ChemicalBook > CAS DataBase List > 2-(chloromethyl)-4-methylquinazoline

2-(chloromethyl)-4-methylquinazoline

Product Name
2-(chloromethyl)-4-methylquinazoline
CAS No.
109113-72-6
Chemical Name
2-(chloromethyl)-4-methylquinazoline
Synonyms
Quinazoline,2-(chloroMethyl)-4-Methyl-;Linaint-I;Linagliptin INT3;Linagliptin Impurity 67;Linagliptin interMediate A;CHLOROMETHYL)-4-METHYLQUINAZOLINE;2-chloroMethyl-4-Methyl quinaoline;2-(chloromethyl)-4-methylquizoline;Linagliptin 2-Chloromethyl Impurity;2-(chloromethyl)-4-methylquinazolin
CBNumber
CB71648970
Molecular Formula
C10H9ClN2
Formula Weight
192.64
MOL File
109113-72-6.mol
More
Less

2-(chloromethyl)-4-methylquinazoline Property

Melting point:
61.0 to 65.0 °C
Boiling point:
240.0±32.0 °C(Predicted)
Density 
1.251
vapor pressure 
0Pa at 20℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
powder to crystal
pka
1.86±0.50(Predicted)
color 
Light yellow to Yellow to Orange
Water Solubility 
3.11g/L at 20℃
λmax
318nm(EtOH)(lit.)
InChIKey
UHCUBOJGMLASBY-UHFFFAOYSA-N
LogP
1.9 at 25℃
More
Less

Safety

RIDADR 
3261
HazardClass 
8
PackingGroup 
III
HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
C2928
Product name
2-(Chloromethyl)-4-methylquinazoline
Purity
>98.0%(GC)
Packaging
1g
Price
$78
Updated
2024/03/01
TCI Chemical
Product number
C2928
Product name
2-(Chloromethyl)-4-methylquinazoline
Purity
>98.0%(GC)
Packaging
200mg
Price
$28
Updated
2024/03/01
TRC
Product number
C369850
Product name
2-(Chloromethyl)-4-methylquinazoline
Packaging
2.5g
Price
$95
Updated
2021/12/16
TRC
Product number
C369850
Product name
2-(Chloromethyl)-4-methylquinazoline
Packaging
5g
Price
$155
Updated
2021/12/16
TRC
Product number
C369850
Product name
2-(Chloromethyl)-4-methylquinazoline
Packaging
25g
Price
$400
Updated
2021/12/16
More
Less

2-(chloromethyl)-4-methylquinazoline Chemical Properties,Usage,Production

Chemical Properties

White to yellow powder

Uses

2-(Chloromethyl)-4-methylquinazoline, is a building block used for the preparation of Linagliptin (L465900), and its impurities, acting as type 2 diabetes drugs.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 23, p. 1263, 1986 DOI: 10.1002/jhet.5570230458

Flammability and Explosibility

Not classified

Synthesis

Into a 500ml reaction flask, add o-aminoacetophenone, chloroacetonitrile, 1,4-dioxane, and N-methyl-3(3-sulfopropyl)imidazolium hydrogen sulfate prepared above. Stir to dissolve, cool the reaction system to 8°C, and dropwise add hydrochloric acid to the reaction system. The reaction temperature was kept unchanged during the dropwise addition. After that, the reaction was continued at 8°C for 18 hours to complete the reaction process. After the reaction, ammonia water (the concentration of ammonia water was 10wt%) at 5°C was added to the reaction system. After stirring and crystallizing at 5 for 30 minutes, filter to obtain a filter cake, washing the filter cake with water. Recrystallized with 200ml of dichloromethane to obtain 2-(chloromethyl)-4-methylquinazoline. yield: 85.14%

2-(chloromethyl)-4-methylquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-(chloromethyl)-4-methylquinazoline Suppliers

