N-Benzoylaminopurine

Product Name: N-Benzoylaminopurine
CAS No.: 4005-49-6
Chemical Name: N-Benzoylaminopurine
Synonyms: N-BENZOYLADENINE;N6-BENZOYLADENINE;N6-BENZOYLAMINOPURINE;N-BZ-ADE;N4-Bz-adenine;N-(9H-Purin-6-yL;6-BENZAMIDOPURINE;N4-Benzoyl adenine;N-Benzolaminopurine;6-Benzoylaminopurin
CBNumber: CB7165920
Molecular Formula: C12H9N5O
Formula Weight: 239.23
MOL File: 4005-49-6.mol

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N-Benzoylaminopurine Property

Melting point:: 242-244°C
Density: 1.494 g/cm3
storage temp.: 2-8°C
Water Solubility: Insoluble in water
solubility: DMSO (Slightly), Methanol (Slightly)
form: powder to crystal
pka: 11.98±0.20(Predicted)
color: White to Almost white
BRN: 20585
InChI: InChI=1S/C12H9N5O/c18-12(8-4-2-1-3-5-8)17-11-9-10(14-6-13-9)15-7-16-11/h1-7H,(H2,13,14,15,16,17,18)
InChIKey: QQJXZVKXNSFHRI-UHFFFAOYSA-N
SMILES: C(NC1=C2C(=NC=N1)NC=N2)(=O)C1=CC=CC=C1
CAS DataBase Reference: 4005-49-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-43
Safety Statements: 36/37
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B5258
Product name: N6-Benzoyladenine
Purity: ≥99%
Packaging: 5G
Price: $143.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: B5258
Product name: N6-Benzoyladenine
Purity: ≥99%
Packaging: 25G
Price: $864
Updated: 2024/03/01

TCI Chemical

Product number: B3344
Product name: N6-Benzoyladenine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $117
Updated: 2024/03/01

TCI Chemical

Product number: B3344
Product name: N6-Benzoyladenine
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $257
Updated: 2024/03/01

Alfa Aesar

Product number: L08292
Product name: N-Benzoylaminopurine, 99%
Packaging: 1g
Price: $51.65
Updated: 2024/03/01

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N-Benzoylaminopurine Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

N6-Benzoyladenine is used in the organic synthesis of adenine derivative molecules such as bicyclic adenine nucleoside via a condensation reaction between L-threo-pentofuranose derivative 1 and 6-N-benzoyladenine and to produce oxy-peptide nucleic acids.

Definition

ChEBI: 6-Benzamidopurine is a member of purines.

Biochem/physiol Actions

N6-Benzoyladenine comprises of adenine moiety and is a potent inhibitor of bromodomain-containing protein 4 (BRD4). N6-Benzoyladenine modulates tumor necrosis factor α (TNF-α) levels. It elicits cytotoxicity in liver and ileum cancer cells and may serve as a potential candidate agent for cancer chemotherapy.

Synthesis

Benzoyl chloride (1.3 mL, 11 mmol) was added dropwise over 30 min to a stirred suspension of adenine (1.35 g, 10 mmol) in dry pyridine, and stirring was continued at 100 °C for a further 3 h, and the reaction mixture was allowed to stand overnight at room temperature. The reaction was quenched with methanol and the solvents were removed under reduced pressure. The residue was triturated in hot isopropanol and dried in vacuo to give 8 as a white solid: yield 2.15 g (90%). MS (+ESI): m/z 240 [M+H]+; 1H NMR (400 MHz, d-DMSO): δ11.50 (s, 1H), 8.74 (s, 1H), 8.52 (s, 1H), 8.11 (d, 2H, J = 7.2 Hz), 7.66 (t, 1H, J = 7.2 Hz), 7.58 (t, 2H, J = 7.2 Hz).

N-Benzoylaminopurine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Benzoylaminopurine Suppliers

Americas 1 China 224 Europe 3 Germany 4 India 7 Japan 1 Russia 1 South Korea 1 Switzerland 1 United Kingdom 10 United States 24 Global 277

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View Lastest Price from N-Benzoylaminopurine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: N6-Benzoylaminopurine 4005-49-6
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-19

Henan Fengda Chemical Co., Ltd

Product: N6-Benzoylaminopurine 4005-49-6
Price: US $122.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-11

Career Henan Chemical Co

Product: N-(5H-Purin-6-yl)benzamide 4005-49-6
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-15

4005-49-6, N-BenzoylaminopurineRelated Search:

Adenine Sulfate Chlorantraniliprole Adenine phosphate salt（1：1） Benzamide Adenine N6-Benzoyl-2'-deoxyadenosine N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine DMT-2'O-TBDMS-rA(bz) Phosphoramidite DMT-dA(bz) Phosphoramidite N-BENZOYLADENOSINE 5'-O-(4,4'-DIMETHOXYTRITYL)-N6-BENZOYL-2'-DEOXYADENOSINE-3'-O-SUCCINIC ACID 3'-DA CEP N6,3'-O-DIBENZOYL-2'-DEOXYADENOSINE N6-ANISOYLADENOSINE N-Benzoylaminopurine AURORA 5003 5'DIMETHOXYTRITYL DA(BZ)+DG(IBU)+DC(BZ)+T BETA-CYANOETHYL PHOSPHORAMIDITE BZ-DMT-DEOXYADENOSINE 2-CLPH DIESTER TRIETHYLAMMONIUM SALT

6-BENZOYLAMINOPURINE

6-BENZAMIDOPURINE

N6-BENZOYLAMINOPURINE

N6-BENZOYLADENINE

N-BZ-ADE

N-BENZOYLADENINE

N-BENZOYLAMINOPURINE

N-Benzolaminopurine

N-Benzoylaminopurine,99%

N-(5H-Purin-6-yl)benzamide

Benzamide, N-1H-purin-6-yl-

6-Benzoylaminopurin

N(sup 6)benzoyladenine

N-(1-purinyl)benzamide

N4-Benzoyl adenine

N6-Benzoyladenine, 98.0%(LC&T

N-(7H-purin-6-yl)benzamide

N6-Benzoyladenine&gt

N-(9H-Purin-6-yL

Benzamide, N-9H-purin-6-yl-

6-benzoyl hydrazine

N-Benzoylaminopurine USP/EP/BP

N4-Bz-adenine

N<sup>6</sup>-Benzoyladenine

4005-49-6

C12H9N5O

BioChemical

Biochemicals and Reagents

Nucleosides, Nucleotides, Oligonucleotides

Nucleoside Analogs

Purine

Biochemicals and Reagents

Nucleoside Analogs

Nucleosides, Nucleotides, Oligonucleotides

Biochemistry

Nucleobases and their analogs

Nucleosides, Nucleotides & Related Reagents