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Isobutyl chloroformate

Product Name
Isobutyl chloroformate
CAS No.
543-27-1
Chemical Name
Isobutyl chloroformate
Synonyms
IBCF;isobutyl carbonochloridate;ISOBUTYL CHLOROCARBONATE;2-Methylpropyl chloroformate;isobutyl chloformate;2-Methylpropyl carbonochloridate;2-methyl-1-propylchlorocarbonate;oroformate;Isobutyl chloroforma;Pramoxine Impurity 9
CBNumber
CB7165612
Molecular Formula
C5H9ClO2
Formula Weight
136.58
MOL File
543-27-1.mol
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Isobutyl chloroformate Property

Melting point:
-80°C
Boiling point:
128.8 °C(lit.)
Density 
1.053 g/mL at 25 °C(lit.)
vapor pressure 
0.33 mm Hg ( 20 °C)
refractive index 
n20/D 1.407(lit.)
Flash point:
82 °F
storage temp. 
2-8°C
solubility 
benzene: miscible
form 
Liquid
color 
Clear
Water Solubility 
Immiscible with water.
Sensitive 
Moisture Sensitive
Merck 
14,5139
BRN 
956590
Dielectric constant
9.2(20℃)
Stability:
Moisture Sensitive
CAS DataBase Reference
543-27-1(CAS DataBase Reference)
NIST Chemistry Reference
Isobutyl chloroformate(543-27-1)
EPA Substance Registry System
Isobutyl chloroformate (543-27-1)
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Safety

Hazard Codes 
T
Risk Statements 
10-22-23-34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3390 6.1/PG 1
WGK Germany 
2
10-19
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
I
HS Code 
29159000
Toxicity
LD50 orally in Rabbit: 1400 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H331Toxic if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.02358
Product name
Isobutyl chloroformate
Purity
for synthesis
Packaging
100mL
Price
$47.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.02358
Product name
Isobutyl chloroformate
Purity
for synthesis
Packaging
2.5L
Price
$528
Updated
2024/03/01
Sigma-Aldrich
Product number
177989
Product name
Isobutyl chloroformate
Purity
98%
Packaging
25g
Price
$41.3
Updated
2024/03/01
Sigma-Aldrich
Product number
177989
Product name
Isobutyl chloroformate
Purity
98%
Packaging
100g
Price
$43.4
Updated
2024/03/01
Alfa Aesar
Product number
A14692
Product name
Isobutyl chloroformate, 98%
Packaging
25g
Price
$23.2
Updated
2024/03/01
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Isobutyl chloroformate Chemical Properties,Usage,Production

Chemical Properties

clear liquid

Chemical Properties

A combustible, colorless to light-colored liquid.

Uses

Isobutyl chloroformate is used as a peptide reagent. It is also used in the preparation of phenethyl-carbamic acid isobutyl ester by reaction with phenethylamine.

General Description

A colorless to light-colored liquid. Insoluble in water and denser than water. Very corrosive to skin, eyes, and mucous membranes. Very toxic by ingestion, inhalation and skin absorption. Combustible.

Air & Water Reactions

Highly flammable. Insoluble in water. Reacts with moisture in the air to produce highly corrosive and toxic fumes of hydrogen chloride gas. Decomposes exothermically in water.

Reactivity Profile

Isobutyl chloroformate is incompatible with water, with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Hazard

Flammable. Corrosive.

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

reaction suitability

reaction type: Coupling Reactions

Potential Exposure

This is a high volume chemical with production exceeding 1 million pounds annually in the U.S . No specific use found

Shipping

UN2742 Chloroformates, toxic, corrosive, flammable, n.o.s., Hazard class: 6.1; Labels: 6.1—Poison Inhalation Hazard, 8—Corrosive material; 3—Flammable liquid; Technical Name Required, Potential Inhalation Hazard (Special Provision 5). PG II. UN3390 Toxic by inhalation liquid, corrosive, n.o.s. with an LC50 # 1000 mL/m3 and saturated vapor concentration ≥ 10 LC50, Hazard Class: 6.1; Labels: 6.1—Poisonous materials, 8—Corrosive material, Technical Name Required, Inhalation Hazard Zone B

Purification Methods

It can be dried over CaCl2 and fractionated at atmospheric pressure while keeping moisture out. Its purity can be checked by conversion to the phenyl urethane derivative with PhNCO [Saunders et al. J Am Chem Soc 73 3796 1951.] IR: 1780cm-1 [Thompson & Jameson Spectrochim Acta 13 236 1959, R.se JustusLiebigs Ann Chem 205 227 1880]. [Beilstein 3 IV 26.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alcohols, ethers, amines. Forms explosive mixture with air above flash point (27C). Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur). Decomposes exothermically in water. Reacts with moisture in air to produce highly corrosive and toxic fumes of hydrogen chloride gas

Waste Disposal

Disposal of unused product must be undertaken by qualified personnel who are knowledgeable in all applicable regulations and follow all pertinent safety precautions including the use of appropriate protective equipment. For proper handling and disposal, always comply with federal, state, and local regulations.

Isobutyl chloroformate Preparation Products And Raw materials

Raw materials

Preparation Products

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Isobutyl chloroformate Suppliers

HBCChem, Inc.
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View Lastest Price from Isobutyl chloroformate manufacturers

Career Henan Chemical Co
Product
Isobutyl chloroformate 543-27-1
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

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