Americas 1 China 379 Europe 1 India 81 Japan 1 Switzerland 2 Ukraine 1 United Kingdom 3 United States 13 Global 482
Emei shan Hongsheng Pharmaceutical Co., LTD
Tel
0833-6186272、6186278、6170066 18990613291
Fax
0833-5590359
Email
sales@hongshengpharm.com
Country
China
ProdList
58
Advantage
60
Shandong Sihuan Pharmaceutical Co., Ltd.
Tel
0531-88993893 13335127975
Fax
QQ:787658403
Email
fairouz@sdsihuanpharm.com
Country
China
ProdList
91
Advantage
58
Shijiazhuang Qiyue Chemical Co. LTD
Tel
15369111890 15369111890
Fax
15369111890
Email
sjzqiyuekeji@163.com
Country
China
ProdList
246
Advantage
58
Suzhou lipin Chemical Co., Ltd
Tel
0512-67509664 19888480046
Email
3516936381@qq.com
Country
China
ProdList
107
Advantage
58
Jinan Dexinjia Bio&Tech Co., Ltd
Tel
0531-8237592 15562613975
Fax
0531-82375893
Email
3416953599@qq.com
Country
China
ProdList
1199
Advantage
58
ShenZhen H&D Pharmaceutical Technology Co., LTD
Tel
18126517264
Email
2850476883@qq.com
Country
China
ProdList
2182
Advantage
58
Beijing Huikang Boyuan Chemical Tech Co., Ltd
Tel
010-68862197 13810598707
Fax
010-68882204
Email
sales@huikangchem.com
Country
China
ProdList
111
Advantage
61
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9551
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
18089
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
Country
China
ProdList
42982
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4388
Advantage
65
Shanghai Sphchem Co., Ltd.
Tel
21-21-56491756 13512199871
Fax
021-5649-1756
Email
sales@panhongchem.com
Country
China
ProdList
4000
Advantage
55
Jinan Bond Chemical Technology Co., Ltd.
Tel
86-531-88280989
Fax
86-531-88280989
Email
mymail1996@126.com
Country
China
ProdList
258
Advantage
55
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5654
Advantage
65
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9900
Advantage
58
Chengdu Yuyang High-Tech Developing Co., Ltd
Tel
+86-28-61777709
Fax
+86-28-61777709
Email
yygk@yygk.com
Country
China
ProdList
69
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6181
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25014
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Acesys Pharmatech
Tel
18860950986
Email
tangmanman@zenjipharma.com
Country
China
ProdList
1735
Advantage
55
China Nobel Chem Co., Limited
Tel
+86(0)21 60484900
Fax
+86(0)21 60484900
Country
China
ProdList
764
Advantage
50
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2867
Advantage
52
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7876
Advantage
55
Cangzhou Senary Chemical Science-tech Co., Ltd
Tel
+86-317-3563899
Fax
+86-317-3563199
Email
trade@senary.com
Country
China
ProdList
98
Advantage
56
CEG Chemical Science&Technology Co., Ltd.
Tel
Mobile:13665161512
Fax
+86-510-68873513
Country
China
ProdList
1785
Advantage
58
Suzhou lipin Chemical Co., Ltd
Tel
0512-0512-67509664 19888480046
Country
China
ProdList
121
Advantage
58
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9986
Advantage
55
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
PingHeAnKang Pharmaceutical Co., Ltd.
Tel
18086832706
Fax
028-89642128
Email
phakzjtxs@phak.cn
Country
China
ProdList
138
Advantage
58
Suzhou Lakestar Pharmatech Co., Ltd.
Tel
0512-63970158-603 18018108880
Fax
0512-63971078
Email
info@lakestarpharma.com
Country
China
ProdList
411
Advantage
59
Porse Fine Chemical Co.,LTD
Tel
20-66003216 18666003216
Fax
+86-20-28069063
Email
info@porsefinechemical.com
Country
China
ProdList
2134
Advantage
62
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17994
Advantage
56
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15185
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9636
Advantage
58
Shanghai SE Pharm Co., Ltd
Tel
18112588827
Email
sales4@sepharm.com.cn
Country
China
ProdList
307
Advantage
60
Hefei HomeSunshine Pharmaceutical Technology Co., Ltd.
Tel
0551-65523315 17705606359
Fax
0551-65523375
Email
errol@homesunshinepharma.com
Country
China
ProdList
70
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4951
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10287
Advantage
55
Hydragon Pharma Ltd
Tel
021-50215258
Fax
021-50215756
Email
market@hypharma.com
Country
China
ProdList
321
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
10015
Advantage
53
Lihe Wuhan New Chemical Materials Co., Ltd.
Tel
027-88395709
Fax
027-88391805
Country
China
ProdList
430
Advantage
50
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6490
Advantage
50
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9503
Advantage
50
Guangzhou Ciming Biological Technology Co., Ltd.
Tel
020-38082199,29065168,38082986,29878298,29866629,4000192398
Fax
+86 (20)38082986
Country
China
ProdList
831
Advantage
60
More
Less

View Lastest Price from 2-(chloromethyl)-4-methylquinazoline manufacturers

Nanjing Fred Technology Co., Ltd
Product
2-(chloromethyl)-4-methylquinazoline 109113-72-6
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1 ton
Release date
2023-11-17
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Linagliptin Impurity 67
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-05-08
Shanghai Joiny Pharmaceutical Co.,LTD
Product
2-(Chloromethyl)-4-methylquinazoline 109113-72-6
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
hundreds of kg
Release date
2022-02-17

109113-72-6, 2-(chloromethyl)-4-methylquinazolineRelated Search:

Acarbose Voriconazole 13,14-Didehydromatridin-15-one Donepezil Posaconazole Carbasalate calcium 1-BROMO-2-BUTYNE

  • 2-(chloromethyl)-4-methylquinazoline
  • Quinazoline,2-(chloroMethyl)-4-Methyl-
  • Linagliptin interMediate A
  • 2-chloroMethyl-4-Methyl quinaoline
  • Linagliptin INT3
  • Linaint-I
  • 2-(chloromethyl)-4-methylquizoline
  • Linagliptin 2-Chloromethyl Impurity
  • 2-(Chloromethyl)-4-methylquinazoline &gt
  • 2-(chloromethyl)-4-methylquinazolin
  • CHLOROMETHYL)-4-METHYLQUINAZOLINE
  • 2-(chloromethyl)-4-methylquinazoline ISO 9001：2015 REACH
  • Linagliptin intermediates，2-(chloromethyl)-4-methylquinazoline
  • (2-(chloromethyl)-4-methylquinazoline)，2-(chloromethyl)-4-methylquinazoline
  • Linagliptin Impurity 67
  • 2-(chloromethyl)-4-methylquinazolineQ: What is 2-(chloromethyl)-4-methylquinazoline Q: What is the CAS Number of 2-(chloromethyl)-4-methylquinazoline Q: What is the storage condition of 2-(chloromethyl)-4-methylquinazoline
  • Linagliptin Impurity 35(Not Continued,see C4X-110132)
  • 2-(Chloromethyl)-4-Methylquinazoline / Linagliptin Intermediate
  • Linagliptin intermediate Quinazoline, 2-(chloromethyl)-4-methyl-
  • 2-(Chloromethyl)-4-methylquinazoline (2-CMQ)
  • 109113-72-6
  • 109133-72-6
  • Intermediates
  • 109113-72-6