ChemicalBook > CAS DataBase List > 2-(chloromethyl)-4-methylquinazoline

2-(chloromethyl)-4-methylquinazoline

Product Name
2-(chloromethyl)-4-methylquinazoline
CAS No.
109113-72-6
Chemical Name
2-(chloromethyl)-4-methylquinazoline
Synonyms
Quinazoline,2-(chloroMethyl)-4-Methyl-;Linaint-I;Linagliptin INT3;Linagliptin Impurity 67;Linagliptin interMediate A;CHLOROMETHYL)-4-METHYLQUINAZOLINE;2-chloroMethyl-4-Methyl quinaoline;2-(chloromethyl)-4-methylquizoline;Linagliptin 2-Chloromethyl Impurity;2-(chloromethyl)-4-methylquinazolin
CBNumber
CB71648970
Molecular Formula
C10H9ClN2
Formula Weight
192.64
MOL File
109113-72-6.mol
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2-(chloromethyl)-4-methylquinazoline Property

Melting point:
61.0 to 65.0 °C
Boiling point:
240.0±32.0 °C(Predicted)
Density 
1.251
vapor pressure 
0Pa at 20℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
powder to crystal
pka
1.86±0.50(Predicted)
color 
Light yellow to Yellow to Orange
Water Solubility 
3.11g/L at 20℃
λmax
318nm(EtOH)(lit.)
InChIKey
UHCUBOJGMLASBY-UHFFFAOYSA-N
LogP
1.9 at 25℃
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Safety

RIDADR 
3261
HazardClass 
8
PackingGroup 
III
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2928
Product name
2-(Chloromethyl)-4-methylquinazoline
Purity
>98.0%(GC)
Packaging
1g
Price
$78
Updated
2024/03/01
TCI Chemical
Product number
C2928
Product name
2-(Chloromethyl)-4-methylquinazoline
Purity
>98.0%(GC)
Packaging
200mg
Price
$28
Updated
2024/03/01
TRC
Product number
C369850
Product name
2-(Chloromethyl)-4-methylquinazoline
Packaging
2.5g
Price
$95
Updated
2021/12/16
TRC
Product number
C369850
Product name
2-(Chloromethyl)-4-methylquinazoline
Packaging
5g
Price
$155
Updated
2021/12/16
TRC
Product number
C369850
Product name
2-(Chloromethyl)-4-methylquinazoline
Packaging
25g
Price
$400
Updated
2021/12/16
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2-(chloromethyl)-4-methylquinazoline Chemical Properties,Usage,Production

Chemical Properties

White to yellow powder

Uses

2-(Chloromethyl)-4-methylquinazoline, is a building block used for the preparation of Linagliptin (L465900), and its impurities, acting as type 2 diabetes drugs.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 23, p. 1263, 1986 DOI: 10.1002/jhet.5570230458

Flammability and Explosibility

Not classified

Synthesis

Into a 500ml reaction flask, add o-aminoacetophenone, chloroacetonitrile, 1,4-dioxane, and N-methyl-3(3-sulfopropyl)imidazolium hydrogen sulfate prepared above. Stir to dissolve, cool the reaction system to 8°C, and dropwise add hydrochloric acid to the reaction system. The reaction temperature was kept unchanged during the dropwise addition. After that, the reaction was continued at 8°C for 18 hours to complete the reaction process. After the reaction, ammonia water (the concentration of ammonia water was 10wt%) at 5°C was added to the reaction system. After stirring and crystallizing at 5 for 30 minutes, filter to obtain a filter cake, washing the filter cake with water. Recrystallized with 200ml of dichloromethane to obtain 2-(chloromethyl)-4-methylquinazoline. yield: 85.14%

2-(chloromethyl)-4-methylquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(chloromethyl)-4-methylquinazoline Suppliers

Americas 1 China 379 Europe 1 India 81 Japan 1 Switzerland 2 Ukraine 1 United Kingdom 3 United States 13 Global 482
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View Lastest Price from 2-(chloromethyl)-4-methylquinazoline manufacturers

Nanjing Fred Technology Co., Ltd
Product
2-(chloromethyl)-4-methylquinazoline 109113-72-6
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1 ton
Release date
2023-11-17
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Linagliptin Impurity 67
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-05-08
Shanghai Joiny Pharmaceutical Co.,LTD
Product
2-(Chloromethyl)-4-methylquinazoline 109113-72-6
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
hundreds of kg
Release date
2022-02-17

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