(S)-N-BOC-4-Bromophenylalanine

Product Name: (S)-N-BOC-4-Bromophenylalanine
CAS No.: 62129-39-9
Chemical Name: (S)-N-BOC-4-Bromophenylalanine
Synonyms: BOC-L-4-BROMOPHE;BOC-PHE(4-BR)-OH;BOC-PHE(P-BR)-OH;Boc-L-4-Br-Phe-OH;BOC-P-BROMO-PHE-OH;BOC-4'-BROMO-L-PHE;BOC-L-PHE(4-BR)-OH;Boc-Phe(4-Br)-OH C;RARECHEM BK PT 0044;BOC-P-BROMO-L-PHE-OH
CBNumber: CB7156494
Molecular Formula: C14H18BrNO4
Formula Weight: 344.2
MOL File: 62129-39-9.mol

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(S)-N-BOC-4-Bromophenylalanine Property

Melting point:: 118 °C
Boiling point:: 475.3±40.0 °C(Predicted)
Density: 1.5311 (rough estimate)
refractive index: 1.6500 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 3.83±0.10(Predicted)
color: Off-white to light brown
optical activity: 14.001°(C=0.0025g/mL, MEOH, 20°C, 589nm)
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C14H18BrNO4/c1-14(2,3)20-13(19)16-11(12(17)18)8-9-4-6-10(15)7-5-9/h4-7,11H,8H2,1-3H3,(H,16,19)(H,17,18)/t11-/m0/s1
InChIKey: ULNOXUAEIPUJMK-NSHDSACASA-N
SMILES: C(O)(=O)[C@H](CC1=CC=C(Br)C=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference: 62129-39-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29223900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 672424
Product name: Boc-Phe(4-Br)-OH
Purity: ≥98.0%
Packaging: 1g
Price: $230
Updated: 2023/06/20

Usbiological

Product number: 264928
Product name: Boc-4-bromo-L-phenylalanine
Packaging: 2g
Price: $359
Updated: 2021/12/16

TRC

Product number: B674158
Product name: Boc-L-4-Bromophenylalanine
Packaging: 10g
Price: $205
Updated: 2021/12/16

Matrix Scientific

Product number: 041882
Product name: Boc-4-bromo-L-phenylalanine
Packaging: 25g
Price: $235
Updated: 2021/12/16

Chem-Impex

Product number: 04088
Product name: Boc-4-bromo-L-phenylalanine
Purity: ≥ 99% (HPLC)
Packaging: 1G
Price: $12.5
Updated: 2021/12/16

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(S)-N-BOC-4-Bromophenylalanine Chemical Properties,Usage,Production

Chemical Properties

off-white powder

Uses

N-Boc-4-bromo-L-phenylalanine is used as pharmaceutical intermediate.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

24250-84-8

62129-39-9

General procedure for the synthesis of (S)-3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propionic acid from di-tert-butyl dicarbonate and L-4-bromophenylalanine: To a mixed solution of (S)-2-amino-3-(4-bromophenyl)propionic acid (7.3 g, 30.0 mmol) in methanol (50 mL) and water (50 mL) was slowly added di-tert-butyl dicarbonate ( 6.9 g, 31.5 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by rotary evaporator. The residue was adjusted to pH=5 with dilute hydrochloric acid and then extracted with ethyl acetate (10 mL x 3). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated to afford (S)-3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propionic acid in white solid form (10.0 g, 96.9% yield), which could be used in the subsequent reaction without further purification.

References

[1] Patent: WO2015/32943, 2015, A1. Location in patent: Page/Page column 26
[2] Patent: WO2012/119941, 2012, A1. Location in patent: Page/Page column 112
[3] ACS Catalysis, 2015, vol. 5, # 9, p. 5410 - 5413

(S)-N-BOC-4-Bromophenylalanine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-N-BOC-4-Bromophenylalanine Suppliers

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View Lastest Price from (S)-N-BOC-4-Bromophenylalanine manufacturers

Career Henan Chemical Co

Product: (S)-N-BOC-4-Bromophenylalanine 62129-39-9
Price: US $10.00/KG
Min. Order: 10KG
Purity: 99%
Supply Ability: 100kg
Release date: 2018-07-31

62129-39-9, (S)-N-BOC-4-BromophenylalanineRelated Search:

