ChemicalBook > CAS DataBase List > 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID

2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID

Product Name: 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
CAS No.: 128694-63-3
Chemical Name: 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
Synonyms: EU-0083300;ZERO/005391;MLS000850704;SMR000456721;TimTec1_003188;2-methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid;2-methyl-5-(trifluoromethyl)-3-pyrazolecarboxylic acid;Pyrazole-5-carboxylic acid, 3-trifluorromethyl-1-methyl-;1-Methyl-3-(trifluoromethy)-2H-pyrazole-5-caboxylic Acid;2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
CBNumber: CB71501950
Molecular Formula: C6H5F3N2O2
Formula Weight: 194.11
MOL File: 128694-63-3.mol

Less

2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID Property

Melting point:: 131-133℃
Boiling point:: 288.8±40.0 °C(Predicted)
Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: crystalline powder
pka: 2.55±0.25(Predicted)
color: White
InChI: InChI=1S/C6H5F3N2O2/c1-11-3(5(12)13)2-4(10-11)6(7,8)9/h2H,1H3,(H,12,13)
InChIKey: AQUQLOWJSBFHBD-UHFFFAOYSA-N
SMILES: N1(C)C(C(O)=O)=CC(C(F)(F)F)=N1

Less

Safety

Risk Statements: 22-36/37/38
Safety Statements: 26-36
HazardClass: IRRITANT
HS Code: 29331990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: B487523
Product name: 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylicAcid
Packaging: 100mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: Z2320
Product name: 1-Methyl-3-trifluoromethylpyrazole-5-carboxylicacid
Packaging: 250mg
Price: $131
Updated: 2021/12/16

Ark Pharm

Product number: P000718730
Product name: 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $160
Updated: 2021/12/16

Ark Pharm

Product number: P000718730
Product name: 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid
Purity: 97%
Packaging: 250mg
Price: $53
Updated: 2021/12/16

Ark Pharm

Product number: P000718730
Product name: 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid
Purity: 97%
Packaging: 100mg
Price: $26
Updated: 2021/12/16

Less

2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid is used in preparation of arylaminopyridine carboxamides as vanin inhibitors for treatment of vanin-mediated diseases.

Synthesis

1236144-18-5

128694-63-3

General procedure for the synthesis of 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid from ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate: To a 15 mL Schlenk reaction flask containing ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate (1.5 mmol) was added a solution of 1 N sodium hydroxide (2.5 mL), the The resulting mixture was stirred vigorously for 24 h at room temperature. Upon completion of the reaction, the reaction mixture was acidified with 6 N HCl at 0 °C. The resulting solid was collected by filtration and the solid was suspended in dichloromethane. The organic and aqueous layers were separated and the aqueous layer was further extracted with dichloromethane. All organic layers were combined and dried with anhydrous Na2SO4 and subsequently concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (eluent ratio: hexane/EtOAc = 5:1 to 2:1) to afford 1-methyl-3-trifluoromethyl-5-pyrazolecarboxylic acid (275 mg, 95% yield) as a white solid.

References

[1] Tetrahedron Letters, 2017, vol. 58, # 46, p. 4344 - 4347
[2] Angewandte Chemie - International Edition, 2013, vol. 52, # 24, p. 6255 - 6258

2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID Suppliers

China 109 India 1 United States 11 Global 121

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

PharmaBlock Sciences (Nanjing),Inc.

Tel: 025-86918202 4000255188
Fax: 86-025-86918232
Email: sales@pharmablock.com
Country: China
ProdList: 5000
Advantage: 55

Carbott PharmTech Inc.

Tel: 0535-6385396
Fax: +86 (535) 638-9971
Email: info@carbottpharm.com
Country: China
ProdList: 957
Advantage: 56

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Nanjing Habo Medical Technology Co., Ltd.

Tel: 025-85760892 13376080562
Fax: 025-85766769
Email: sales@habotech.com
Country: China
ProdList: 884
Advantage: 60

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Cochemical Ltd.

Tel: 029-86115547 17791676824
Fax: 02151602123
Email: sales@cochemical.com
Country: China
ProdList: 3014
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai ShiXian Chemical Technology Co., Ltd.

Tel: 18681884732
Fax: 021-51632502
Email: 2245256225@qq.com
Country: China
ProdList: 1728
Advantage: 50

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Changsha Luxing Bio-Chem Technology Co., Ltd.

Tel: 0731-88827538 15873153880
Fax: 0731-88827238
Email: luxingbc@126.com
Country: China
ProdList: 2002
Advantage: 65

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Tongling HengYou Biotechnology Co., Ltd.

Tel: 021-50426030 13856289449
Fax: 021-50426030
Email: 2630597085@qq.com
Country: China
ProdList: 1889
Advantage: 55

ShangHai Wisacheam Pharmaceutical Co., Ltd.

Tel: 13817485796
Fax: QQ:895624079
Email: tim@wisacheampharm.com
Country: China
ProdList: 3592
Advantage: 58

Shanghai Sainty Biotechnology Co., Ltd.

