ChemicalBook > CAS DataBase List > 2-Methylpropaneboronic acid (1S,2S,3R,5S)-(+)-2,3-pinanediol ester

2-Methylpropaneboronic acid (1S,2S,3R,5S)-(+)-2,3-pinanediol ester

Product Name
2-Methylpropaneboronic acid (1S,2S,3R,5S)-(+)-2,3-pinanediol ester
CAS No.
84110-34-9
Chemical Name
2-Methylpropaneboronic acid (1S,2S,3R,5S)-(+)-2,3-pinanediol ester
Synonyms
(3aS,4S,6S,7aR);-3a,5,5-trimethyL;Bortezomib Impurity 50;Bortezomib Impurity N32;(3aS,4S,6S,7aR)-2-IsobutyL;Bortezomib impurities B1-2;hexahydro-4,6-methanobenzo[d][1,3,2]dioxaboroL;Bortezomib intermediate (+)-Pinanediol isobutanol borate;4,6-Methano-1,3,2-benzodioxaborole,hexahydro-3a,5,5-trimethy...;2-Methylpropaneboronic acid (1S,2S,3R,5S)-(+)-2,3-pinanediol ester
CBNumber
CB71518578
Molecular Formula
C14H25BO2
Formula Weight
236.16
MOL File
84110-34-9.mol
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2-Methylpropaneboronic acid (1S,2S,3R,5S)-(+)-2,3-pinanediol ester Property

Boiling point:
272.3±9.0℃ (760 Torr)
Density 
0.97±0.1 g/cm3 (20 ºC 760 Torr)
Flash point:
118.5±18.7℃
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
form 
liquid
color 
colorless
optical activity
Consistent with structure
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37
TSCA 
No
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BCH00026
Product name
2-Methylpropaneboronic Acid (1S,2S,3R,5S)-(+)-2,3-pinanediol ester
Packaging
1g
Price
$512
Updated
2023/01/07
TRC
Product number
M220423
Product name
2-Methylpropaneboronic Acid (1S,2S,3R,5S)-(+)-2,3-pinanediol ester
Packaging
100mg
Price
$60
Updated
2021/12/16
ChemSupplyAustralia
Product number
300145
Product name
(2-Methylpropy)boronic acid（1S,2S,3R,5S)-(+)-2,3-pinanediol ester, 99%
Packaging
1g
Price
$107.8
Updated
2021/12/16
AK Scientific
Product number
X6105
Product name
2-Methylpropaneboronic Acid (1S,2S,3R,5S)-(+)-2,3-pinanediol ester
Packaging
10g
Price
$301
Updated
2021/12/16
Matrix Scientific
Product number
076936
Product name
2-Methylpropaneboronic acid(1S,2S,3R,5S)-(+)-2,3-pinanediol ester
Packaging
500mg
Price
$522
Updated
2021/12/16
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2-Methylpropaneboronic acid (1S,2S,3R,5S)-(+)-2,3-pinanediol ester Chemical Properties,Usage,Production

Uses

suzuki reaction

Synthesis

84110-40-7

57022-61-4

84110-34-9

GENERAL STEPS: A reaction mixture of (1S,2S,3R,5S)-(+)-2,3-pinanediol (6.9 g) with isobutylboronic acid (4.4 g) in diethyl ether (49.3 mL) was stirred at room temperature for 23 hours. After the reaction was completed, anhydrous sodium sulfate (16.5 g) was added to dry the reaction mixture. The sodium sulfate was removed by filtration and the filter cake was washed with diethyl ether (69.4 mL). The organic phases were combined and concentrated under reduced pressure to give a colorless oily product (9.9 g, 100% GC purity, 97.2% yield). Mass spectrum (MS, m/z): 236, 221, 195, 167, 140, 134, 83, 67, 55, 43; 1H-NMR (DMSO-d6, δ): 4.27 (1H, dd, J = 2.1 Hz, 8.7 Hz), 2.30 (1H, m), 2.18 (1H, m), 1.96 (1H, t, J = 5.4 Hz ), 1.86 (1H, m), 1.79 (1H, sx, J = 6.8 Hz), 1.69 (1H, m), 1.30 (3H, s), 1.25 (3H, s), 1.02 (1H, d, J = 10.6 Hz), 0.9 (3H, d, J = 6.6 Hz), 0.81 (3H, s), 0.69 (2H, m).

References

[1] Patent: WO2009/4350, 2009, A1. Location in patent: Page/Page column 9
[2] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 4, p. 1018 - 1029

2-Methylpropaneboronic acid (1S,2S,3R,5S)-(+)-2,3-pinanediol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Methylpropaneboronic acid (1S,2S,3R,5S)-(+)-2,3-pinanediol ester manufacturers

Career Henan Chemical Co
Product
2-Methylpropaneboronic acid (1S,2S,3R,5S)-(+)-2,3-pinanediol ester 84110-34-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-20

84110-34-9, 2-Methylpropaneboronic acid (1S,2S,3R,5S)-(+)-2,3-pinanediol esterRelated Search:

2,3-Pyrazinedicarboxylic acid Bortezomib Impurity 35 Bortezomib Impurity 23 tert-Butyl Tosylate DISCONTINUED Bortezomib Impurity 5 1-Chloro-2-methylpropane Bortezomib Impurity 45 BOC-D-Phenylalanine N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Isobutaneboronic acid (S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID Bortezomib Impurity 47 HCl 1-Bromo-2-methylpropane Bortezomib Impurity 34 Bortezomib Impurity 43 HCl Bortezomib Impurity 24 Bortezomib Impurity 38 (S)-N-(1-AMino-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

  • (3aS,4S,6S,7aR)-2-Isobutyl-3a,5,5-triMethylhexahydro-4,6-Methanobenzo[d][1,3,2]dioxaborole
  • 2-Methylpropaneboronic acid (1S,2S,3R,5S)-(+)-2,3-pinanediol ester
  • Bortezomib Impurity 50
  • 2-(2-methylpropyl)-(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborole
  • (1S,2S,6R,8S)-4-isobutyl-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.0&lt
  • (2-Methyl propyl) boronic acid (1S,2S,3R,5S ) -(+) -2,3-pinanediol ester
  • (3aS,4S,6S,7aR)
  • -2-Isobutyl-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborole
  • 4,6-Methano-1,3,2-benzodioxaborole, hexahydro-3a,5,5-trimethyl-2-(2-methylpropyl)-, (3aS,4S,6S,7aR)-
  • 2-Methylpropaneboronic acid (1S,2S,3R,5S)-(+)-2,3-pinanediol ester (3aS,4S,6S,7aR)-2-Isobutyl-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborole
  • (3aS,4S,6S,7aR)-2-Isobutyl-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborole
  • Bortezomib intermediate (+)-Pinanediol isobutanol borate
  • (3aS,4S,6S,7aR)-2-IsobutyL
  • -3a,5,5-trimethyL
  • hexahydro-4,6-methanobenzo[d][1,3,2]dioxaboroL
  • (1S,2S,6R,8S)-2,9,9-trimethyl-4-(2-methylpropyl)-3,5-dioxa-4-boratricyclo[6.1.1.0^{2,6}]decane
  • 4,6-Methano-1,3,2-benzodioxaborole,hexahydro-3a,5,5-trimethy...
  • Bortezomib impurities B1-2
  • Bortezomib Impurity N32
  • 84110-34-9