(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE

Product Name: (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE
CAS No.: 189028-95-3
Chemical Name: (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE
Synonyms: (4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one;ZT-5;idin-2-one;Ezetimibe-003;Ezetimibe INT A;(S)-3-((S)-5-(4-FL;-5-(4-Fluorophenyl);-5-hydroxypentanoyl);)-5-hydroxypentanoyL;Ezetimibe Impurity 45
CBNumber: CB71473325
Molecular Formula: C20H20FNO4
Formula Weight: 357.38
MOL File: 189028-95-3.mol

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(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Property

Boiling point:: 572.7±50.0 °C(Predicted)
Density: 1.297
storage temp.: 2-8°C
solubility: Chloroform (Sparingly), Methanol (Slightly)
pka: 14.17±0.20(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: F595465
Product name: 3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one
Packaging: 500mg
Price: $135
Updated: 2021/12/16

TRC

Product number: F595465
Product name: 3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one
Packaging: 5g
Price: $1070
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0038549
Product name: 2-OXAZOLIDINONE, 3-[(5S)-5-(4-FLUOROPHENYL)-5-HYDROXY-1-OXOPENTYL]-4-PHENYL-, (4S)-
Purity: 95.00%
Packaging: 10G
Price: $1334.03
Updated: 2021/12/16

AK Scientific

Product number: Y6621
Product name: (4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
Packaging: 1g
Price: $18
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0038549
Product name: 2-OXAZOLIDINONE, 3-[(5S)-5-(4-FLUOROPHENYL)-5-HYDROXY-1-OXOPENTYL]-4-PHENYL-, (4S)-
Purity: 95.00%
Packaging: 5G
Price: $255.15
Updated: 2021/12/16

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(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Chemical Properties,Usage,Production

Description

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1, 3-OXAZOLIDIN-2-ONE is a derivative of 2-oxazolidine, which is an effective antimicrobial. It can be used as a pharmaceutical intermediate for the preparation of ezetimibe which is a drug used to lower the patients’ plasma cholesterol levels.

Chemical Properties

Solid

Uses

3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one is an intermediate of Ezetimibe (E975000, E975002), an antihyperlipoproteinemic. A cholesterol absorption inhibitor.

References

http://www.cphi-online.com/ezetimibe-intermediate-4s3-prod587443.html
https://en.wikipedia.org/wiki/2-Oxazolidone

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Suppliers

China 268 India 9 United States 12 Global 289

Changzhou Yuanda Pharmaceutical Chemical Co., Ltd.

Tel: 0519-83984084
Fax: 0519-88776993
Email: sales@ydpharm.com
Country: China
ProdList: 119
Advantage: 60

Heading （Nanjing）Pharmtechnologies Co., Ltd.

Tel: 025-58467899-832 13382406280
Fax: 025-58467899
Email: liucheng@headingpharm.com
Country: China
ProdList: 45
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Nanjing Gold Pharmaceutical Technology Co. Ltd.

Tel: 028-025-84209270 15380463325
Fax: 025-84209270
Email: wgp@nanjing-pharmaceutical.com
Country: China
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Energy Chemical

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Enantiotech Corporation Ltd

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Jia Xing Isenchem Co.,Ltd

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Nanjing Chemlin Chemical Co., Ltd

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Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19172
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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
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XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8843
Advantage: 52

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
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View Lastest Price from (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE 189028-95-3
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%+
Supply Ability: 10000KG
Release date: 2019-12-27

Henan Aochuang Chemical Co.,Ltd.

Product: (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE 189028-95-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Qiuxian Baitai New Material Co., LTD

Product: (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE 189028-95-3
Price: US $10.00/g
Min. Order: 1KG
Purity: 98%
Supply Ability: 500ton/Month
Release date: 2021-12-21

189028-95-3, (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONERelated Search:

5-(4-FLUOROPHENYL)VALERIC ACID Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate (4S,5R)-5-[3,5-bis(triflu... 3-[5-(1,5-Dioxo-5-(p-fluophenylpentyl]-4R-phenyl-2-oxazolidinone (3R,4S)-1-(4-Fluorophenyl)-2-oxo-4-[4-(benzyloxy)phenyl]-3-azetidinepropanoic acid 3-O-Acetyl Ezetimibe ent-EzetiMibe EzetiMibe LactaM Cleaved Alcohol Dextran 4-(4-Fluorobenzoyl)butyric acid (4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone Ezetimibe 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde pyridine-3-sulfonyl chloride 4-[[(4-Fluorophenyl)imino]methyl]-phenol 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Flupirtine maleate PD 0332991 HCl

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE

(4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one

(4S)-4-Phenyl-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3-oxazolidin-2-one

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxo-pentyl]-4-phenyl-2-Oxazolidinone

EzetiMibe InterMediates

3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-, (4S)- 2-Oxazolidinone

Ezetimibe INT A

ZT-5

3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-

(4S)-3-[(5R)-5-(4-Fluorophenyl)-5-Hydroxypentanoyl]-4-pheny-1,3-oxzolidin-2-One

2-Oxazolidinone, 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-, (4S)-

-5-(4-Fluorophenyl)

-5-hydroxypentanoyl)

(S)-3-[(S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-2-oxazolidinone

Ezetimibe Impurity 45

Ezetimibe-003

Ezetimibe Impurity 51

3-[5-(4-fluoro- phenyl)-5-hydroxy- pentanoyl]-5-phenyl- oxazolidin-2-one

3-[5-(4-Fluoro-phenyl)-5-(S)-hydroxy-pentanoyl]-4-(R)-phenyl-oxazolidin-2-one

(S)-3-((S)-5-(4-FL

idin-2-one

)-5-hydroxypentanoyL

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONEENYL-2-OXAZOLIDINONE

(4S)-3-[(5S)-5-(3-fluorophenyl)-5- hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL...

Ezetimibe Impuriry 51

Ezetimibe intermediate D

(4S)-3-[(5S)-5-(3-FLUOROPHENYL)-5-

3-[(5S)-5-(4-Fluorophenyl)-5-hydroxy-1-oxopentyl]-4(S)-phenyl-2-oxazolidinone

(4S) -3- [(5S) -5- (4-fluorophenyl) -5-hydroxyvaleryl] -4-phenyl-1,3-oxyazacyclopentane-2-one

(4S) -3- [(5S) -5- (4-fluorophenyl) -5-hydroxypentanoyl] -4-phenyl-1,3-oxazole-2-one

189028-95-3

Ezetimibe

Ezetimibe intermediates

189028-95-3