Tel: 021-58957915 17721108391
Fax: QQ: 907522080
Email: 907522080@qq.com
Country: China
ProdList: 997
Advantage: 55

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9279
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

Chengdu Xiaojia Technology Co., Ltd.

Tel: 15902830537
Email: zhanghao@happysyn.com
Country: China
ProdList: 3180
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Taian Jiaye Biotechnology Co.Ltd

Tel: 13127280945
Email: 285424065@qq.com
Country: China
ProdList: 9976
Advantage: 55

Wuxi AppTec

Tel: 022-59987777 13552403979
Email: jia_guoqiang@wuxiapptec.com
Country: China
ProdList: 22345
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15083
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Shanghai HongMin Pharmaceutical Co., Ltd.

Tel: 13651987816
Fax: -
Email: hongminpharm@163.com
Country: China
ProdList: 2326
Advantage: 58

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10295
Advantage: 58

Yujinpharma(Tianjin) Technology Co.,Ltd.

Tel: 13370351217 kungfu1217@1
Fax: QQ1400885609
Email: kungfu1217@163.com
Country: China
ProdList: 2720
Advantage: 58

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20557
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-037163312495,13303845143 13303845143
Fax: QQ3001379618
Email: 3001379618@qq.com
Country: China
ProdList: 10267
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shanghai silk sail pharmaceutical technology co., LTD

Tel: 18916696128
Email: service@snowpharm.com
Country: China
ProdList: 1369
Advantage: 58

Shanghai Scochem Technology Co., Ltd.

Tel: 021-33758897
Email: sales@scochem.com
Country: China
ProdList: 1596
Advantage: 58

Suzhou Adelaide Chemical Technology Co., Ltd.

Tel: 15995785122
Email: 3003020078@qq.com
Country: China
ProdList: 1198
Advantage: 58

Shanghai Runnuo Biotechnology Co., Ltd.

Tel: 010-80768286
Country: CHINA
ProdList: 90
Advantage: 58

Zhuzhou focus pharmaceutical technology co., LTD

Tel: +86-13776644403
Email: robert@focuspharma.cc
Country: China
ProdList: 2459
Advantage: 58

Allfluoro pharmaceutical co. ltd.

Tel: +86-400-0216110 +86-15958047586
Fax: 0086-21-33275002
Email: sales@allfluoro.com
Country: China
ProdList: 11385
Advantage: 58

Shanghai UCHEM Inc.

Tel: +862156762820 +86-13564624040
Email: sales@myuchem.com
Country: China
ProdList: 8460
Advantage: 58

Hunan Jibang Biological Technology Co., LTD

Tel: +8613776644403
Email: sales02@kingboomtech.com
Country: China
ProdList: 1804
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Baoji Guokang Healthchem co.,ltd

Tel: +8615604608665 15604608665
Email: dominicguo@gk-bio.com
Country: CHINA
ProdList: 9414
Advantage: 58

Blocksynth Pharmaceutical Technology Co.,Ltd

Tel: 0086-19817745290; +8619817745290
Email: bd@blocksynth.com
Country: China
ProdList: 5661
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15109
Advantage: 58

SIMAGCHEM CORP

Tel: +86-5922680277 +86-13806087780
Email: sale@simagchem.com
Country: China
ProdList: 17346
Advantage: 58

Jinan Ruisi Pharmaceutical Technology Co., LTD

Tel: 0531-0531-69900633 19963472814
Email: changyuan20@163.com
Country: China
ProdList: 2742
Advantage: 58

Less

View Lastest Price from 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID 128694-63-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-31

128694-63-3, 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACIDRelated Search:

5-Hydroxy-1-methylpyrazole 1-Methylpyrazole 4-BROMO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE 1-Methyl-3-(trifluoromethyl)-1H-pyrazol-4-amine ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID (1-Methyl-3-(trifluoroMethyl)-1H-pyrazol-4-yl)Methanol Ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate 2-(3-CYANO-4-FLUORO-PHENYL)-5-TRIFLUORO-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID 1-(4-METHOXYPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID 4-CHLORO-2-METHYL-5-TRIFLUOROMETHYL-2 H-PYRAZOLE-3-CARBOXYLIC ACID 2-ETHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID 4-BROMO-2-METHYL-5-TRIFLUOROMETHYL-2 H-PYRAZOLE-3-CARBOXYLIC ACID 2-ETHYL-5-TRIFLUOROMETHYL-2 H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER AKOS B030773 AKOS B030771 AKOS B030772

1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid(SALTDATA: FREE)

2-methyl-5-(trifluoromethyl)-3-pyrazolecarboxylic acid

2-methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid

EU-0083300

MLS000850704

Pyrazole-5-carboxylic acid, 3-trifluorromethyl-1-methyl-

SMR000456721

TimTec1_003188

ZERO/005391

1-Methyl-3-(trifluoromethy)-2H-pyrazole-5-caboxylic Acid

1H-Pyrazole-5-carboxylic acid, 1-methyl-3-(trifluoromethyl)-

1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-carboxylic acid

2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID

128694-63-3