.38
MOL File
189028-95-3.mol
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(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Property

Boiling point:
572.7±50.0 °C(Predicted)
Density 
1.297
storage temp. 
2-8°C
solubility 
Chloroform (Sparingly), Methanol (Slightly)
pka
14.17±0.20(Predicted)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
F595465
Product name
3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one
Packaging
500mg
Price
$135
Updated
2021/12/16
TRC
Product number
F595465
Product name
3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one
Packaging
5g
Price
$1070
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0038549
Product name
2-OXAZOLIDINONE, 3-[(5S)-5-(4-FLUOROPHENYL)-5-HYDROXY-1-OXOPENTYL]-4-PHENYL-, (4S)-
Purity
95.00%
Packaging
10G
Price
$1334.03
Updated
2021/12/16
AK Scientific
Product number
Y6621
Product name
(4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
Packaging
1g
Price
$18
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0038549
Product name
2-OXAZOLIDINONE, 3-[(5S)-5-(4-FLUOROPHENYL)-5-HYDROXY-1-OXOPENTYL]-4-PHENYL-, (4S)-
Purity
95.00%
Packaging
5G
Price
$255.15
Updated
2021/12/16
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(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Chemical Properties,Usage,Production

Description

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1, 3-OXAZOLIDIN-2-ONE is a derivative of 2-oxazolidine, which is an effective antimicrobial. It can be used as a pharmaceutical intermediate for the preparation of ezetimibe which is a drug used to lower the patients’ plasma cholesterol levels.

Chemical Properties

Solid

Uses

3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one is an intermediate of Ezetimibe (E975000, E975002), an antihyperlipoproteinemic. A cholesterol absorption inhibitor.

References

http://www.cphi-online.com/ezetimibe-intermediate-4s3-prod587443.html
https://en.wikipedia.org/wiki/2-Oxazolidone

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Suppliers

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View Lastest Price from (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE 189028-95-3
Price
US $1.00-0.00/KG
Min. Order
1KG
Purity
99%+
Supply Ability
10000KG
Release date
2019-12-27
Henan Aochuang Chemical Co.,Ltd.
Product
(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE 189028-95-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Qiuxian Baitai New Material Co., LTD
Product
(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE 189028-95-3
Price
US $10.00/g
Min. Order
1KG
Purity
98%
Supply Ability
500ton/Month
Release date
2021-12-21

189028-95-3, (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONERelated Search:

5-(4-FLUOROPHENYL)VALERIC ACID Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate (4S,5R)-5-[3,5-bis(triflu... 3-[5-(1,5-Dioxo-5-(p-fluophenylpentyl]-4R-phenyl-2-oxazolidinone (3R,4S)-1-(4-Fluorophenyl)-2-oxo-4-[4-(benzyloxy)phenyl]-3-azetidinepropanoic acid 3-O-Acetyl Ezetimibe ent-EzetiMibe EzetiMibe LactaM Cleaved Alcohol Dextran 4-(4-Fluorobenzoyl)butyric acid (4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone Ezetimibe 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde pyridine-3-sulfonyl chloride 4-[[(4-Fluorophenyl)imino]methyl]-phenol 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Flupirtine maleate PD 0332991 HCl

  • (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE
  • (4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
  • (4S)-4-Phenyl-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3-oxazolidin-2-one
  • (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxo-pentyl]-4-phenyl-2-Oxazolidinone
  • EzetiMibe InterMediates
  • 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-, (4S)- 2-Oxazolidinone
  • Ezetimibe INT A
  • ZT-5
  • 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-
  • (4S)-3-[(5R)-5-(4-Fluorophenyl)-5-Hydroxypentanoyl]-4-pheny-1,3-oxzolidin-2-One
  • 2-Oxazolidinone, 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-, (4S)-
  • -5-(4-Fluorophenyl)
  • -5-hydroxypentanoyl)
  • (S)-3-[(S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-2-oxazolidinone
  • Ezetimibe Impurity 45
  • Ezetimibe-003
  • Ezetimibe Impurity 51
  • 3-[5-(4-fluoro- phenyl)-5-hydroxy- pentanoyl]-5-phenyl- oxazolidin-2-one
  • 3-[5-(4-Fluoro-phenyl)-5-(S)-hydroxy-pentanoyl]-4-(R)-phenyl-oxazolidin-2-one
  • (S)-3-((S)-5-(4-FL
  • idin-2-one
  • )-5-hydroxypentanoyL
  • (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONEENYL-2-OXAZOLIDINONE
  • (4S)-3-[(5S)-5-(3-fluorophenyl)-5- hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
  • (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL...
  • Ezetimibe Impuriry 51
  • Ezetimibe intermediate D
  • <font color="#ff0000">189028-95-3</font>
  • (4S)-3-[(5S)-5-(3-FLUOROPHENYL)-5-
  • 3-[(5S)-5-(4-Fluorophenyl)-5-hydroxy-1-oxopentyl]-4(S)-phenyl-2-oxazolidinone
  • (4S) -3- [(5S) -5- (4-fluorophenyl) -5-hydroxyvaleryl] -4-phenyl-1,3-oxyazacyclopentane-2-one
  • (4S) -3- [(5S) -5- (4-fluorophenyl) -5-hydroxypentanoyl] -4-phenyl-1,3-oxazole-2-one
  • 189028-95-3
  • Ezetimibe
  • Ezetimibe intermediates
  • 189028-95-3