2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
- Product Name
- 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
- CAS No.
- 128694-63-3
- Chemical Name
- 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
- Synonyms
- EU-0083300;ZERO/005391;MLS000850704;SMR000456721;TimTec1_003188;2-methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid;2-methyl-5-(trifluoromethyl)-3-pyrazolecarboxylic acid;Pyrazole-5-carboxylic acid, 3-trifluorromethyl-1-methyl-;1-Methyl-3-(trifluoromethy)-2H-pyrazole-5-caboxylic Acid;2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
- CBNumber
- CB71501950
- Molecular Formula
- C6H5F3N2O2
- Formula Weight
- 194.11
- MOL File
- 128694-63-3.mol
2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID Property
- Melting point:
- 131-133℃
- Boiling point:
- 288.8±40.0 °C(Predicted)
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- crystalline powder
- pka
- 2.55±0.25(Predicted)
- color
- White
- InChI
- InChI=1S/C6H5F3N2O2/c1-11-3(5(12)13)2-4(10-11)6(7,8)9/h2H,1H3,(H,12,13)
- InChIKey
- AQUQLOWJSBFHBD-UHFFFAOYSA-N
- SMILES
- N1(C)C(C(O)=O)=CC(C(F)(F)F)=N1
Safety
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- HazardClass
- IRRITANT
- HS Code
- 29331990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B487523
- Product name
- 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylicAcid
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- Z2320
- Product name
- 1-Methyl-3-trifluoromethylpyrazole-5-carboxylicacid
- Packaging
- 250mg
- Price
- $131
- Updated
- 2021/12/16
- Product number
- P000718730
- Product name
- 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- P000718730
- Product name
- 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $53
- Updated
- 2021/12/16
- Product number
- P000718730
- Product name
- 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid
- Purity
- 97%
- Packaging
- 100mg
- Price
- $26
- Updated
- 2021/12/16
2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid is used in preparation of arylaminopyridine carboxamides as vanin inhibitors for treatment of vanin-mediated diseases.
Synthesis
1236144-18-5
128694-63-3
General procedure for the synthesis of 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid from ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate: To a 15 mL Schlenk reaction flask containing ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate (1.5 mmol) was added a solution of 1 N sodium hydroxide (2.5 mL), the The resulting mixture was stirred vigorously for 24 h at room temperature. Upon completion of the reaction, the reaction mixture was acidified with 6 N HCl at 0 °C. The resulting solid was collected by filtration and the solid was suspended in dichloromethane. The organic and aqueous layers were separated and the aqueous layer was further extracted with dichloromethane. All organic layers were combined and dried with anhydrous Na2SO4 and subsequently concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (eluent ratio: hexane/EtOAc = 5:1 to 2:1) to afford 1-methyl-3-trifluoromethyl-5-pyrazolecarboxylic acid (275 mg, 95% yield) as a white solid.
References
[1] Tetrahedron Letters, 2017, vol. 58, # 46, p. 4344 - 4347
[2] Angewandte Chemie - International Edition, 2013, vol. 52, # 24, p. 6255 - 6258
2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID Suppliers
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- Country
- India
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View Lastest Price from 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID manufacturers
- Product
- 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID 128694-63-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-31