2-Amino-5-bromobenzoic acid
Synthesis- Product Name
- 2-Amino-5-bromobenzoic acid
- CAS No.
- 5794-88-7
- Chemical Name
- 2-Amino-5-bromobenzoic acid
- Synonyms
- 5-BROMOANTHRANILIC ACID;5-BROMO-2-AMINOBENZOIC ACID;BUTTPARK 89\07-49;RARECHEM AL BO 1183;5-bromo-anthranilicaci;2-Amino-5-bromobenzoic;5-Bromoantharanilic Acid;2-amino-5-bromo-benzoicaci;Anthranilic acid, 5-bromo-;2-AMINO-5-BROMOBENZOIC ACID
- CBNumber
- CB7154465
- Molecular Formula
- C7H6BrNO2
- Formula Weight
- 216.03
- MOL File
- 5794-88-7.mol
2-Amino-5-bromobenzoic acid Property
- Melting point:
- 213-215 °C (lit.)
- Boiling point:
- 265.51°C (rough estimate)
- Density
- 1.6841 (rough estimate)
- refractive index
- 1.6120 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Soluble in methanol and dimethyl sulfoxide.
- form
- Powder
- pka
- 4.55±0.10(Predicted)
- color
- Beige
- Sensitive
- Light Sensitive
- Merck
- 14,1405
- BRN
- 639028
- InChI
- InChI=1S/C7H6BrNO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H,10,11)
- InChIKey
- CUKXRHLWPSBCTI-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(Br)=CC=C1N
- CAS DataBase Reference
- 5794-88-7(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Amino-5-bromobenzoic acid(5794-88-7)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37
- Safety Statements
- 26-38-36/37
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- CB2557670
- Hazard Note
- Harmful
- PackingGroup
- 6.1/PG 3
- HS Code
- 29224999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 260118
- Product name
- 2-Amino-5-bromobenzoic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $58.4
- Updated
- 2024/03/01
- Product number
- 260118
- Product name
- 2-Amino-5-bromobenzoic acid
- Purity
- 97%
- Packaging
- 25g
- Price
- $60
- Updated
- 2024/03/01
- Product number
- A1254
- Product name
- 5-Bromoanthranilic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $28
- Updated
- 2024/03/01
- Product number
- A1254
- Product name
- 5-Bromoanthranilic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $84
- Updated
- 2024/03/01
- Product number
- A11915
- Product name
- 2-Amino-5-bromobenzoic acid, 98%
- Packaging
- 5g
- Price
- $48.65
- Updated
- 2024/03/01
2-Amino-5-bromobenzoic acid Chemical Properties,Usage,Production
Synthesis
A solution of bromine (7.2 g, 2 mL, 40 mmol) in 47 mL glacial acetic acid was added dropwise to sodium 2-aminobenzoate (6.4 g, 40 mmol) in 32 mL of glacial acetic acid at 15 °С and the mixture was stirred for 1 h at the same temperature. The product was filtered off, washed with benzene and dried in the dark. The bromobenzoic acids containing mixture (0.5 g) was added to 10 mL of boiling water followed by the addition of 1.3 mL of concentrated hydrochloric acid and hot filtration under vacuum. The insoluble material contained 2-amino-3,5-dibromobenzoic acid, whereas 2- amino-5-bromobenzoic acid precipitated upon cooling of the filtrate. IR (suspension in nujol, cm−1 ): 3497, 3383, 1675, 1616, 1587, 1548, 1423, 1377, 1316, 1292, 1239, 1160, 1127, 812, 748, 691.
Chemical Properties
slight yellow to white powder
Physical properties
2-Amino-5-bromobenzoic acid has 17 atoms, meaning 45 vibrational modes in three main parts: Carboxyl group, amine group, and benzene. The molecule's most mechanically active parts are the carboxyl and amine groups. They exhibit rocking, swinging, and every kind of mechanical motion beside H immigrations between each other. For this reason, the molecule is not a simple carboxylic acid nor a primary amine[1].
Uses
It is used in the preparation of hepatitis C virus NS5b RNA polymerase inhibitors. Also used in the determination of cobalt, copper, nickel, and zinc.
Uses
2-Amino-5-bromobenzoic acid is a brominated derivative of Antharilinic Acid (A679222). 2-Amino-5-bromobenzoic acid displays plant growth-regulator activity. 2-Amino-5-bromobenzoic acid is used in the preparation of hepatitis C virus NS5b RNA polymerase inhibitors.
Preparation
2-Amino-5-bromobenzoic acid is synthesized from o-aminobenzoic acid by bromination.
Synthesis of 2-amino-5-bromobenzoic acid (4c, CAS: 5794-88-7) and 2-amino3,5-dibromobenzoic acid (4d, CAS: 609-85-8): A solution of bromine (7.2 g, 2 mL, 40 mmol) in 47 mL glacial acetic acid was added dropwise to sodium 2-aminobenzoate (6.4 g, 40 mmol) in 32 mL of glacial acetic acid at 15 °С and the mixture was stirred for 1 h at the same temperature. The product was filtered off, washed with benzene and dried in the dark. The bromobenzoic acids containing mixture (0.5 g) was added to 10 mL of boiling water followed by the addition of 1.3 mL of concentrated hydrochloric acid and hot filtration under vacuum. The insoluble material contained 2-amino-3,5-dibromobenzoic acid, whereas 2- amino-5-bromobenzoic acid precipitated upon cooling of the filtrate.
2-Amino-5-bromobenzoic acid (4c) IR (suspension in nujol, cm?1 ): 3497, 3383, 1675, 1616, 1587, 1548, 1423, 1377, 1316, 1292, 1239, 1160, 1127, 812, 748, 691.
References
[1] Kunduracioglu, Ahmet . "Tautomeric Forms of 2–Amino–5–Bromobenzoic Acid: A DFT Study for Structural and Molecular Orbital Analysis." (2021).
2-Amino-5-bromobenzoic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-Amino-5-bromobenzoic acid manufacturers
- Product
- 2-Amino-5-bromobenzoic acid 5794-88-7
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 2-Amino-5-bromobenzoic acid 5794-88-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2023-08-07
- Product
- 2-Amino-5-bromobenzoic acid 5794-88-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-12