1,2,3-Trifluoro-4-nitrobenzene
Uses- Product Name
- 1,2,3-Trifluoro-4-nitrobenzene
- CAS No.
- 771-69-7
- Chemical Name
- 1,2,3-Trifluoro-4-nitrobenzene
- Synonyms
- 2,3,4-TRIFLUORONITROBENZENE;1,2,3-Trifluoro-4-ni;4-chloro-2-fluroaniline;4-Trifluoronitrobenzene;2,3,4-Trifluornitrobenzene;3,4,5 TRIFLUORONITROBENZEN;2,3,4-TRIFLUORONITROBRNZENE;1,2,3-Trifluor-4-nitrobenzol;2,3-Trifluoro-4-nitrobenzene;1-nitro-2,3,4-trifluorobenzene
- CBNumber
- CB7155826
- Molecular Formula
- C6H2F3NO2
- Formula Weight
- 177.08
- MOL File
- 771-69-7.mol
1,2,3-Trifluoro-4-nitrobenzene Property
- Boiling point:
- 92 °C/20 mmHg (lit.)
- Density
- 1.541 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.492(lit.)
- Flash point:
- 200 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Light yellow to Yellow to Orange
- Specific Gravity
- 1.541
- BRN
- 2449746
- InChI
- InChI=1S/C6H2F3NO2/c7-3-1-2-4(10(11)12)6(9)5(3)8/h1-2H
- InChIKey
- ARCACZWMYGILNI-UHFFFAOYSA-N
- SMILES
- C1(F)=CC=C([N+]([O-])=O)C(F)=C1F
- CAS DataBase Reference
- 771-69-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37/39-24/25
- RIDADR
- UN2810
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29042090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 338362
- Product name
- 2,3,4-Trifluoronitrobenzene
- Purity
- 99%
- Packaging
- 25g
- Price
- $29
- Updated
- 2023/06/20
- Product number
- T1539
- Product name
- 2,3,4-Trifluoronitrobenzene
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- T1539
- Product name
- 2,3,4-Trifluoronitrobenzene
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $79
- Updated
- 2025/07/31
- Product number
- T896260
- Product name
- 2,3,4-Trifluoronitrobenzene
- Packaging
- 10g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- T896260
- Product name
- 2,3,4-Trifluoronitrobenzene
- Packaging
- 5g
- Price
- $45
- Updated
- 2021/12/16
1,2,3-Trifluoro-4-nitrobenzene Chemical Properties,Usage,Production
Uses
2,3,4-Trifluoronitrobenzene is a useful research chemical.
Chemical Properties
clear yellow liquid after melting
Uses
2,3,4-Trifluoronitrobenzene was employed as starting reagent in the synthesis of ofloxacin. It was also used in the synthesis of the third generation quinolones antibacterial drugs.
General Description
2,3,4-Trifluoronitrobenzene is a fluoronitrobenzene and its biotransformation under methanogenic conditions has been studied by semicontinuous and batch tests. 2,3,4-Trifluoronitrobenzene is an important pharmaceutical intermediate.
Synthesis
17700-09-3
771-69-7
General procedure for the synthesis of 2,3,4-trifluoronitrobenzene from 2,3,4-trichloronitrobenzene: (2) 240 g of DMSO and 120 g of 2,3,4-trichloronitrobenzene were added to an anhydrous reaction flask with stirring turned on, and the temperature was raised to 75-80 °C under reduced pressure with continuous stirring for 2 hours. Subsequently, 76.8 g of KF and 12 g of TBAB were added to the reaction system and dehydrated under reduced pressure at 75-80 °C for 2 h until no droplets of water fell from the distillation head. (3) The reaction system was slowly warmed up to 180 °C to start the reaction. The reaction process was monitored by gas chromatography (GC), and the reaction was completed when the content of both 2-fluoro-3,4-dichloronitrobenzene and 2,3-dichloro-4-fluoronitrobenzene decreased to less than 0.2% after 10 h. The reaction was completed when the content of 2-fluoro-3,4-dichloronitrobenzene and 2,3-dichloro-4-fluoronitrobenzene dropped below 0.2%. The reaction mixture was cooled to 70-75 °C, filtered, and the filtrate was vacuum distilled and reintroduced into the anhydrous reaction unit. 46 g of KF and 12 g of TBAF were added and dehydrated under reduced pressure at 75-80 °C for 2 h until no water droplets appeared in the distillation head. The reaction temperature was set to 120 °C and ultrasonic power to 20 kHz and the reaction was continued. The reaction was monitored by GC and completed after 2 hours. The reaction mixture was cooled to 70-75°C and filtered and the filtrate was distilled to separate DMSO from the product. The final yield of 2,3,4-trifluoronitrobenzene was 99.7%.
References
[1] Patent: CN107325001, 2017, A. Location in patent: Paragraph 0028-0029; 0031-0034; 0036-0039; 0041-0044; 0046
1,2,3-Trifluoro-4-nitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
1,2,3-Trifluoro-4-nitrobenzene Suppliers
- Tel
- --
- Fax
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- brunschwig@brunschwig.nl
- Country
- The Netherlands
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View Lastest Price from 1,2,3-Trifluoro-4-nitrobenzene manufacturers
- Product
- 1,2,3-Trifluoro-4-nitrobenzene 771-69-7
- Price
- US $1.00/g
- Min. Order
- 300g
- Purity
- 99.8%
- Supply Ability
- 20 TONS
- Release date
- 2025-11-04
- Product
- 1,2,3-Trifluoro-4-nitrobenzene 771-69-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-09-28
- Product
- 1,2,3-Trifluoro-4-nitrobenzene 771-69-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-31