L-Alanine D-Phenylalanine Phenprobamate 4-Bromobenzaldehyde N-Carbobenzyloxyglycine 3-Bromoanisole 4'-Bromopropiophenone 2-Bromobenzonitrile Bromoxynil octanoate 2-Bromofluorobenzene DL-Phenylalanine tert-Butanol N-(tert-Butoxycarbonyl)-L-phenylalanine L-Phenylalanine (R)-N-BOC-2-Bromophenylalanine (S)-N-BOC-2-Bromophenylalanine (S)-N-BOC-3-Bromophenylalanine, 98% ee, 95%,(S)-N-BOC-3-BROMOPHENYLALANINE BOC-(R)-ALPHA-(4-BROMOBENZYL)-PROLINE

(Tert-Butoxy)Carbonyl Phe(4-Br)-OH

BOC-PHE(4-BR)-OH

BOC-P-BROMO-L-PHE-OH

BOC-P-BROMO-PHENYLALANINE

BOC-P-BROMO-PHE-OH

BOC-PHE(P-BR)-OH

BOC-L-PHE(4-BR)-OH

BOC-(S)-2-AMINO-3-(4'-BROMOPHENYL)PROPANOIC ACID

BOC-4'-BROMO-L-PHE

BOC-4-BROMO-L-PHENYLALANINE

BOC-L-4-BROMOPHE

BOC-L-4-BROMOPHENYLALANINE

BOC-L-4-BROMOPHENYLALNINE

N-TERT-BUTOXYCARBONYL-4-BROMOPHENYL-L-ALANINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-4-BROMO-L-PHENYLALANINE

N-ALPHA-T-BUTOXYCARBONYL-L-4-BROMO-L-PHENYLALANINE

(S)-3-(4-BROMO-PHENYL)-2-TERT-BUTOXYCARBONYLAMINO-PROPIONIC ACID

(S)-N-BOC-4-BROMOPHENYLALANINE

RARECHEM BK PT 0044

(S)-Boc-2-amino-3-(4-bromophenyl)propionic acid

Boc-4-bromo-L-phenylalanine≥ 99% (HPLC)

N-Boc-L-3-(4-bromophenyl)alanine,99%e.e.

BOC-L-4-BROMOPHENYLALANINE 98%

N-tert-Butoxycarbonyl-L-Bromo Phenylalanine

(S)-N-BOC-4-Bromophenylalanine, 98% ee, 95%

4-Bromo-L-phenylalanine, N-BOC protected

N-ALPHA-T-BUTYLOXYCARBONYL-4-BROMO-L-PHENYLALANINE

Boc-L-4-Br-Phe-OH

BOC-D-4-BROMO-PHE-OH

N-BOC-4-BROMO-L-PHENYLALANINE

(S)-N-Boc-4-bromophenylalanine, 95%, ee:98%

(S)-N-BOC-4-Bromophenylalanine,95%,98% ee

Boc-L-3-(4-Bromophenyl)alanine

Boc-L-4-Br-Phe-OH Boc-4-BroMo-L-Phenylalanine

(S)-N-BOC-4-BroMophenylalanine, 98% ee, 95% 500MG

4-broMo-N-(tert-butoxycarbonyl)-L-phenylalanine

(S)-3-(4-BroMophenyl)-2-((tert-butoxycarbonyl)aMino)propanoic acid

4-bromo-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalanine

N-Boc-L-3-(4-bromophenyl)alanine

4-Bromo-L-phenylalanine, N-BOC protected 97%

(S)-3-(4-bromophenyl)-2-(tert-butoxycarbonyl)propanoic acid

(S)-N-Boc-4-BromophenyL

L-Phenylalanine, 4-bromo-N-[(1,1-dimethylethoxy)carbonyl]-

(S)-N-BOC-4-Bromophenylalanine USP/EP/BP

Boc-Phe(4-Br)-OH C

62129-39-9 (S)-N-BOC-4-Bromophenylalanine

(2S)-3-(4-bromophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid

(S)-3-(4-bromophenyl)-2-((tertbutyloxyoxo)amino)propanoic acid

(S)-Boc-4-Bromophenylalanine

(2S)-2-(tert-Butoxycarbonylamino)-3-(4-bromophenyl)propanoic acid

N-Boc-4-bromo-L-phenylalanine,97%

(2S)-2-(N-BOC-Amino)-3-(4-bromophenyl)-propanoic acid

62129-39-9

62126-39-9

C14H18BrNO4

C14H18NO4Br

Phenylalanine analogs and other aromatic alpha amino acids

Amino Acids